Antioxidative effects of quercetin-glycosides isolated from the flower buds of Tussilago farfara L.

Kim, Miran; Lee, Jun Young; Lee, Hyang-Hee; Aryal, Dipendra Kuma; Kim, Yoon Gyoon; Kim, Sang Kyum; Woo, Eun‐Rhan; Kang, Keon Wook

doi:10.1016/j.fct.2006.02.007

Cited by 89 publications

(52 citation statements)

References 34 publications

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“…Similar results were obtained by [43]. In this study, the ability of quercetin to increase the activities of SOD, CAT, and GP X may be due to the free radical scavenging action of quercetin, which may result from the presence of the 3-hydroxyl group in the C-ring and the 3', 4' dihydroxy group in the B-ring [44].…”

Section: Lipid Peroxidation and Antioxidant Enzymessupporting

confidence: 77%

Protective Potential of Quercetin on Cd-Induced Hepatorenal Damage

Sedky¹,

Mahboub²,

Eid³

2017

Pol. J. Environ. Stud.

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Section: Lipid Peroxidation and Antioxidant Enzymessupporting

confidence: 77%

Protective Potential of Quercetin on Cd-Induced Hepatorenal Damage

Sedky¹,

Mahboub²,

Eid³

2017

Pol. J. Environ. Stud.

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“…The glycosides were identified based on the characteristic NMR signals. The analysis of the NMR data and comparison with those reported in the literature led to the structural assignments of the compounds as quercetin-3-O-b-D-glucopyranoside (4) (Gudej 2003;Kim et al 2006), kaempferol-3-O-a-L-rhamnopyranoside (5) (de Almeida et al 1998), quercetin-3-O-a-L-rhamnopyranoside (quercetrin) (6) and quercetin-3-O-b-Darabinopyranoside (7) (Gudej 2003;Kim 2006) (Figure 1). This is also the first report of the isolation of these compounds from this plant species.…”

Section: Resultsmentioning

confidence: 99%

Modulation of intracellular expression of IFNγ and IL-2 in culture of splenic T lymphocytes by some flavonoid glycosides ofAlchornea floribunda

Okoye

Odimegwu

Nworu

et al. 2016

Pharmaceutical Biology

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Context Alchornea floribunda Mü ll. Arg. (Euphorbiaceae) leaves are widely used in ethnomedicine for the management of rheumatism, arthritis and toothache. Objective In this study, flavonoid glycosides isolated from Alchornea floribunda were screened for their effect on the intracellular expression of interferon-gamma (IFNg) and interleukin-2 (IL-2) type-1 cytokines. Materials and methods Chromatographic purification of the ethyl acetate fraction of the methanol leaf extract led to the isolation of seven flavonoid glycosides (1-7). Their structures were elucidated by 1D and 2D nuclear magnetic resonance and mass spectrometry. Splenocytes were treated with graded concentrations of the compounds (6.25-25 mg/mL) and incubated for 24 h. Thereafter, their effect on the expression of IFNg and IL-2 by CD4 + and CD8 + T-lymphocytes was evaluated using intracellular cytokine staining and FACS analysis. Results Compounds 1-7 (6.25-25 mg/mL) caused the up-regulation of activated CD8 + (57.85-72.45% versus 57.85% for untreated control) and, to a lesser extent, activated CD4 + (3.21-7.21% versus 2.75% for the untreated control) T-lymphocytes that were both largely interferon-gammareleasing in treated mouse T lymphocytes relative to untreated control. FACS data analysis showed that stimulation with all the compounds increased the proportion of CD8 + /IFNg + and CD4 +

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“…Then the shade dried aerial parts were extracted with 70% MeOH. The 70% MeOH extract was then subjected to repeated column chromatography on MCI gel CHP20P, Sephadex LH20, octadecyl silica (ODS) and silica gel to afford two new flavonoids, (2R,3S)- 4) luteolin (10), 7) quercetin (11) 4) quercetin 3-O-b-D-glucopyranoside (12) 8) and genkwanin 5-O-primeveroside (13) 6) ( Fig. 1).…”

Section: Notementioning

confidence: 99%