Antioxidant intake in relation to serum C-reactive protein in mid-life and older African Americans

Rancaño, Katherine M; Ralston, Penny A.; Lemacks, Jennifer; Young-Clark, Iris; Ilich, Jasminka Z.

doi:10.1080/13557858.2018.1492707

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…Among inflammatory biomarkers evaluated in a cohort of elderly individuals supplemented with a combination of Se and coenzyme Q 10 in the Swedish KiSel project [12], the markers CRP, P-selectin [45] and osteoprotegerin (OPG) [46] were reduced or normalized following a four-year period of supplementation. In another cohort encompassing elderly women, Se supplementation was observed to ameliorate obesity-induced inflammatory responses [47]. Insulin-like growth factor 1 (IGF-1), considered to be a central biomarker in nutrition and inflammation [48], did increase following selenium supplementation [49].…”

Section: Ageing and Inflammationmentioning

confidence: 99%

Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review

et al. 2021

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Selenium (Se) is an essential dietary trace element that plays an important role in the prevention of inflammation, cardiovascular diseases, infections, and cancer. Selenoproteins contain selenocysteine in the active center and include, i.e., the enzymes thioredoxin reductases (TXNRD1–3), glutathione peroxidases (GPX1–4 and GPX6) and methionine sulfoxide reductase, involved in immune functions, metabolic homeostasis, and antioxidant defense. Ageing is an inevitable process, which, i.e., involves an imbalance between antioxidative defense and reactive oxygen species (ROS), changes in protein and mitochondrial renewal, telomere attrition, cellular senescence, epigenetic alterations, and stem cell exhaustion. These conditions are associated with mild to moderate inflammation, which always accompanies the process of ageing and age-related diseases. In older individuals, Se, by being a component in protective enzymes, operates by decreasing ROS-mediated inflammation, removing misfolded proteins, decreasing DNA damage, and promoting telomere length. Se-dependent GPX1–4 and TXNRD1–3 directly suppress oxidative stress. Selenoprotein H in the cell nucleus protects DNA, and selenoproteins residing in the endoplasmic reticulum (ER) assist in the removal of misfolded proteins and protection against ER stress. In this review, we highlight the role of adequate Se status for human ageing and prevention of age-related diseases, and further its proposed role in preservation of telomere length in middle-aged and elderly individuals.

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Section: Ageing and Inflammationmentioning

confidence: 99%

Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review

et al. 2021

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“…et al reported that in a cohort encompassing elderly women, selenium supplementation was observed to ameliorate obesity-induced inflammatory responses. There was an increase in insulin-like growth factor 1, a central biomarker in inflammation, 10 following selenium supplementation. 10 , 11 There are, however, limited studies that compare the selenium status, levels of inflammatory markers and oxidative stress between patients with ICM and healthy controls.…”

Section: Introductionmentioning

confidence: 99%

“…There was an increase in insulin-like growth factor 1, a central biomarker in inflammation, 10 following selenium supplementation. 10 , 11 There are, however, limited studies that compare the selenium status, levels of inflammatory markers and oxidative stress between patients with ICM and healthy controls. The impact of selenium on inflammation in the population with ICM requires further study.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Plasma Selenium, Antioxidant Status, Inflammatory Responses and Ischemic Cardiomyopathy: A Case-Control Study Based on Matched Propensity Scores

Luo¹,

He²,

Hu³

et al. 2022

JIR

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Background Ischemic cardiomyopathy (ICM) with high morbidity and mortality is closely associated with an abnormal equilibrium of circulation selenium levels. The oxidative stress theory is the most accepted theory of selenium causing ischemic cardiomyopathy. However, the role of inflammatory responses in ICM has received limited attention. Methods This study included 119 subjects, 43 of whom were patients with ICM, and 76 were healthy controls. Blood specimens were collected from subjects and serum levels of inflammatory and oxidative stress indicators and plasma levels of selenium were measured. Results When plasma selenium and indicators of inflammation and oxidative stress were compared between groups, plasma selenium levels were significantly lower in the ICM group than in the control group (68.83874 vs 104.39775, p =0.02032), while indicators of inflammation such as tumour necrosis factor-alpha (TNF-α) (79.09773 vs 46.15634, p <0.001), interleukin-6 (IL-6) (49.41484 vs 38.46923, p <0.01) and neutrophil/lymphocyte ratio (3.696574 vs 2.383658, p <0.001) were significantly higher in the ICM group than in the control group (all of these results were statistically different). Additionally, malondialdehyde (MDA), a marker of oxidative stress, was considerably higher in the ICM group than in the control group (61.63078 vs 39.0609, p <0.01). In contrast, there were no significant differences in superoxide dismutase (SOD) levels between groups ( p >0.05). The Poisson regression analysis revealed a significant association between selenium and high levels of MDA, IL-6 and TNF-α ( p <0.05). Additionally, selenium was negatively connected with SOD levels and the neutrophil/lymphocyte ratio, but this relationship was not statistically significant ( p =0.96, 0.15, respectively). Conclusion Selenium deficiency is strongly associated with the development of ICM, and with levels of inflammation and oxidative stress in patients with ICM. Selenium can prevent the development and delay the progression of ICM by alleviating inflammatory responses.

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Selenium, aging and aging-related diseases

2018

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Antioxidant intake in relation to serum C-reactive protein in mid-life and older African Americans

Abstract: Our study does not support the inverse relationship between antioxidants intake and CRP, but does support the evidence for obesity-induced inflammation and suggests the association can be applied to AA women.

Cited by 3 publications

References 47 publications

Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review

Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review

The Relationship Between Plasma Selenium, Antioxidant Status, Inflammatory Responses and Ischemic Cardiomyopathy: A Case-Control Study Based on Matched Propensity Scores

Selenium, aging and aging-related diseases

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