Antioxidant, hypolipidemic and hypoglycemic effect of red wine in wistar rats fed with obesogenic diet

Mucaca, Cornélio; Filho, José Henrique Tavares; Arruda, Luciana  Lima; Galvão, André Martins; Maia, Maria Bernardete de Sousa; Alves, Eryka Maria dos Santos; Franco, Eryvelton de Souza; Nascimento, Elizabeth do

doi:10.1016/j.fbio.2022.101671

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Over the last century, many studies have shown that there is an inverse relationship between antioxidant intake and various health problems, such as cancer, cardiovascular disease, and diabetes [ 50 , 51 , 52 , 53 ]. Antioxidants can be described as powerful shields against the negative effects of free radicals.…”

Section: Resultsmentioning

confidence: 99%

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

et al. 2022

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Spathodea campanulata is an important medicinal plant with traditional uses in the tropical zone. In the current work, we aimed to determine the chemical profiles and biological effects of extracts (methanolic and infusion (water)) from the leaves and stem bark of S. campanulata. The chemical components of the tested extracts were identified using LC-ESI-QTOF-MS. Biological effects were tested in terms of antioxidant (radical scavenging, reducing power, and metal chelating), enzyme inhibitory (cholinesterase, amylase, glucosidase, and tyrosinase), antineoplastic, and antiviral activities. Fifty-seven components were identified in the tested extracts, including iridoids, flavonoids, and phenolic acids as the main constituents. In general, the leaves-MeOH extract was the most active in the antioxidant assays (DPPH, ABTS, CUPRAC, FRAP, metal chelating, and phosphomolybdenum). Antineoplastic effects were tested in normal (VERO cell line) and cancer cell lines (FaDu, HeLa, and RKO). The leaf infusion, as well as the extracts obtained from stem bark, showed antineoplastic activity (CC50 119.03–222.07 µg/mL). Antiviral effects were tested against HHV-1 and CVB3, and the leaf methanolic extract (500 µg/mL) exerted antiviral activity towards HHV-1, inhibiting the viral-induced cytopathic effect and reducing the viral infectious titre by 5.11 log and viral load by 1.45 log. In addition, molecular docking was performed to understand the interactions between selected chemical components and viral targets (HSV-1 DNA polymerase, HSV-1 protease, and HSV-1 thymidine kinase). The results presented suggest that S. campanulata may be a bright spot in moving from natural sources to industrial applications, including novel drugs, cosmeceuticals, and nutraceuticals.

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Section: Resultsmentioning

confidence: 99%

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

et al. 2022

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“…Wine, rich in bioactive polyphenols, has been extensively studied for its positive effects on regulating obesity when consumed moderately ( Auger et al, 2002 , Chiva-Blanch et al, 2013 , Lucarini et al, 2021 ). Previous studies administered 3 mL/kg of red wine to rats on a high-fat diet (HFD), resulting in a 37.89 % reduction in triglyceride (TG) and a 26.4 % reduction in total cholesterol (TC) levels after 6 weeks, confirming its efficacy in lowering lipid levels ( Mucaca et al, 2022 ). The intricate connection between lipid metabolism and redox homeostasis is notable.…”

Section: Introductionmentioning

confidence: 88%

Sulfur dioxide-free wine with polyphenols promotes lipid metabolism via the Nrf2 pathway and gut microbiota modulation

Ma,

Yu,

Wang

et al. 2024

Food Chemistry: X

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A mosaic-structured framework applied in the healthy food design: insights from integrated in silico and in vitro approaches

Azevedo

Granato

Gonçalves

2023

Current Opinion in Food Science

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Antioxidant, hypolipidemic and hypoglycemic effect of red wine in wistar rats fed with obesogenic diet

Cited by 6 publications

References 19 publications

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

Sulfur dioxide-free wine with polyphenols promotes lipid metabolism via the Nrf2 pathway and gut microbiota modulation

A mosaic-structured framework applied in the healthy food design: insights from integrated in silico and in vitro approaches

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