Antioxidant response analysis in the brain after pilocarpine treatments

Tejada, Silvia; Roca, C.; Sureda, Antoni; Rial, Rubén V.; Gamundı́, Antoni; Esteban, Susana

doi:10.1016/j.brainresbull.2006.03.002

Cited by 50 publications

(32 citation statements)

References 48 publications

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“…Nascimento et al (2005) showed an increase in activity of catalase in striatum of young rats, 1 h after P400-induced seizures. Similarly, Tejada et al (2006) demonstrated an increase in the activity of catalase and other antioxidant enzymes involved in free radical scavenging in rat brain 2 h after pilocarpine treatment. Recently, Gibbs et al (2006) reported, in an electrical stimulation model of SE, a specific pattern of biochemical change after SE.…”

Section: Discussionmentioning

confidence: 91%

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Effects of Levetiracetam in Lipid Peroxidation Level, Nitrite–Nitrate Formation and Antioxidant Enzymatic Activity in Mice Brain After Pilocarpine-Induced Seizures

et al. 2007

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: Oxidative stress has been implicated in a large number of human degenerative diseases, including epilepsy. Levetiracetam (LEV) is a new antiepileptic agent with broad-spectrum effects on seizures and animal models of epilepsy. Recently, it was demonstrated that the mechanism of LEV differs from that of conventional antiepileptic drugs. Objectifying to investigate if LEV mechanism of action involves antioxidant properties, lipid peroxidation levels, nitrite-nitrate formation, catalase activity, and glutathione (GSH) content were measured in adult mice brain. The neurochemical analyses were carried out in hippocampus of animals pretreated with LEV (200 mg/kg, i.p.) 60 min before pilocarpine-induced seizures (400 mg/kg, s.c.). The administration of alone pilocarpine, 400 mg/kg, s.c. (P400) produced a significant increase of lipid peroxidation level in hippocampus. LEV pretreatment was able to counteract this increase, preserving the lipid peroxidation level in normal value. P400 administration also produced increase in the nitrite-nitrate formation and catalase activity in hippocampus, beyond a decrease in GSH levels. LEV administration before P400 prevented the P400-induced alteration in nitrite-nitrate levels and preserved normal values of catalase activity in hippocampus. Moreover, LEV administration prevented the P400-induced loss of GSH in this cerebral area. The present data suggest that the protective effects of LEV against pilocarpine-induced seizures can be mediated, at least in part, by reduction of lipid peroxidation and hippocampal oxidative stress.

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Section: Discussionmentioning

confidence: 91%

“…Tejada et al (2006) showed induced lipid peroxidation by pilocarpine in cortex and hippocampus of rats. In accordance with Freitas et al (2004b), lipid peroxidation levels and nitrite content are increased during the acute period of P400-induced seizures in adult rats' hippocampus, striatum, and frontal cortex.…”

Section: Discussionmentioning

confidence: 98%

Effects of Levetiracetam in Lipid Peroxidation Level, Nitrite–Nitrate Formation and Antioxidant Enzymatic Activity in Mice Brain After Pilocarpine-Induced Seizures

et al. 2007

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“…The glutamate receptors are activated subsequently so acidification occurs in neurons because of Ca 2+ entry and this can be associated with the death of central neurons (Reynolds & Hastings, 1995;Bellisimo, et al, 2001). This countenance can be altered by increased ROS production or decreased intracellular antioxidant defense systems (Tejada, et al, 2006 (Hennekens, et al, 1996).…”

Section: The Redox Status Of the Brainmentioning

confidence: 99%

The Stance of Antioxidants in Brain Tumors

Atukeren¹,

Yiğitoğlu²

2013

Clinical Management and Evolving Novel Therapeutic Strategies for Patients With Brain Tumors

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“…The increased metabolites may interact with glutamatergic receptors to produce part of its stimulatory action on the central nervous system (Maczurek et al, 2008;Michiels et al, 1994). The reduction in nitrite content, after pretreatment with DMF from P. insignis, is most readily explained as a consequences of radical formation inhibiting, scavenges reactive oxygen species and lipid peroxidation products (Tejada et al, 2006). Herein, we clearly showed that DMF from P. insignis decreased the frequency of pilocarpine-induced seizures and increased the survival rate.…”

Section: Lipid Peroxidation Level and Nitrite Content In Striatum Of mentioning

confidence: 66%

Evaluation of effects of dichloromethane fraction from Platonia insignis on pilocarpine-induced seizures

Júnior¹,

Ferraz²,

Feitosa³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The objective of present study was to evaluate the antioxidant and anticonvulsant activities of dichloromethane fraction (DMF) from Platonia insignis Mart., Clusiaceae. The DMF from P. insignis (2 mg/kg) was tested by intraperitoneal (i.p.) to evaluate effects on lipid peroxidation level, nitrite formation, as well as on locomotor and anticonvulsant activities. Wistar rats were treated with, (saline/ Tween 80 0.5%, i.p., control group), DMF (2 mg/kg, i.p., DMF group), pilocarpine (400 mg/kg, i.p., P400 group), or the combination of DMF (2 mg/kg, i.p.) and pilocarpine (400 mg/kg, i.p., DMF plus P400). After the treatments all groups were observed for 24 h. In P400 group rats there was a decrease in the motor activity when compared with control group. In DMF plus P400 co-administered rats was observed an increase in motor activity when compared with P400 group. In P400 group rats there was a significant increase in lipid peroxidation and nitrite levels. In DMF plus P400 co-administered rats, antioxidant treatment significantly reduced the lipid peroxidation level and nitrite content after seizures. Previous findings strongly support the hypothesis that oxidative stress occurs in rat striatum during pilocarpine-induced seizures, and our results imply that strong neuprotective effect on this brain region could be achieved using DMF from P. insignis.

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Antioxidant response analysis in the brain after pilocarpine treatments

Cited by 50 publications

References 48 publications

Effects of Levetiracetam in Lipid Peroxidation Level, Nitrite–Nitrate Formation and Antioxidant Enzymatic Activity in Mice Brain After Pilocarpine-Induced Seizures

Effects of Levetiracetam in Lipid Peroxidation Level, Nitrite–Nitrate Formation and Antioxidant Enzymatic Activity in Mice Brain After Pilocarpine-Induced Seizures

The Stance of Antioxidants in Brain Tumors

Evaluation of effects of dichloromethane fraction from Platonia insignis on pilocarpine-induced seizures

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