Antioxidative role of selenium on some tissues of (Cd2+, Cr3+)-induced rainbow trout

Örün, İbrahim; Talas, Zeliha Selamoğlu; Özdemır, İlknur; Alkan, Aysel; Erdoğan, Kenan

doi:10.1016/j.ecoenv.2007.07.008

Cited by 68 publications

(35 citation statements)

References 24 publications

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“…Preventive effects of selenite on heavy metal-induced stress in rainbow trout Oncorhynchus mykiss were described by Ates et al (2008) and Orun et al (2008).…”

Section: Seleniummentioning

confidence: 99%

Metals as a cause of oxidative stress in fish: a review

Ševčíková¹,

Modrá²,

Slaninova³

et al. 2011

Vet. Med.

323

123

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ABSTRACT:This review summarizes the current knowledge on the contribution of metals to the development of oxidative stress in fish. Metals are important inducers of oxidative stress in aquatic organisms, promoting formation of reactive oxygen species through two mechanisms. Redox active metals generate reactive oxygen species through redox cycling, while metals without redox potential impair antioxidant defences, especially that of thiol-containing antioxidants and enzymes. Elevated levels of reactive oxygen species lead to oxidative damage including lipid peroxidation, protein and DNA oxidation, and enzyme inactivation. Antioxidant defences include the enzyme system and low molecular weight antioxidants. Metal-binding proteins, such as ferritin, ceruloplasmin and metallothioneins, have special functions in the detoxification of toxic metals and also play a role in the metabolism and homeostasis of essential metals. Recent studies of metallothioneins as biomarkers indicate that quantitative analysis of mRNA expression of metallothionein genes can be appropriate in cases with elevated levels of metals and no evidence of oxidative damage in fish tissue. Components of the antioxidant defence are used as biochemical markers of oxidative stress. These markers may be manifested differently in the field than in results found in laboratory studies. A complex approach should be taken in field studies of metal contamination of the aquatic environment. Keywords: ROS; metallothioneins; glutathion; superoxide dismutase; antioxidant defenceList of abbreviations ALA-D = aminolevulinic acid dehydratase; BNF = β-naphthoflavone; CAT = catalase; GPx = glutathione peroxidise; GR = glutathione reductase; GSH = glutathione; GSSG = glutathione disulphide; GST = glutathione S-transferase; LPO = lipid peroxidation; MDA = malondialdehyde; MTs = metallothioneins; NADPH = nicotinamidadeninedinucleotide phosphate (reduced); ROS = reactive oxygen species; SOD = superoxide dismutase

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“…Preventive effects of selenite on heavy metal-induced stress in rainbow trout Oncorhynchus mykiss were described by Ates et al (2008) and Orun et al (2008).…”

Section: Seleniummentioning

confidence: 99%

Metals as a cause of oxidative stress in fish: a review

Ševčíková¹,

Modrá²,

Slaninova³

et al. 2011

Vet. Med.

323

123

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“…Pokusi na odraslim životinjama upućuju na to da suplementacija Se (solima selenita) u jetri i bubregu snižava (20, 43, 64-66, 80, 108) ili ne mijenja (45, 100, 109) razinu lipidne peroksidacije nastale djelovanjem Cd. U istraživanjima na kalifornijskim pastrvama primijećen je pozitivan učinak Se u smislu smanjenja lipidne peroksidacije u srcu, slezeni i jetri riba izloženih Cd (97). Aktivnost enzima GSH-Px (20, 61, 64, 79, 100) i SOD (66,67,110) u jetri i bubrezima glodavaca viša je pri istodobnoj izloženosti Se i Cd s obzirom na razinu aktivnosti kada su životinje izložene samo Cd.…”

Section: Utjecaj Se Na Izlučivanje CDunclassified

“…Prema rezultatima iz literature, suplementacija Se uglavnom ne utječe na aktivnost KAT uz istodobnu izloženost Cd u odnosu na aktivnost pri izloženosti samo Cd (61,66,67,100). U srcu, slezeni i jetri riba Se je povećao aktivnosti GSH-Px, SOD i KAT, inače smanjene zbog izloženosti Cd, do vrijednosti bliskih kontrolnim vrijednostima (97).…”

