Antioxidative Effect of Rice Bran Oil and Medium Chain Fatty Acid Rich Rice Bran Oil in Arsenite Induced Oxidative Stress in Rats

Sengupta, A. K.; Ghosh, Mahua; Bhattacharyya, Dipak Kumar

doi:10.5650/jos.ess14128

Cited by 20 publications

(16 citation statements)

References 28 publications

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“…These findings, coupled with the direct inhibitory effect of C10 on AMPA receptors 6 , provide mechanistic evidence whereby C10 could elicit seizure control. The anti-seizure properties of C10 are further supported by observations, in vivo, that report that mice fed with a C10-enriched chow display significantly improved seizure tolerance and brain antioxidant capacity [7][8][9][10][11] . In studies conducted by Wlaź et al, C10 levels were also determined in the brains of mice following C10-enriched feeding.…”

Section: Introductionmentioning

confidence: 73%

“…The antiseizure properties of C10 are further supported by observations, in vivo, that mice fed with a C10-enriched chow display significantly improved seizure tolerance and brain antioxidant capacity. [7][8][9][10][11] In studies conducted by Wla z et al, 9,10 C10 levels were also determined in the brains of mice following C10-enriched feeding. Interestingly, the concentration of C10 in mouse brain was found to average 240-250 lM, corresponding with therapeutic levels reported in patient plasma on the MCT KD, as well as the optimum concentration (250 lM) for mitochondrial proliferation in our previous studies.…”

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confidence: 99%

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Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium‐chain triglyceride ketogenic diet

et al. 2017

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No. of tables: 1 2 SUMMARY Objective: The medium chain triglyceride ketogenic diet contains both octanoic (C8) and decanoic (C10) acids. The diet is an effective treatment for pharmacoresistant epilepsy. Whilst the exact mechanism for its efficacy is not known, it is emerging that C10, but not C8, interacts with targets that can explain anti-seizure effects, e.g. peroxisome proliferator-activated receptor-γ (PPARγ) (eliciting mitochondrial biogenesis and increased antioxidant status) and the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. For such effects to occur, significant concentrations of C10 are likely to be required in the brain. Methods:In order to investigate how this might occur, we measured the β-oxidation rate of 13 C-labelled C8 and C10 in neuronal SH-SY5Y cells using isotope-ratio mass spectrometry. The effects of carnitine palmitoyl transferase I (CPT1) inhibition, with the CPT1 inhibitor etomoxir, on C8 and C10 β-oxidation were also investigated.Results: Both fatty acids were catabolised, as judged by 13 CO2 release. However, C10 was β-oxidised at a significantly lower rate; 20% of C8. This difference was explained by a clear dependence of C10 on CPT1 activity, which is low in neurons, whereas 66% of C8 β-oxidation was independent of CPT1. In addition, C10 β-oxidation was decreased further in the presence of C8.Significance: It is concluded that, since CPT1 is poorly expressed in the brain, C10 is relatively spared from β-oxidation and can accumulate. This is further facilitated by the presence of C8 in the MCT ketogenic diet, which has a sparing effect upon C10 β-oxidation.

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Section: Introductionmentioning

confidence: 73%

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confidence: 99%

Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium‐chain triglyceride ketogenic diet

et al. 2017

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“…The imbalance between ROS and antioxidants induces oxidative stress, resulting in the retardation of growth in livestock 36 . According to a previous study, MCFA (caprylic, capric, and lauric)-rich rice bran oils ameliorate arsenite-induced oxidative stress in rats 37 .…”

Section: Discussionmentioning

confidence: 96%

Function of capric acid in cyclophosphamide-induced intestinal inflammation, oxidative stress, and barrier function in pigs

