Antioxidants in patients with hyperthyroidism

Mayer, Ljiljana; Romić, Željko; Škreb, Franjo; Bačić-Vrca, Vesna; Čepelak, Ivana; Žanić‐Grubišić, Tihana; Kirin, Marijan

doi:10.1515/cclm.2004.028

Cited by 27 publications

(19 citation statements)

References 25 publications

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“…These observations are also in agreement with previous findings. [43][44][45] Interestingly, the isolated compound at the dose of 10mg/kg prevented the oxidative damage in both the cardiac and hepatic tissues with an increase in antioxidants in hyperthyroid rats suggesting its free radical scavenging activity.…”

Section: Discussionmentioning

confidence: 91%

Effect of Digoxigenin-3-O-rutin isolated from Trigonella foenum graecum on T4-induced hyperthyroidism and serum lipid concentrations

Panda¹

2014

Phcog J.

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In this study, effect of digoxigenin-3-O-rutin isolated from the seeds of Trigonella foenum graecum on thyroid hormones and serum lipid concentrations was evaluated in L-thyroxine (L-T 4 )-induced hyperthyroidism in rats. Digoxigenin-3-O-rutin was administered (10mg/kg) to L-thyroxine (L-T 4 )-induced hyperthyroidic rats and alterations in the concentrations of serum thyroid hormones, insulin, glucose, hepatic 5′-monodeiodinase (5′DI) and glucose-6-phosphatase (G-6-Pase) activity were analyzed. Antioxidant status was estimated by determining the levels of antioxidative enzymes and lipidperoxidation. L-T 4 (500μg/kg, s.c./d) administration increased the serum levels of thyroxine (T4), triidothyronine (T3), glucose, insulin, different lipids, activity of hepatic 5′-DI and G-6-Pase. High lipidperoxidation level was observed both in liver and cardiac tissues with a depletion in cellular antioxidants. On the contrary, test drug (10mg/kg) treatment improved the alterations with respect to hormonal levels, lipid concentrations and lipid peroxidation towards normalcy and enhanced the antioxidant activities. Rats treated with PTU generally gave lower results compared to groups treated with the test drug. The antithyroidic role of the test compound is mediated possibly through the inhibition in 5′DI activity. Improvement in lipid profile by the test drug might have protective effect on cardiovascular health in vivo.

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Section: Discussionmentioning

confidence: 91%

Effect of Digoxigenin-3-O-rutin isolated from Trigonella foenum graecum on T4-induced hyperthyroidism and serum lipid concentrations

Panda¹

2014

Phcog J.

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“…Andryskowski and Owczarek [13] found that, SOD activity in erythrocytes of patients treated for hyperthyroidism was 11% greater than in the euthyroid population; however, this difference did not reach statistical significance. But other researchers observed the SOD activity in erythrocytes of persons with hyperthyroidism recorded decreased activity [14,15]. But some other researchers observed an increased activity of SOD in patients with hyperthyroidism [16,17].…”

Section: Discussionmentioning

confidence: 94%

“…The ability of normal red cell to withstand hypotonicity results from its biconcave shape, which allows the cell to increase its volume by about 70% before the surface membrane is stretched. Once this limit is reached, lysis occurs [8]. Therefore, measurement of osmotic fragility provides a useful indicator of whether a patient's red cells are normal or not.…”

Section: Introductionmentioning

confidence: 99%

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Erythrocyte osmotic fragility and lipid peroxidation in experimental hyperthyroidism

Yücel

Özdemir

Dariyerli

et al. 2009

Endocr

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This study investigated the relation between erythrocyte osmotic fragility and oxidative stress and antioxidant state in primary hyperthyroidism induced experimental rats. Twenty-four Spraque-Dawley-type female rats weighing between 160 and 200 g were divided into two, as control (n = 10) and experimental (n = 12), groups. The experimental group animals have received tap water and L-Tiroksin (0.4 mg/100 g fodder) added standard fodder for 30 days to induce hyperthyroidism. Control group animals were fed tap water and standard fodder for the same period. Blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T₃, T₄, and TSH levels, osmotic fragility, malondialdehyde (MDA), superoxide dismutase, and glutathione levels were measured in the blood. There was a statistically significant deviation found in maximum and minimum osmotic hemolysis limit values of experimental group when compared to controls. The standard hemolytic increment curve of the hyperthyroid group shifted to the right when compared to control group's curve. There was a statistically significant increase found in MDA and superoxide dismutase, but statistically a significant decrease was detected in glutathione levels in hyperthyroid group when compared to controls. As a result of our study, it may be concluded that hyperthyroidism may led to an increase in osmotic fragility of erythrocytes and this situation may possibly originate from the increased lipid peroxidation in hyperthyroidism.

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“…The regulation of antioxidative defence is multifactorial. Many studies have indicated connections of iodothyronine hormones with oxidative stress [1,4,7,16,20]. NADPH 2 cytochrome P-450 reductase (P-450R), the main enzyme responsible for the doxorubicin-dependent free radical generation, is strictly regulated by triiodothyronine (T3) [8,17] and markedly decreased level of this enzyme (30-50%) was observed in heart of rats treated with methimazole [25,28].…”

Section: Introductionmentioning

confidence: 99%