Section: Utjecaj Se Na Izlučivanje CDunclassified

Cadmium and Selenium Interaction in Mammals

Lazarus

2010

Archives of Industrial Hygiene and Toxicology

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Izloženost kadmiju neizbježna je zbog njegove sveprisutnosti u okolišu kao prirodne sastavnice Zemljine kore i kao onečišćenja. Kadmij može izazvati toksične učinke u gotovo cijelom organizmu vezanjem za biološke strukture i nakupljanjem u tkivima, poticanjem stvaranja slobodnih radikala, kao i međudjelovanjem s esencijalnim elementima, često u obliku antagonizma. S druge strane, dodatnim unosom esencijalnih elemenata može se utjecati na raspodjelu i štetne učinke kadmija. Selenij je esencijalan mikroelement i antioksidans, a zbog svojstva vezanja za kadmij (kao i živu, arsen i druge toksične elemente) te uloge u detoksifi kaciji, detaljnije se počelo istraživati međudjelovanje kadmija i selenija. U radu je dan pregled dosadašnjih saznanja o toksikokinetici i toksikodinamici kadmija, biokinetici i biodinamici selenija i mehanizmima njihova međudjelovanja proizašlih uglavnom iz istraživanja na životinjama i ograničenu broju istraživanja u ljudima. Različite doze i odnos doza, način i dužina izloženosti kadmiju i seleniju u pokusima na životinjama uzrok su često vrlo oprečnih rezultata istraživanja opisanih u literaturi. Buduća istraživanja međudjelovanja kadmija i selenija treba usmjeriti na osjetljive skupine stanovništva i na istraživanje mehanizama tog međudjelovanja. Doze i izloženost u pokusima na životinjama treba prilagoditi dugotrajnim i niskim razinama izloženosti koje su najčešće u ljudi. Kadmij (Cd) toksičan je metal čije prirodne razine u okolišu već desetljećima povećavaju industrijski i agrokulturni izvori (1). Osim toga, zbog naglog razvoja modernih tehnologija, gdje se Cd upotrebljava u CdSe/CdTe-kombinacijama, primjerice, u proizvodnji fotonaponskih solarnih ćelija i nanomaterijala za biološke aplikacije, možemo, uz dosadašnje razine onečišćenja okoliša kadmijem, u budućnosti očekivati i povišenja tih razina (2). Iz tla Cd se apsorbira u biljke, a prehrambenim lancem dalje prenosi i akumulira u životinjama i čovjeku. Glavni izvor Cd u općoj populaciji je hrana, posebno žitarice (riža i pšenica), povrće, školjke i iznutrice, kao i duhanski dim (3). Utjecaj Cd na zdravlje ljudi ovisi o brojnim čimbenicima, među kojima o spolu, dobi, prehrani, reproduktivnom stanju te nasljeđu (4) i obuhvaća štetne učinke u bubrezima, jetri, plućima, gušterači, spolnim organima uključujući posteljicu, kostima te kardiovaskularnom, imunosnom i hematopoetskom sustavu (5-8). Osim toga, Cd je klasificiran kao kancerogen prve skupine (9). Uvođenjem biomarkera izloženosti i biomarkera učinaka te unapređenjem analitičkih metoda za mjerenje Cd pokazano je da se već u znatnom dijelu odrasle populacije nepušača iz neonečišćenih područja mogu naći razine Cd koje dokazano izazivaju promjene u bubrezima i kostima (1). Stoga bi se izloženost Cd morala smanjiti, ili ako to nije moguće, trebalo bi smanjiti štetne učinke već apsorbiranog Cd primjenom neke učinkovite i neškodljive tvari.S tim ciljem do sada su provedena mnoga istraživanja, i to uglavnom poticanjem vezanja

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“…reported over the last few years (Orun et al 2007;Virgili and Marino 2008;Emerling et al 2009;Ma et al 2009;Diehn et al 2009). ROS are generated from cell oxygen metabolism and can be divided into free radicals (high reactive molecules), such as superoxide anion (O 2 . )…”

mentioning

confidence: 92%

“…In order to protect tissues against oxidative damage caused by prooxidants, there are several lines of antioxidant defenses at the intra-and extracellular level (Finkel and Holbrook 2000;Sureda et al 2004;Orun et al 2007;Hanen et al 2009;Venkatesh et al 2009). …”

mentioning

confidence: 97%

Antioxidant capacity and oxidative damage determination in synovial fluid of chronically damaged equine metacarpophalangeal joint

et al. 2009

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In order to determine oxidative stress in equine joints with degenerative processes, we analyzed synovial fluid (SF) antioxidant capacity and the concentration of oxidative damage biomarkers in healthy and chronically damaged metacarpophalangeal joints. SF samples were collected from joints of thirty 2-5 year-old crossbreed male equine, macroscopically classified at post mortem inspection and later histologically confirmed. The antioxidant capacity was determined measuring uric acid and the concentration of sulfhydryl groups and the total radical trapping antioxidant potential (TRAP). The oxidative damage was determined by assessing malondialdehyde (MDA) and carbonyl protein concentration. TRAP was significantly higher (p < 0.05) in the group with chronic damage (CD). The sulfhydryl groups and concentration of uric acid did not show significant difference between the groups (p > 0.05). Although carbonyl concentration did not show significant difference between groups, it was slightly higher in the group with CD (p = 0.05009). Concentration of MDA did not show significant difference (p > 0.05) between groups. The observed significant increase in TRAP in the group with CD could be related to the participation of components other than protein, sulfhydryl groups, or uric acid coming from degenerating joint tissues. These findings could be helpful for a better understanding of the oxidative stress role in equine joints with chronic degenerative process.

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Antioxidative role of selenium on some tissues of (Cd2+, Cr3+)-induced rainbow trout

Cited by 68 publications

References 24 publications

Metals as a cause of oxidative stress in fish: a review

Metals as a cause of oxidative stress in fish: a review

Cadmium and Selenium Interaction in Mammals

Antioxidant capacity and oxidative damage determination in synovial fluid of chronically damaged equine metacarpophalangeal joint

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