Antioxidative and Lipid Lowering Effects of 7,8-Dihydroxy-3-(4-methylphenyl) Coumarin in Hyperlipidemic Rats

Abstract

In this study, 7,8-dihydroxy-3-(4-methylphenyl) coumarin (DHMPC), a new coumarin derivative, was tested for the first time to determine whether it had any antioxidant and lipid lowering effects. Hypercholesterolemia was induced by feeding rats with a high cholesterol diet for 17 days. The lipid lowering and antioxidant effects of DHMPC were compared with those of hesperidin (CAS 520-26-3) and rutin (CAS 153-18-4), which have been pharmacologically determined as potential lipid lowering and antioxidant agents. DHMPC significantly decreased total cholesterol levels but not as efficient as hesperidin. When the ratios of high density lipoprotein-cholesterol (HDL-cholesterol) to total cholesterol were evaluated, the most significant changes were observed in DHMPC and rutin treatments. The results of serum triglyceride levels indicate that DHMPC and hesperidin did not significantly decrease triglyceride level when compared to rutin group but prevented it to rise. Serum malondialdehyde (MDA) levels increased as expected in high cholesterol diet groups but no significant decrease was observed for serum MDA levels in all treated groups. In contrast to serum MDA levels, liver homogenates MDA levels decreased in all treated groups but a considerable decrease was not observed for DHMPC treated group. Liver homogenates glutathione (GSH) levels drastically decreased in hyperlipidemic group and increased in all treated groups. As a conclusion DHMPC displayed both antioxidant and lipid lowering effects and can be a candidate drug for further studies.

Antihyperglycemic, Antihyperlipidemic and Antiapoptotic Activities of Micromelum minutum Seeds in Diabetic Rats

“…This process will disallow the slow accumulation of lipids in artery walls. This effect may be attributed to the coumarin contents of the plant seeds which was reported to exhibit lipid lowering effect and significantly decrease total cholesterol level [38][39][40].…”

Current developments of coumarin-based anti-cancer agents in medicinal chemistry

“…1). Coumarins, a part of flavonoid group of plant secondary metabolite, are a wide class of natural and synthetic compounds that showed versatile pharmacological activities including anti-inflammatory [10], antioxidant [11], antinociceptive [12], hepatoprotective [13], antithrombotic [14], antiviral [15], antimicrobial [16,17], antituberculosis [18], anti-carcinogenic [19], antidepressant [20], antihyperlipidemic [21] and anticholinesterase [22] activities.…”

Synthesis and antifungal activity of new dihydrofurocoumarins and dihydrofuroquinolines

“…They possess many biological activities varying from anticancer, 1 anti-HIV, 2,3 anti-Alzheimer, 4,5 antiviral, 6 antimicrobial, 7,8 antioxidant, 9 anti-inflammatory, 10 antituberculosis, 11 anti-influenza, 12 and antihyperlipidemic. 13,14 Moreover, Warfarin is a 4-hydroxycoumarin derivative that has been used as an anticoagulant drug for a long time. In addition, scopoletin 15 and esculatin 16 were found in nature and they have antiproliferative, antioxidant, and anti-inflammatory activities ( Figure 1).…”