Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L

Abstract

Three novel 2,3-diaryl indone derivatives, ascomindones A−C (1−3), and two new isobenzofuran derivatives, ascomfurans A (4) and B (5), together with four know compounds (6−9) were isolated from the culture of a mangrove-derived fungus Ascomycota sp. SK2YWS-L. Their structures were elucidated on the interpretation of spectroscopic data. 1 and 4 were further constructed by analysis of X-ray diffraction. Antioxidant properties based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical scavenging activities and the ferric reducing ability power (FRAP) of the new compounds were assayed. All of them exhibited significant effects, of which 1 showed more potent activity than ascorbic acid in scavenging DPPH radical with IC50 value of 18.1 μM.

Dichloroisocoumarins with Potential Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Ascomycota sp. CYSK-4

“…Fungi in the genus Ascomycota sp. produce various structurally novel metabolites, including ascomindones A–C and ascomfurans A–B [ 1 ], ascomycotin A [ 2 ], wortmannilactone E [ 3 ], orsellinic acid [ 4 ], isosclerone [ 5 ], and chaetocyclinone [ 6 ]. Furthermore, most of these compounds possess a wide range of biological activities.…”

“…Furthermore, most of these compounds possess a wide range of biological activities. For example, polyketone ascomindones A exhibited more potent capacity in scavenging DPPH radical [ 1 ]. Diphenyl ether barceloneic acid A showed modest inhibition of FPTase enzyme [ 7 ].…”

Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01

“…The DPPH· scavenging was assayed according to the reported method [30]. The DPPH radical scavenging test was performed in 96-well microplates.…”

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

“…Also presented in Table 3 is the pharmacological activity (IC 50 for enzyme or receptor inhibition) of marine-derived compounds , although their respective mechanisms of action remained undetermined and will require further investigation: sponge Aaptos aaptos alkaloid 9-methoxyaaptamine (261) [285]; mangrove-derived fungus Ascomycota sp. SK2YWS-L polyketide ascomindone A (262) [286]; mudflat-derived fungus Aspergillus niger polyketide aurasperone B (263) [287]; alga-derived fungi Penicillium thomii and Penicillium lividum meroterpenoid austalide H acid ethyl ester (264) [288]; fungus Biscogniauxia mediterranea peptide biscogniauxone (265) [289]; fungus Aspergillus ustus sesterpenoid cerebroside D (266) [290]; sponge Spongia ceylonensis diterpene ceylonin A (267) [291]; sponge-derived fungus Stachybotrys chartarum sesquiterpene chartarene D (268) [292]; sponge-associated fungus Talaromyces stipitatus KUFA 0207 anthraquinone citreorosein (269) [293]; fungus Aspergillus sp. SCSIOW3 polyketide cordyol (270) [294]; fungus Chaetomium cristatum dioxopiperazine alkaloid cristazine (271) [295]; sponge-associated fungus Emericella variecolor polyketides diasteltoxins A-C (272)(273)(274) [296]; sponge Latrunculia sp.…”