Antioxidants in dermatology

Pai, Varadraj V; Shukla, Pankaj; Kikkeri, Naveen Narayanshetty

doi:10.4103/2229-5178.131127

Cited by 31 publications

(31 citation statements)

References 11 publications

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“…According to the antioxidant activity of moringa seed oil, moringa seed oil cream may protect the skin by limiting the free-radical production, preventing oxidative stress, and enhancing DNA repair upon exposure to the air, UV radiation, pollutants, and chemicals that cause skin damage [34,35]. In addition, moringa seed oil cream may provide skin with hydration and increase the moisture retention to aid in revitalizing the skin.…”

Section: Discussionmentioning

confidence: 99%

Moringa oleifera Seed Oil Formulation Physical Stability and Chemical Constituents for Enhancing Skin Hydration and Antioxidant Activity

et al. 2020

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Moringa oleifera seed oil has been recognized for its benefits in relation to the skin. The objective of this study was to evaluate the chemical composition and antioxidant activity of moringa seed oil, to formulate a moringa seed oil cream, and to determine the efficacy of moringa seed oil cream in vivo. The chemical components of moringa seed oil were analyzed by high-performance liquid chromatography and gas chromatography. The antioxidant activity of the oil was determined by a 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging assay. An oil-in-water cream containing moringa seed oil was developed and characterized for antioxidant activity. The moringa seed oil cream was further subjected to the accelerated stability test of heating–cooling cycles for six cycles and stored isothermally at 4, 30, and 45 °C for 28 days. The efficacy of moringa seed oil cream was investigated in 32 participants by measuring their skin hydration, erythema, melanin values, and visco-elasticity. The results showed that moringa seed oil contained α-tocopherol, plant sterols, and fatty acids. The oil had antioxidant activity with a 50% of initial concentration (IC50) value of 121.9 mg/mL. The stability study indicated that the pH, viscosity, and rheological behavior of the cream containing moringa seed oil were not significantly changed after storage at 4, 30, and 45 °C for 28 days and six heating–cooling cycles. The moringa seed oil cream exhibited in vitro antioxidant activity and increased the in vivo skin hydration level compared with the cream base. There was no report of skin irritation from moringa seed oil cream application, suggesting that the moringa seed oil cream developed in this study was appropriate for pharmaceutical and cosmetic uses. A M. oleifera seed oil cream was successfully developed. The moringa seed oil cream possessed antioxidant activity, enhanced the skin hydration level, and reduced skin erythema, but did not affect the melanin content and skin visco-elasticity. The moringa seed oil cream did not induce skin irritation and, thus, was safe to use.

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Section: Discussionmentioning

confidence: 99%

Moringa oleifera Seed Oil Formulation Physical Stability and Chemical Constituents for Enhancing Skin Hydration and Antioxidant Activity

et al. 2020

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“…The skin has a vast antioxidant system, including enzymatic antioxidants, such as glutathione peroxidase (GPX), glutathione S-transferase, glutathione reductase, superoxide dismutase (SOD) and catalase, as well as non-enzymatic antioxidants, including ascorbic acid (vitamin C), glutathione (GSH), ubiquinol, uric acid, vitamin A, melanin, alpha-tocopherol (vitamin E), carotenoids (beta-carotene, lutein, zeaxanthin, and alpha-carotene) and sulfhydryls. 2,3 Flavonoids, coenzyme Q10, alpha-lipoic acid, selenium, pyruvate, and bilirubin are other examples of endogenous non-enzymatic antioxidants. We can also obtain antioxidants exogenously via food intake.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and antioxidant strategies in dermatology

2016

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Oxidative stress results from a prooxidant-antioxidant imbalance, leading to cellular damage. It is mediated by free radicals, such as reactive oxygen species or reactive nitrogen species, that are generated during physiological aerobic metabolism and pathological inflammatory processes. Skin serves as a protective organ that plays an important role in defending both external and internal toxic stimuli and maintaining homeostasis. It is becoming increasingly evident that oxidative stress is involved in numerous skin diseases and that antioxidative strategies can serve as effective and easy methods for improving these conditions. Herein, we review dysregulated antioxidant systems and antioxidative therapeutic strategies in dermatology.

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“…The rising cases of skin disorders have demanded development of natural antioxidants for skin. These antioxidants have capacity to increase the endogenous antioxidant potential of the skin and neutralizing ROS induced by other extraneous factors such as ultraviolet radiations and air pollutants ( Pai et al., 2014 ). Many natural agents like Vitamin A, Vitamin C, coenzyme Q 10,beta- carotene, silymarin, pycnogenol, procyanidins have been in use in antiaging therapies ( Singh, 2009 ).…”

Section: Safranal In Skin Photoagingmentioning

confidence: 99%

The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review

Nanda

Madan

2021

Heliyon

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Reactive oxygen species (ROS) are produced as a result of various environmental factors and cellular metabolism reactions creating oxidative stress. The reversible oxidative modification on proteins such as cysteine oxidation may be useful and can play positive role. ROS generated offer some benefits such as cellular signalling and tissue repair when present in low concentration. However, most of the times, these reactive species cause detrimental effects to cell components which leads to various pathological conditions which causes or aggravates diseases due to oxidative stress. The degenerative diseases due to oxidative stress are diabetes, cardiovascular diseases, epilepsy, cancer and aging. Antioxidants are the compounds which scavenge these free radicals and hence neutralize their effects. Research has enabled the use of natural antioxidants as therapeutic agent in the treatment of diseases. Safranal is one such natural agent which is a major volatile component of saffron. Saffron, Red gold is the most expensive spice found in limited region of the planet and is also reported to be used in traditional systems of medicine. Chemically, safranal is a monoterpene aldehyde possessing a sweet fragrance. While exploring for the photoprotective properties of safranal, we learnt about the immense antioxidant potential of safranal. Investigation by various research groups established safranal as an anti-inflammatory, antidepressant, anxiolytic, antiasthamatic, antihypertensive, anticonvulsant, anticancer and antitussive and antigenotoxic agent. It has brought researchers over the world to explore the antioxidant benefits of saffron for human health. In the present paper, potential of safranal and its related molecules as radical scavenger in combating oxidative stress, diseased conditions is collated and the underlying mechanisms have been explained. Various cell lines and animal models used for study of Safranal have been discussed.

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Antioxidants in dermatology

Cited by 31 publications

References 11 publications

Moringa oleifera Seed Oil Formulation Physical Stability and Chemical Constituents for Enhancing Skin Hydration and Antioxidant Activity

Moringa oleifera Seed Oil Formulation Physical Stability and Chemical Constituents for Enhancing Skin Hydration and Antioxidant Activity

Oxidative stress and antioxidant strategies in dermatology

The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review

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