Antioxidant phytochemicals and gingerol content in diploid and tetraploid clones of ginger (Zingiber officinale Roscoe)

Sanwal, Satish Kumar; Rai, N.; Singh, Jagdish; Buragohain, Juri

doi:10.1016/j.scienta.2010.01.003

Cited by 53 publications

(33 citation statements)

References 25 publications

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“…Recently, Sanwal et al (2010) carried out a study to explore the variability between 18 diploid and tetraploid genotypes of Indian fresh ginger, including commercial cultivars and experimental genotypes for their gingerol content and antioxidant activity. The tetraploid ginger type was derived from the respective diploid ginger by shoot tip culture.…”

Section: Antioxidative Effects Of Gingermentioning

confidence: 99%

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

Kubra

Rao

2012

Critical Reviews in Food Science and Nutrition

165

118

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Ginger rhizome (Zingiber officinale Roscoe) is widely cultivated as a spice for its aromatic and pungent components. The essential oil and oleoresins from ginger are valuable products responsible for the characteristic flavor and pungency. Both are used in several food products such as soft beverages and also in many types of pharmaceutical formulations. More than 100 compounds have been reported from ginger, some of which are isolated and characterized, others are tentatively identified by GC-MS and / or LC-MS. [6]-Gingerol, the major gingerol in ginger rhizomes, has been found to possess many interesting pharmacological and physiological activities, such as anti-inflammatory, analgesic, and cardiotonic effects. Ginger is considered as "generally recognized as safe" (GRAS) by Food and Drug Administration (FDA), USA. Due to all these properties, ginger has gained considerable attention in developed countries in recent years, especially for its use in the treatment of inflammatory conditions. The present review is a persuasive presentation of the current information on processing, chemistry, biological activities, and medicinal uses of ginger. Further studies are required for the validation of the beneficial uses. Formulation for novel products and new usages may emerge in the years to come, based on the revealed results of various studies.

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Section: Antioxidative Effects Of Gingermentioning

confidence: 99%

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

Kubra

Rao

2012

Critical Reviews in Food Science and Nutrition

165

118

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“…The pungent principles of ginger rhizomes, the phenolic compounds zingerone, gingerols and shogaols, are the main factors determining the antioxidant activity of the rhizome [3,4]. The specific combination of these compounds determines its different biological activity, in particular the antioxidant capacity [5].…”

mentioning

confidence: 99%

Composition and Comprehensive Antioxidant Activity of Ginger (Zingiber officinale) Essential Oil from Ecuador

Höferl

Стоилова

Wanner³

et al. 2015

Natural Product Communications

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In the present study, the chemical composition and antioxidant potential of an essential oil of ginger rhizomes from Ecuador was elucidated. The analysis of the essential oil by GC/FID/MS resulted in identification of 71 compounds, of which the main are citral (geranial 10.5% and neral 9.1%), α-zingiberene (17.4%), camphene (7.8%), α-farnesene (6.8%) and β-sesquiphellandrene (6.7%). The in vitro antioxidant activity of the essential oil expressed by IC 50 in descending order is: hydroxyl radical (OH •) scavenging (0.0065 µg/mL) > chelating capacity (0.822 µg/mL) > 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid radical cation (ABTS •+) scavenging (3.94 µg/mL) > xanthine oxidase inhibition (138.0 µg/mL) > oxygen radical (О 2 •) scavenging (404.0 µg/mL) > 2,2diphenyl-1-picrylhydrazyl radical (DPPH •) scavenging (675 µg/mL). Lipid peroxidation inhibition of the essential oil was less efficient than butylhydroxytoluol (BHT) in both stages, i.e. hydroperoxide and malondialdehyde formation. In vivo studies in Saccharomyces cerevisiae demonstrated a significant dosedependent increase in antioxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), blocking the oxidation processes in yeast cells. Moreover, ginger essential oil in concentrations of 1.6 mg/mL increases the viability of cells to oxidative stress induced by H 2 O 2 .

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“…Ginger, the rhizome of Zingiber officinale (Zingiberaceae), has been widely used in foods, beverages, spices and dietary supplements. [6]‐Gingerol is the major pungent, nonvolatile, phenolic component of ginger (Jolad et al ., ; Sanwal et al ., ). [6]‐Gingerol has been shown to exhibit various biological activities, including antioxidant and anti‐inflammatory (Lantz et al ., ; Dugasani et al ., ), anxiolytic and mood modulating (Nievergelt et al ., ), anti‐tumorigenic and cancer‐preventive activities (Shukla and Singh ; Lee et al ., ).…”

Section: Introductionmentioning

confidence: 99%

“…[6]-Gingerol is the major pungent, nonvolatile, phenolic component of ginger (Jolad et al, 2004;Sanwal et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Determination and pharmacokinetics of [6]‐gingerol in mouse plasma by liquid chromatography–tandem mass spectrometry

Kim

Shin

Choi

et al. 2011

Biomedical Chromatography

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This study describes the development of a rapid and sensitive high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (LC-MS/MS) assay for the quantification of [6]-gingerol in mouse plasma and application to a pharmacokinetic study after dose ranging in mice. The assay involved a protein precipitation step with acetonitrile and an isocratic elution using a mobile phase consisting of acetonitrile and water containing 0.1% formic acid (80:20 v/v). The multiple reaction monitoring was based on the transition of m/z = 277.2 → 177.1 for [6]-gingerol and 294.2 → 137.1 for nonivamide (internal standard). The assay was validated to demonstrate the specificity, linearity, recovery, accuracy, precision and stability. The calibration curves were linear over the wide concentration range of 10-10,000 ng/mL (r ≥ 0.9988). The lower limit of quantification was 10 ng/mL using a small volume of mouse plasma (20 μL). The method was successfully applied to a pharmacokinetic study in mice after intravenous injection of [6]-gingerol at 1.5, 3 and 6 mg/kg doses. The pharmacokinetics of [6]-gingerol were linear over the dose range studied as demonstrated by the linear increase in area under the concentration-time curve (AUC(inf)) with no significant change in the systemic clearance (Cl(s)), volume of distribution (V(ss)) and elimination half-life (t(1/2)) as a function of dose.

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Antioxidant phytochemicals and gingerol content in diploid and tetraploid clones of ginger (Zingiber officinale Roscoe)

Cited by 53 publications

References 25 publications

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

Composition and Comprehensive Antioxidant Activity of Ginger (Zingiber officinale) Essential Oil from Ecuador

Determination and pharmacokinetics of [6]‐gingerol in mouse plasma by liquid chromatography–tandem mass spectrometry

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