Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty

Abstract

Background Oxidative stress is a disruption of the pro-oxidative-antioxidant balance, caused by excessive production or ineffective removal of reactive oxygen species. Material/Methods The study included 42 male patients aged 38 to 69 years. The first group consisted of 21 men with osteoarthritis after primary hip arthroplasty using the Smith & Nephew Birmingham Hip Resurfacing implant. The second group included 21 men after hip arthroplasty using the femoral neck SPIRON K-implant. In both groups, concentrations of ions, the antioxidant system in the blood, and parameters of oxidative stress were evaluated twice. Clinical assessment using the Western Ontario and McMaster Universities Osteoarthritis Index, Harris Hip Score, and Short Form (12) Health Survey (SF-12) scales was performed. Results Concentrations of metal ions in the blood and the level of oxidative stress were significantly higher in the resurfacing group than in the femoral neck arthroplasty group. The response of the antioxidant system was significantly greater in the femoral neck arthroplasty group. During clinical evaluation, groups did not show significant differences, with the exception of greater shortening of the operated limb and a lower score in the mental-sphere of the SF-12 scale in the resurfacing arthroplasty group. Conclusions Resurfacing hip arthroplasty increased oxidative stress, increased the concentration of metal ions, and did not affect alignment of the abbreviation of the operated limb. A significant improvement in the quality of life of patients in the mental sphere according to the SF-12 occurred after the application of resurfacing arthroplasty, in the first month after the procedure.

Influence of Physical Activity and Cup Orientation on Metal Ion Release and Oxidative Stress in Metal-on-Metal and Ceramic-on-Metal Total Hip Arthroplasty

“…Our results agree with other studies showing the absence of a relationship between Cr and Co blood concentrations and several markers of oxidative stress in patients with M-M THA and resurfacing [48,[60][61][62]. Another study comparing M-M hip resurfacing with C-C THA showed increased oxidative stress markers in the resurfacing patients [59]. The discrepancies observed between the aforementioned studies could be related to methodological differences in evaluating oxidative stress.…”

“…In a patient undergoing hip replacement revision with elevated blood and urinary concentrations of Cr and Co, an association was reported between metallosis and increased expression of NADPH-Oxidase 4 (NOX4), a well-known compound responsible for ROS generation in muscle tissue [23]. Other studies have suggested a relationship between metallosis and oxidative stress [24,25,59]. According to these reports, our initial hypothesis was that the patients with M-M, with higher Cr and Co levels than the C-M group and the control group, should have greater systemic oxidative stress.…”

“…The discrepancies observed between the aforementioned studies could be related to methodological differences in evaluating oxidative stress. We evaluated oxidative stress by measuring MDA and TAC, as these markers are the most frequent indicators of lipid peroxidation and have been used in other studies [59,[63][64][65].…”

“…All patients in the C-M group had a head size of 36, with an average cup size of 54.3 (range: 50 to 58). Patients with the M-M pair had an average head size of 46.6 (range: 36 to 53) and an average cup size of 54.2 (range: [48][49][50][51][52][53][54][55][56][57][58][59][60]. The inclination of the cup in the coronal plane of the whole sample was 50.7 • , with an SD of 7.3 • .…”

An Assessment of Ankle Function, Oxidative Damage, and Inflammatory Factor Levels in Minimally Invasive Ankle Joint Fusion Surgery for the Treatment of Traumatic Ankle Osteoarthritis

“…Surgical trauma triggers imbalances in various factors within the patient's body. Trauma and pain induce oxidative stress and inflammatory responses in the body (Ochocki et al, 2022). Postoperative patients in orthopedics experience localized pain and restricted mobility, which can contribute to complications such as pneumonia, venous thrombosis, and pressure ulcers.…”