Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging

Kasapović, Jelena; Stojiljković, Vesna; Gavrilović, Ljubica; Popović, Nataša; Milićević, Živana

doi:10.1100/2012/982594

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…The proposition that the aged cells are more amenable to damage from ionizing radiation comes from the theory of blood cell antioxidant enzyme activities decreasing with age. [ 14 ] Ionizing radiation has shown to worsen the already unbalanced oxidant-antioxidant status in aging cells. Membrane damage response efficiency of cells is also shown to decline with age.…”

Section: Discussionmentioning

confidence: 99%

Irradiating stored blood and storing irradiated blood

Balasubramanyam

Basavarajegowda

Nandeesha

et al. 2021

Asian Journal of Transfusion Science

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INTRODUCTION: Gamma Irradiation of blood products accentuates biochemical changes in the blood stored at 4°C. This study tried to compare the changes in potassium, sodium, glucose, lactate, and lactate dehydrogenase (LDH) levels in packed red blood cell (PRBC) units irradiated at various time points and then stored versus those stored for a particular period then irradiated. METHODOLOGY: One hundred and eighty units of RBCs were randomly assigned equally to be irradiated or not. Eighteen units each were irradiated by gamma irradiator using cobalt 60 (BI 2000) on day 1, 7, 14, 21, and 28 of their storage, respectively, in the irradiation group. All the units were assessed for their plasma levels of potassium, sodium, glucose, LDH, and lactate by clinical chemistry auto analyzer Beckman coulter AU680 weekly. The values were documented and analyzed by SPSS. RESULTS: Baseline values on day 1 for studied biochemical parameters were comparable between irradiated and nonirradiated groups. Mean values of potassium, lactate and LDH were higher in irradiated than nonirradiated PRBC bags. In contrast, Sodium and Glucose mean values were lower than baseline values. Maximum cumulative mean values were noted in day-21 irradiated bags when the parameters were measured on day-28 for potassium and lactate levels. This was followed by day 14 irradiated bags, followed by day 7 irradiated bags. CONCLUSION: The study indicates that irradiation of red cells later in their storage period had comparatively more detrimental changes in relation to potassium and lactate than irradiation in earlier days. Consideration of irradiation to be performed as close to the issue as possible to reduce a lesser number of days of storage postirradiation is to be explored.

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Section: Discussionmentioning

confidence: 99%

Irradiating stored blood and storing irradiated blood

Balasubramanyam

Basavarajegowda

Nandeesha

et al. 2021

Asian Journal of Transfusion Science

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“…The irradiation of aging cells that already contain large amounts of active oxygen will undoubtedly overwhelm the antioxidant system responsible for removing excess amounts of oxygen metabolites [ 121 ]. The antioxidant protection against therapeutic and relieved doses of IR in human blood decreases with age [ 122 ]. These studies illustrate the role of oxidative stress regulation systems in determining the radiation sensitivity of senescent cells.…”

Section: Effect Of Radiation-induced Brain Agingmentioning

confidence: 99%

Ionizing Radiation-Induced Brain Cell Aging and the Potential Underlying Molecular Mechanisms

Wang

Yin

Huang

et al. 2021

Cells

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Population aging is occurring rapidly worldwide, challenging the global economy and healthcare services. Brain aging is a significant contributor to various age-related neurological and neuropsychological disorders, including Alzheimer’s disease and Parkinson’s disease. Several extrinsic factors, such as exposure to ionizing radiation, can accelerate senescence. Multiple human and animal studies have reported that exposure to ionizing radiation can have varied effects on organ aging and lead to the prolongation or shortening of life span depending on the radiation dose or dose rate. This paper reviews the effects of radiation on the aging of different types of brain cells, including neurons, microglia, astrocytes, and cerebral endothelial cells. Further, the relevant molecular mechanisms are discussed. Overall, this review highlights how radiation-induced senescence in different cell types may lead to brain aging, which could result in the development of various neurological and neuropsychological disorders. Therefore, treatment targeting radiation-induced oxidative stress and neuroinflammation may prevent radiation-induced brain aging and the neurological and neuropsychological disorders it may cause.

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Aging and radiation: bad companions

et al. 2015

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Aging involves a deterioration of cell functions and changes that may predispose the cell to undergo an oncogenic transformation. The carcinogenic risks following radiation exposure rise with age among adults. Increasing inflammatory response, loss of oxidant/antioxidant equilibrium, ongoing telomere attrition, decline in the DNA damage response efficiency, and deleterious nuclear organization are age-related cellular changes that trigger a serious threat to genomic integrity. In this review, we discuss the mechanistic interplay between all these factors, providing an integrated view of how they contribute to the observed age-related increase in radiation sensitivity. As life expectancy increases and so it does the medical intervention, it is important to highlight the benefits of radiation protection in the elderly. Thus, a deep understanding of the mechanistic processes confining the threat of aging-related radiosensitivity is currently of foremost relevance.

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Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging

Cited by 3 publications

References 36 publications

Irradiating stored blood and storing irradiated blood

Irradiating stored blood and storing irradiated blood

Ionizing Radiation-Induced Brain Cell Aging and the Potential Underlying Molecular Mechanisms

Aging and radiation: bad companions

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