Antioxidant potential and hypolipidemic effects of combined purple sweet potato (Ipomoea batatas L.) tuber extract with honey in rats given high cholesterol feed

Sutirtayasa, I Wayan Putu; Jawi, I Made

doi:10.15562/bmj.v6i3.716

Cited by 5 publications

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“…Purple sweet potato can disrupt the formation of cholesterol and LDL in hypercholesterolemic rat blood. 21,22 Purple sweet potato contains anthocyanin, ascorbic acid, and betaglucan that increase high density lipoprotein (HDL) concentrations to suppress LDL formation. This effect may partially be mediated through the inhibition of cholesterol ester transfer protein (CETP).…”

Section: Discussionmentioning

confidence: 99%

The Potential Effect Of Sweet Potato (Ipomoea Batatas L.) Extract On Total Cholesterol And Low-Density Lipoprotein (LDL) In Hypercholesterol-Model Wistar Rat (Rattus Norvegicus)

Setiawan

Abdi

Zatalini

et al. 2022

BHSJ

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Introduction: CHD has high development among 86% in the world with the prevalence in urban (0.6%) than rural (0.4 %) areas. Atherosclerosis is an inflammatory response in blood vessels due to hypercholesterolemia and oxidized LDL. LDL and total cholesterol levels can be reduced by anthocyanins compounds, which are contained in purple sweet potato (Ipomoea batatas L.) This study aimed to determine the effectiveness of purple sweet potato extract in reducing total cholesterol and LDL. Methods: This study was a post-test-only control group experimental design. Twenty-five Wistar rats were divided into five groups: normal control, negative control, and three treatment groups fed by purple sweet potato extract doses of 66.67, 133.33, and 266.67 mg/kg BW/day. Results: Based on the statistical analysis there were significant differences between the treatment group and control groups. The highest dose of purple sweet potato extract (266.67 mg/kg BW/day) has an optimal effect in decreasing total cholesterol and LDL levels. Conclusion: Purple sweet potato extract (266.67 mg/kg BW/day) can reduce total cholesterol and LDL levels of Wistar Rats.

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Section: Discussionmentioning

confidence: 99%

The Potential Effect Of Sweet Potato (Ipomoea Batatas L.) Extract On Total Cholesterol And Low-Density Lipoprotein (LDL) In Hypercholesterol-Model Wistar Rat (Rattus Norvegicus)

Setiawan

Abdi

Zatalini

et al. 2022

BHSJ

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“…In this study, the rats have received a dose of 0.2-0.4 cc which had been proven to resolve oxidative stress in the preeclampsia animal model according to Sugiritama et al (2016) [16]. In addition, many animal studies had confirmed the antioxidant activity of IB due to its secondary metabolite anthocyanin, as well as its safety at appropriate doses [7], [8], [9], [19].…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence shows that Ipomoea batatas (IB) L (purple sweet potato) is a promising plant of pharmacological importance. Some studies had proven that IB L extract could reduce blood cholesterol levels and might function as an antioxidant in rats and rabbits that were received high cholesterol diet [7], [8]. A study conducted on hypertensive patients found that IB L extract reduces blood pressure and oxidative stress [9].…”

Section: Introductionmentioning

confidence: 99%

“…Its expression in blood vessel endothelium was increasing after administration of IB L [11]. Anthocyanin is the main component of various flavonoids in IB L extract that had been proved to have strong antioxidant properties [7], [8], [9], [11]. A previous study developed tablet preparation since the tablet was relatively more stable, low price for packaging, easily swallowed and can be packed properly.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Hypolipidemic Effects of Ipomoea batatas L and Pandanus conoideus Lam Combination on Rats Fed with High Cholesterol Diet

