Antioxidant status during the course of Eimeria tenella infection in broiler chickens

Georgieva, N.; Koinarski, V.; Gadjeva, V.

doi:10.1016/j.tvjl.2005.07.016

Cited by 115 publications

(78 citation statements)

References 22 publications

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“…Therefore, the increased activity of CAT perhaps was a compensation for oxidative damage. Similar phenomena have also been observed in the test of broiler chicks experimentally infected with Eimeria tenella (Georgieva et al 2006).…”

Section: Discussionsupporting

confidence: 83%

Effects of dietary conjugated linoleic acid on the duodenal mucosal immunity response and redox status of broiler chicks infected with Eimeria aceruvlina

Liu¹,

Liu²,

Yang³

et al. 2016

Czech J. Anim. Sci.

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ABSTRACT:The present experiment investigated the effects of conjugated linoleic acid (CLA) on the growth performance, oocyst shedding, duodenal mucosal immune response, and redox status of broiler chicks infected with Eimeria acervulina. Totally 144 birds were fed either the basal diet or 1.5% CLA diet for 21 days, and then half of them from each dietary treatment were inoculated with 10 000 Eimeria acervulina sporulated oocysts. Compared with the basal diet, the 1.5% CLA diet partially ameliorated the growth inhibition (P < 0.01) and decreased the oocyst shedding of broiler chicks at ca. 6-9 days post-inoculation (P < 0.01). Additionally the dietary CLA significantly increased the percentage of CD8 + T lymphocytes in the duodenal epithelium (P < 0.05), and showed no obvious effect on the interferon γ expression in duodenal mucosa (P > 0.05). The dietary CLA also notably suppressed the increase of malondialdehyde (P < 0.05) and the decrease of glutathione concentration (P < 0.01) in duodenal mucosa of the infected birds, without changing the activities of total superoxide dismutase and catalase (P > 0.05). These results demonstrate the protective effect of dietary CLA on the broiler chicks infected with Eimeria acervulina, and anticoccidial effects of dietary CLA are most likely related to the increased proportions of CD8 + T lymphocytes in duodenal epithelium and the inhibition on the decrease of duodenal mucosal glutathione after Eimeria acervulina infection.

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Section: Discussionsupporting

confidence: 83%

Effects of dietary conjugated linoleic acid on the duodenal mucosal immunity response and redox status of broiler chicks infected with Eimeria aceruvlina

Liu¹,

Liu²,

Yang³

et al. 2016

Czech J. Anim. Sci.

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“…deterioration in the food conversion rate and is doubtless also related to impaired endogenous enzymatic systemic defence (Chapman 1997, Georgieva et al 2006. Metwaly et al (2013) also attributed the reduction in rabbits' body weight during the course of intestinal coccidial infection to factors including depletion of growth hormones, distributed metabolic status and electrolyte homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Gene expression, oxidative stress and apoptotic changes in rabbit ileum experimentally infected with Eimeria intestinalis

Abdel-Haleem¹,

Aboelhadid²,

Sakran³

et al. 2017

FOLIA PARASIT

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Abstract:Coccidiosis is a parasitic disease caused by protists (apicomplexans) of the genus Eimeria Schneider, 1875 and is considered to be the most important disease faced by rabbit breeders due to its high morbidity. In the present study, the antioxidant status and changes in apoptosis and in the expression of some genes were quantified in rabbits' ilea following infection with Eimeria intestinalis Cheissin, 1948. Rabbits, orally infected with 1 × 10 5 sporulated oocysts of E. intestinalis, started to shed oocysts in their faeces on 8 days post infection (dpi) and reached maximum excretion on 10 dpi, with approximately 5 million oocysts. This was accompanied by a significant decrease in the live body weight of infected rabbits. Also, malondialdehyde and nitric oxide were significantly increased while catalase and glutathione were significantly decreased in the ileum tissues of the infected rabbits. In addition, a significant increase was observed in the percentages of apoptotic cells in the ilea of the infected rabbits. Furthermore, interleukin-1β and interleukin-2 mRNA levels were significantly down-regulated and mRNA levels of interleukin-6, interferon gamma and inducible nitric oxide synthase were significantly up-regulated, while those of C-reactive protein remained unchanged. We conclude that infection with E. intestinalis induces oxidative stress, a significant increase in the percentage of apoptotic cells and a diverse and robust Th1 and Th1-related cytokine response in the ileum tissues.

