Antioxidant Properties of Extracts from &lt;i&gt;Chroogomphis rutillus&lt;/i&gt;

Chemistry & Biodiversity

Lan

Lü

et al. 2019

Chroogomphus rutilus is a rare fungal species that grows under pine trees and is now widely used as a functional food and pharmaceutical product. However, the chemical constituents and biological activities of Chroogomphus rutilus have been relatively limited. The present study aimed at determining the total polyphenols and flavonoids contents, biological activities and main phenolic compounds of Chroogomphus rutilus from different geographical origins at the stipe and pileus. The results suggested that Chroogomphus rutilus polyphenol extracts revealed a higher antioxidant, anti-inflammatory, and cytotoxic activities, and there were significant differences between samples from different locations and regions. Correlation analysis showed that the contents of total polyphenols and flavonoids were significantly correlated with antioxidant and antiinflammatory activities. However, only the content of total flavonoids was significantly correlated with cytotoxicity, which means that the cytotoxicity of Chroogomphus rutilus polyphenol extracts may be regulated by flavonoids or other compounds. HPLC-DAD analysis revealed that the main phenolic compound was protocatechuic acid, followed by baicalin, p-hydroxyphenylacetic acid and p-hydroxybenzoic acid, but comparing with the pileus extracts, the stipe extracts can be considered as a higher concentration of phenolic compounds. Therefore, antioxidant, anti-inflammatory and cytotoxic activities of Chroogomphus rutilus polyphenol extracts could be due to the identified compounds. This study investigated a deep knowledge about the constituents and activities of Chroogomphus rutilus and provided the reference for its application in food and pharmaceutical.

Section: Resultssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Antioxidant, Anti‐inflammatory and Cytotoxic Activities of Polyphenols Extracted from Chroogomphus rutilus

Chemistry & Biodiversity

Lan

Lü

et al. 2019

“…The scavenging abilities of 100% ethanol extracts on DPPH radicals have been reported as 86.85-90.54% at 2-4 mg · mL −1 . 6 The antioxidant components may be more easily dissolved in 100% ethanol than in 95% ethanol.…”

Section: Discussionmentioning

confidence: 99%

“…rutilus was reported to have good antioxidant properties, to have nitrite scavenging effects, and to inhibit nitrosamine formation. 6,7 The aim of this study was to evaluate the antioxidant, hypoglycemic, hypolipidemic, and antitumor bioactivities of a 95% ethanol extract of Ch. rutilus (CRE) to evaluate its healthful properties.…”

Section: Introductionmentioning

confidence: 99%

A Primary Study of the Antioxidant, Hypoglycemic, Hypolipidemic, and Antitumor Activities of Ethanol Extract of Brown Slimecap Mushroom, Chroogomphus rutilus (Agaricomycetes)

Zhao

et al. 2017

Int J Med Mushrooms

In vivo and in vitro treatments were carried out to investigate the effects of a 95% ethanol extract of Chroogomphus rutilus (CRE) on antioxidant, hypoglycemic, hypolipidemic, and antitumor properties. CRE showed potent radical scavenging activity against DPPH in vitro. It could increase antioxidant enzymatic activities (superoxide dismutase and glutathione peroxidase) and could reduce malondialdehyde content in vivo in mice in which aging was induced by D-galactose. CRE had hypoglycemic activity and could significantly inhibit α-glucosidase activity in vitro and decrease blood glucose concentration in vivo. CRE could decrease the serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels and increase the high-density lipoprotein cholesterol level in diabetic mice. The MTT assay showed that CRE also had a certain inhibitory effect on the tumor cells. These results suggest that CRE may be beneficial for human health and could be useful for applications in medicine, the food industry, and agriculture.

“…This mushroom has become increasingly popular in China, due to its unique and subtle flavor, and probably the existence of some physiologically beneficial components. Although some studies were carried on the biological characteristic, biosorption of Cu (II) and antioxidant activities of this mushroom [4][5][6][7], little information is available about their nitrite scavenging (NS) and nitrosamine formation inhibiting (NFI) properties. Our objective was to evaluate NS and NFI properties of various extract from Chroogomphis rutillus in simulated gastric conditions.…”

Section: Introductionmentioning

confidence: 99%

Effect of <i>Chroogomphis Rutillus</i> Extracts on Activity of Nitrite Scavenging and Nitrosamine Formation Inhibition

Jin

et al. 2011

AMR

Chroogomphis rutillusextracts were prepared with solvent of petroleum ether, acetic ester, methanol and water. The effects of four different extract on nitrite scavenging (NS) and nitrosamine formation inhibiting (NFI) were evaluated in vitro systems. Results showed that all the extract showed NS and NFI potentials with a dose-dependent manner. With regard to NS activity, at 50μg/mL, the scavenging rates of ethyl acetate and methanol extracts were 96.65% and 93.48%, respectively. While, those of petroleum ether and water extract were only 86.96% and 26.09%, respectively. With regard to NFI activity,at 200μg/mL, both petroleum ether and ethyl acetate extracts showed excellent inhibition abilities of 94.46% and 91.33%, respectively, much higher than those of methanol and water extract (78.57% and 4.06%, respectively) (P<0.05).Chroogomphis rutillusespecially ethyl acetate extract may have a preventive effect against carcinogenesis induced by nitrosamines.