Subawa¹,

Yasa²,

Jawi³

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Chronic hypercholesterolemia is an important predisposing factor of cardiovascular diseases. The underlying process is commonly associated with oxidative stress. AIM: This study aimed to evaluate the effects of Ipomoea batatas (IB) L tablet and Pandanus conoideus (PC) Lam extract against oxidative stress and lipid profile in rats. METHODS: This study used a pre- and post-test control group design. Wistar male rats were randomized into four groups consisting of seven rats each. The groups were control group, PC Lam extract 0.4 cc/rat/day (PC group), IB L tablet 200 mg/rat/day (IB group), and PC 0.2 cc+IB 200 mg/rat/day (PC+IB group). All groups were received high cholesterol diet for 4 weeks. The blood samples at baseline and the end of this study were used for the lipid profile, superoxide dismutase (SOD), and malondialdehyde (MDA) examination. The result was then analyzed with an Analysis of Variance test. RESULTS: There were significant differences in changes of total cholesterol, Low-density lipoprotein, triglycerides, high-density lipoprotein, MDA, and SOD in the treatment group (PC, IB, PC+IB) compared to the control (p < 0.001). The decrease of MDA and increase of SOD were mainly found in the PC+IB group compared to the PC group and IB group (p < 0.05). The changes in lipid profiles were mainly found in the PC+IB group and PC group compared to the IB group (p < 0.05). CONCLUSION: Administration of PC and IB combination is an effective hypolipidemic agent. This combination has superior antioxidant activity compared to the single-agent (PC or IB) and control.

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“…In rats fed a high-cholesterol diet, a combination of purple sweet potato tuber water extract and honey can keep lipid profiles and MDA in the normal range. 22 Medicinal plants can induce kidney injury by causing mild interstitial inflammation with vascular congestion, moderate inflammation, vascular congestion, and severe inflammation and vascular congestion. 23 Deoxycorticosterone acetate (DOCA-salt) was combined with purple sweet potato extract ethanol (EP) to repair kidney injury, decrease smooth muscle cell proliferation, and reduce aorta wall thickening.…”

Section: Histopathological Changes Involve Complex Interactions Betwe...mentioning

confidence: 99%

Histopathology of Nephrotoxicity Associated with Administered Water Extract Purple Sweet Potato (<i>Ipomoea batatas</i>) in Mice (<i>Mus musculus</i>) in Stratified Phases of Dose

Damayanti

Indriyanti

Kharisma

et al. 2022

Glob Med Health Commun

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The main aim of the registered purple sweet potato (Ipomoea batatas) is to provide minimize the adverse chemical drugs, in addition to its anti-inflammatory, antioxidant, and antimicrobial effects. Potentially adverse effects may be observed in laboratory animals in particular, the extent to which this administration can cause toxicity. This study aimed to examine the histopathology of nephrotoxicity associated with administered water extracts of purple sweet potato in mice with stratified doses. The study was conducted at the Biomedical Laboratory, Faculty of Medicine, Universitas Islam Bandung on September 2019. Female mice (Mus musculus) strain Swiss Webster, aged between 6–8 weeks weighing 25 to 30 g, were obtained from Biopharma Laboratory, Bandung. The animal was acclimatized for seven days before being administered water extract purple sweet potato: eleven mice, one control group, and ten treatment groups underwent toxicity doses of purple sweet potato water extract administration. Purple sweet potato variant of Ayamurasaki prepared in various oral doses. The results show in the control group there were no histopathological changes, but in the group administered water extract purple sweet potato from the first phase seems in a mild grade of macrophage accumulation, mild vacuolization of tubular epithelial cells, mild vascular dilatation, and mild hydrophilic degeneration. In the second phase, macrophage accumulation was visible in moderate grades. The LD50 of purple sweet potato extract is greater than 5,000 mg/kgBW. The findings of this study indicate that registration of purple sweet potato extract in confirmatory doses is safe to administer and did not exhibit any mortality. The toxicity test of purple sweet potato water extracts in the kidney exhibits minimal chemical effects.

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Antioxidant potential and hypolipidemic effects of combined purple sweet potato (Ipomoea batatas L.) tuber extract with honey in rats given high cholesterol feed

Cited by 5 publications

References 0 publications

The Potential Effect Of Sweet Potato (Ipomoea Batatas L.) Extract On Total Cholesterol And Low-Density Lipoprotein (LDL) In Hypercholesterol-Model Wistar Rat (Rattus Norvegicus)

The Potential Effect Of Sweet Potato (Ipomoea Batatas L.) Extract On Total Cholesterol And Low-Density Lipoprotein (LDL) In Hypercholesterol-Model Wistar Rat (Rattus Norvegicus)

Antioxidant and Hypolipidemic Effects of Ipomoea batatas L and Pandanus conoideus Lam Combination on Rats Fed with High Cholesterol Diet

Histopathology of Nephrotoxicity Associated with Administered Water Extract Purple Sweet Potato (<i>Ipomoea batatas</i>) in Mice (<i>Mus musculus</i>) in Stratified Phases of Dose

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