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“…Indeed, vitamins E, A, carnitine, selenium and some phytochemicals can affect SOD expression and concentration in various stress conditions. It is interesting that the same compounds can affect other vitagenes, namely thioredoxins, sirtuins and heat shock proteins [2,178]. Therefore, it would be of considerable interest to develop an antioxidant-based composition/ supplement for decreasing negative consequences of various stresses in poultry and pig production.…”

Section: Nutritional Modulation Of Vitagenesmentioning

confidence: 99%

“…mycotoxins in the feed, immunosuppression, high temperature, etc.). In such a case, additive supplementation via drinking system is a valuable option [178]. In fact, modern commercial poultry and pig houses have water medication equipment installed, which can be perfectly used for the aforementioned supplementations.…”

Section: Nutritional Modulation Of Vitagenesmentioning

confidence: 99%

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Surai¹

2016

J Anim Res Nutr

168

135

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Commercial poultry production is associated with various stresses responsible for decreasing productive and reproductive performance of growing chicks, breeders and commercial layers. A growing body of evidence shows that most of stresses in poultry production at the cellular level are associated with oxidative stress. Recently, a concept of the cellular antioxidant defense has been revised with special attention paid to cellular redox status maintenance and cell signaling. In fact, antioxidant systems of the living cell are based on three major levels of defense and superoxide dismutase (SOD) is shown to belong to the first level of the antioxidant defense network. Cellular antioxidant defenses are shown to include several options and vitagene activation in stress conditions is considered as a fundamental adaptive mechanism. The vitagene family includes various genes regulating synthesis of protective molecules including thioredoxins, sirtuins, heat shock proteins and SOD. However, by the time of writing no comprehensive review on the roles and effects of SOD in poultry biology has appeared. Therefore, the aim of this review is a critical analysis of the role of SOD in poultry biology with specific emphasis to its functions as an essential part of the vitagene network. From the analysis of the recent data related to SOD in poultry physiology and adaptation to stresses it is possible to conclude that: a) SOD as important vitagene is the main driving force in cell/body adaptation to various stress conditions. Indeed, in stress conditions additional synthesis of SOD is an adaptive mechanism to decrease ROS formation; b) If the stress is too high SOD activity is decreased and apoptosis is activated; c) there are tissue-specific differences in SOD expression which also depends on the strength of such stress-factors as heat, heavy metals, mycotoxins and other stressors; d) SOD is shown to provide an effective protection against lipid peroxidation in chicken embryonic tissues and semen; e) SOD is shown to be protective in heat and cold stress, toxicity stress as well as in other oxidative-stress related conditions in poultry production; f) there are complex interactions inside the antioxidant network of the cell/body to ensure an effective maintenance of homeostasis in stress conditions. Indeed, in many cases, nutritional antioxidants (vitamin E, selenium, carotenoids, phytochemicals, etc.) in the feed can increase SOD expression; g) nutritional means of SOD upregulation in stress conditions of poultry production and physiological and commercial consequences await further investigation; h) vitagene upregulation in stress conditions is emerging as an effective means for stress management.

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Antioxidant status during the course of Eimeria tenella infection in broiler chickens

Cited by 115 publications

References 22 publications

Effects of dietary conjugated linoleic acid on the duodenal mucosal immunity response and redox status of broiler chicks infected with Eimeria aceruvlina

Effects of dietary conjugated linoleic acid on the duodenal mucosal immunity response and redox status of broiler chicks infected with Eimeria aceruvlina

Gene expression, oxidative stress and apoptotic changes in rabbit ileum experimentally infected with Eimeria intestinalis

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

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