Antioxidant identification using a colorimetric sensor array based on Co-N-C nanozyme

Liu, Bin; Xue, Yuting; Gao, Zeyu; Tang, Keru; Guo, Weinong; Chen, Zhengbo; Zuo, Xia

doi:10.1016/j.colsurfb.2021.112060

Cited by 27 publications

(20 citation statements)

References 26 publications

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“…Finally, in terms of application, a sensitive detection method for H 2 O 2 , glucose, and AA was developed with the optimized Cu-NC-700 SAzymes. Hongye FeÀ SSN [14] Fe [15] RuÀ AlaÀ C 3 N 4 [16] AÀ CoÀ NG [17] FeÀ NÀ C [18] Apt/FeÀ NÀ C [19] FeÀ NÀ C [20] Pt/NiCo-LDH [21] FeÀ NÀ C [22] CoÀ MoS 2 [23] FeÀ N/C [24] CoÀ NÀ C [25] Biomedical therapy Cancer…”

Section: Wet Chemical Synthesismentioning

confidence: 99%

Section: Biosensing Detectionmentioning

confidence: 99%

“…This colorimetric sensing array can be applied to detect the content of these five antioxidants in serum or even in binary and ternary mixtures, which has greatly advanced the level of detection (Figure 3). Liu Bin et al [25] even expanded the number of antioxidant species detectable by colorimetric sensing arrays to seven, including GSH, ascorbic acid (AA), cysteine (Cys), tannin (TA), catechin (C), dopamine (DA), buffer and even uric acid (UA) in serum samples. The used cobalt-based SAzymes CoÀ NÀ C catalyzed the oxidation of TMB by hydrogen peroxide at pH 3.8 and 4.6, respectively, and accomplished the sensing of antioxidants by different degrees of color development of different substrates, which has a promising future in medical diagnosis.…”

Section: Array Sensing Detection Of Antioxidantsmentioning

confidence: 99%

“…Fe−SSN [14] Fe [15] Ru−Ala−C 3 N 4 [16] A−Co−NG [17] Fe−N−C [18] Apt/Fe−N−C [19] Fe−N−C [20] Pt/NiCo‐LDH [21] Fe−N−C [22] Co−MoS 2 [23] Fe−N/C [24] Co−N−C [25] …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Single‐Atom Nanozymes for Biomedical Applications: Recent Advances and Challenges

Tang

Cai

et al. 2022

Chemistry An Asian Journal

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Nanozymes have received extensive attention in the fields of sensing and detection, medical therapy, industry, and agriculture thanks to the combination of the catalytic properties of natural enzymes and the physicochemical properties of nanomaterials, coupled with superior stability and ease of preparation. Despite the promise of nanozymes, conventional nanozymes are constrained by their oversized size and low catalytic capacity in sophisticated practical application environments. single-atom nanozymes (SAzymes) were characterized as nanozymes with high catalytic efficiency by uniformly distributed single atoms as catalysis sites, thus effectively addressing the defects of conventional nanozymes. This paper reviews the activity improvement scheme and catalytic mechanism of SAzymes and highlights the latest research progress of SAzymes in the fields of biomedical sensing and therapy. Eventually, the challenges and future directions of SAzymes are discussed in this paper.

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Section: Wet Chemical Synthesismentioning

confidence: 99%

Section: Biosensing Detectionmentioning

confidence: 99%

Section: Array Sensing Detection Of Antioxidantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Single‐Atom Nanozymes for Biomedical Applications: Recent Advances and Challenges

Tang

Cai

et al. 2022

Chemistry An Asian Journal

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“…Currently, most glucose detection methods with low LOD can only realize standard samples analysis, while our work greatly achieved glucose detection from 31 serum samples. Besides, compared to most of the complicated nanoenzymes ( Dong et al, 2016 ; Guo and Li, 2019 ; Zhang X. et al, 2021 ; Liu et al, 2021 ), an obvious advantage of Cu 2 O NPs as peroxidase mimic is their simple preparation and lower cost. Therefore, the prepared Cu 2 O NPs should be easily popularized and used in glucose detection.…”

Section: Introductionmentioning

confidence: 99%

A Copper-Based Biosensor for Dual-Mode Glucose Detection

Liu

et al. 2022

Front. Chem.

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Glucose is a source of energy for daily activities of the human body and is regarded as a clinical biomarker, due to the abnormal glucose level in the blood leading to many endocrine metabolic diseases. Thus, it is indispensable to develop simple, accurate, and sensitive methods for glucose detection. However, the current methods mainly depend on natural enzymes, which are unstable, hard to prepare, and expensive, limiting the extensive applications in clinics. Herein, we propose a dual-mode Cu2O nanoparticles (NPs) based biosensor for glucose analysis based on colorimetric assay and laser desorption/ionization mass spectrometry (LDI MS). Cu2O NPs exhibited excellent peroxidase-like activity and served as a matrix for LDI MS analysis, achieving visual and accurate quantitative analysis of glucose in serum. Our proposed method possesses promising application values in clinical disease diagnostics and monitoring.

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Portable Colorimetric Sensor Array Based on a Porous Single‐Atom Fe Nanozyme with Different Surface Sites for Identifying Artificially Ripened Fruits

Wu,

Lin,

Wang

et al. 2024

Adv Funct Materials

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Single‐atom nanozyme materials have demonstrated exceptional specific catalytic activity due to the atomic‐level dispersion of their active centers. However, the exploration of catalytic mechanisms for single‐atom catalysts is so far limited to the 2D surfaces of nanozymes. In this study, porous single‐atom Fe nanozyme (psaFeN) is successfully prepared through a straightforward coordination‐assisted polymerization‐assembly strategy. The psaFeN composite nanospheres are uniformly sized, exhibiting excellent dispersibility with well‐organized pore channels extending from the center to the surface. Density functional theory calculations reveal that in the psaFeN nanozyme, the (010) facets serve as the primary active surface, where Fe atoms form tri‐coordinated or tetra‐coordinated structures with doped nitrogen atoms. The (100) facets act as auxiliary reactive surfaces with tetra‐coordinated Fe─N as the active center. psaFeN exhibits excellent POD‐like activity (Km = 1.77 mM; Vmax = 173.53 × 10−⁸ M s−1). Given this exceptional bioactivity, a portable colorimetric biosensor is constructed for distinguishing artificially ripened fruits from naturally ripened ones. The sensor achieves precise discrimination with a detection limit as low as 310 nmol L−1. This study is anticipated to offer valuable insights into understanding the 3D catalytic mechanisms of single‐atom nanozymes, promoting their application in the development of robust biosensors for food safety.

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Antioxidant identification using a colorimetric sensor array based on Co-N-C nanozyme

Cited by 27 publications

References 26 publications

Single‐Atom Nanozymes for Biomedical Applications: Recent Advances and Challenges

Single‐Atom Nanozymes for Biomedical Applications: Recent Advances and Challenges

A Copper-Based Biosensor for Dual-Mode Glucose Detection

Portable Colorimetric Sensor Array Based on a Porous Single‐Atom Fe Nanozyme with Different Surface Sites for Identifying Artificially Ripened Fruits

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