Lee

Kang²

2017

Sci Rep

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The small intestine is not only critical for nutrient absorption, but also serves as an important immune organ. Medium-chain fatty acids have nutritional and metabolic effects and support the integrity of the intestinal epithelium. However, their roles in intestinal immunity in pigs are not fully understood. We investigated the effects of a medium-chain fatty acid, capric acid, on intestinal oxidative stress, inflammation, and barrier function in porcine epithelial cells and miniature pigs after treatment with the immune suppressant cyclophosphamide. Capric acid alleviated inflammatory cytokine production (TNF-α and IL-6) and related gene expression (NF-κB, TNF-α, IFN-γ), alleviated oxidative stress (GSSG/GSH ratio, H2O2, and malondialdehyde), and increased oxidative stress-related gene expression (SOD1 and GCLC) in cyclophosphamide-treated IPEC-J2 cells. The permeability of FD-4 and expression of ZO-1 and OCLN in cyclophosphamide-treated IPEC-J2 cells were reduced by capric acid. Dietary capric acid reduced TNF-α, IL-6, and MDA levels and increased SOD, GPx, and the expression of genes related to pro-inflammatory, oxidative stress, and intestinal barrier functions in cyclophosphamide-treated miniature pigs. These results revealed that capric acid has protective effects against cyclophosphamide-induced small intestinal dysfunction in pigs.

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“…Even though rice bran has been reported, studies comparing RBOs are few. Sengupta et al [ 34 ] reported an antioxidative effect of RBO in arsenite-induced oxidative stress in rats by improvement of CAT, SOD, GPx, and GR activity and the inhibition of lipid peroxidation. The present study shows that RBO obtained from coloured rice (Riceberry) also reduced hepatotoxicity and exhibited antioxidant activities in mice given an overdose of APAP.…”

Section: Discussionmentioning

confidence: 99%

Comparative Studies on the Hepatoprotective Effect of White and Coloured Rice Bran Oil against Acetaminophen‐Induced Oxidative Stress in Mice through Antioxidant‐ and Xenobiotic‐Metabolizing Systems

Phannasorn

Chariyakornkul

Sookwong

et al. 2021

Oxidative Medicine and Cellular Longevity

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Rice bran oil (RBO) comprises various nutrients and phytochemicals which exhibit several health benefits. There are no studies regarding the functional effects of different colours of RBO. This study was aimed to compare the constituents and antioxidant activities of white rice bran oil (WRBO) and coloured rice bran oil (CRBO). Each RBO showed similar free fatty acid profiles. However, greater amounts of vitamin E, phytosterols, carotenoids, and chlorophylls were found in CRBO, which had lower γ-oryzanol content than WRBO. Oxidative stress was induced in male mice by an overdose of acetaminophen (APAP) at 300 mg/kg body weight. The mice were then fed with RBO at the equivalent dose to 100 mg/kg body weight of γ-oryzanol three hours later and sacrificed six hours after APAP treatment. The administration of 100 mg γ-oryzanol equivalent in CRBO ameliorated APAP-induced hepatotoxicity in mice more strongly than 100 mg γ-oryzanol equivalent in WRBO, as evidenced by the significant reduction of serum ALT, hepatocellular necrosis, and hepatic lipid peroxidation. CRBO could improve xenobiotic-metabolizing and antioxidant enzyme activities, including glutathione S -transferase, superoxide dismutase, glutathione peroxidase, and glutathione reductase, and also increase mRNA expression of various antioxidant-responsive genes. Vitamin E, phytosterols, carotenoids, and chlorophyll might be the protective compounds in CRBO that alleviate APAP-induced hepatotoxicity through the interruption of APAP metabolism and the activation of antioxidant systems at both transcriptional and enzymatic levels. These findings might provide a protective role of CRBO on oxidative stress associated with several degenerative diseases.

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Antioxidative Effect of Rice Bran Oil and Medium Chain Fatty Acid Rich Rice Bran Oil in Arsenite Induced Oxidative Stress in Rats

Cited by 20 publications

References 28 publications

Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium‐chain triglyceride ketogenic diet

Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium‐chain triglyceride ketogenic diet

Function of capric acid in cyclophosphamide-induced intestinal inflammation, oxidative stress, and barrier function in pigs

Comparative Studies on the Hepatoprotective Effect of White and Coloured Rice Bran Oil against Acetaminophen‐Induced Oxidative Stress in Mice through Antioxidant‐ and Xenobiotic‐Metabolizing Systems

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