Antiparasitic drugs

Lynn, Randy C.; Duquette, Robert A.

doi:10.1016/b978-0-323-54396-5.00015-5

Cited by 8 publications

(9 citation statements)

References 330 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Deworming agents are the primary method of treatment and prevention against dog parasites (Coles & Lynn, 2014). Parasiticides are currently the second largest segment of the global animal health market after biologics, at €7 billion (23 % market share) (Selzer & Epe, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…(Lanusse et al, 2018). At the same time, levamisole is a highly effective drug that has a nematocidal effect against Toxascaris, Toxascaris, Ancylostoma, Uncinaria, Angiostrongylus vasorum, Capillaria aerophilia, Crenosoma vulpis), elurostrongylus (Aelurostrongylus abstrusus), olulanus (Ollulanus tricuspis) in dogs and cats (Bolt et al, 1994;Coles & Lynn, 2014;Lanusse et al, 2018). In addition to antihelminthic action, levamisole at the molecular level has antitumor, anti-inflammatory, and antioxidant effects (Renoux, 1980;Chandy et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of levamisole against nematode infestations in dogs

Yuskiv,

Tishyn,

Yuskiv

2024

Ukr. Jour. of Vet. and Agr. Sci.

View full text Add to dashboard Cite

For endoparasitic infestations of dogs, drugs based on levamisole hydrochloride are used. That is why the purpose of the work was to conduct a field study to evaluate the effectiveness of the studied drug “Levamizole O.L.KAR 10 %” and the reference drug “Levamizole-plus 10 %” against endoparasitic infestations of dogs of different breeds, ages, and sexes. According to the results of a parasitological examination of the dogs of the experimental and control groups, endoparasites established spontaneous damage, the causative agents of nematodes of the alimentary canal: species Toxocara canis with an intensity of invasion (II) from 110 to 180 eggs in one gram of feces (EGF) with an average intensity of invasion of 149.0 ± 5.62 EGF, species Toxascaris leonina with an intensity of invasion from 75 to 131 EGF with an average intensity of invasion of 104.4 ± 4.85 EGF and the species Ancylostoma caninum with an intensity of invasion from 48 to 92 EGF with an average intensity of invasion of 69.9 ± 3.71 EGF. Clinically, nematodes of the alimentary canal in dogs were manifested by poor appetite, depressed state, pallor of mucous membranes, mild diarrhea, vomiting, and weight loss observed in some animals. Based on the obtained results, it was established that the studied drug “Levamizol O.L.KAR 10 %” and the reference drug “Levamizol-plus 10 %” when deworming dogs have a pronounced nematodocidal effect against endoparasites of the alimentary canal, which are caused by the following species: Toxocara canis, Toxascaris leonine, Ancylostoma caninum. Thus, the effectiveness of the studied drug “Levamizol O.L.KAR 10 %” for spontaneous toxocariasis infestation in dogs on the seventh day after deworming was 93 %. The reference drug “Levamizol-plus 10 %” was 91 %, and on the 14th day after deworming the animals, the effectiveness of the drugs was 100 %. For spontaneous toxascarosis infestation in dogs, the efficacy of the studied drug “Levamizol O.L.KAR 10 %” on the seventh day after deworming was 95 %. The reference drug “Levamizol-plus 10 %” was 94.4%, and on the 14th day after deworming the animals, the effectiveness of the drugs was 100 %. Helminthological studies have established that for spontaneous hookworm infestation in dogs on the 7th and 14th day after deworming with the study drug and the comparison drug in the recommended doses, the effectiveness of veterinary drugs was 100 %. Field tests showed that the studied drug “Levamizol O.L.KAR 10 %” and the reference drug “Levamizol-plus 10 %” when administered once orally in the recommended doses of the manufacturer, are well tolerated by animals regardless of breed, age, sex, and body weight, not have a toxic effect on the body of animals and are effective against nematodes of the alimentary canal in dogs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of levamisole against nematode infestations in dogs

Yuskiv,

Tishyn,

Yuskiv

2024

Ukr. Jour. of Vet. and Agr. Sci.

View full text Add to dashboard Cite

show abstract

“…Despite the wide range of existing drugs for the prevention and treatment of helminthic infestations, the morbidity of wild and domestic ruminants remains very significant, and the effectiveness of antihelmintic treatments needs to be higher (Lynn & Duquette, 2021). This is related to the irrational use of anthelmintics, their incorrect selection, the development of resistance in helminths, concomitant diseases, and non-compliance with the recommendations regarding veterinary and sanitary measures for the enclosure of ungulates.…”

Section: Discussionmentioning

confidence: 99%

Helminthоfauna of red deer (Cervus elaphus) and fallow deer (Dama dama) in the farm of the Western Polissia of Ukraine

Hunchak

Yuskiv

2023

Ukr. Jour. of Vet. and Agr. Sci.

View full text Add to dashboard Cite

Host animals – red deer (Cervus elaphus) and European fallow deer (Dama dama) for industrial cultivation in the conditions of the “Amila” farm in the Western Polissia of Ukraine can be the primary source of the spread of the helminthic infestation. Following this, in September 2022, samples of feces from a red deer (n = 22) and a European fallow deer (n = 5) were collected for coprological research. During the helminthological study of red deer from five lineages (Eastern European, English, Hungarian, Latvian crossbred, Lithuanian crossbred) in farms, Ostertagia leptospicularis mint eggs were found in faeces in 72.7 % of animals at an intensity of infestation of 6.0 ± 2.1 to 19.3 ± 5.6 EGF. As part of a two-component associative invasion, the species of helminth Ostertagia leptospicularis crossed together with the species Cooperia oncophora (18.2 %). In samples of deer feces, the intensity of Cooperia oncophora egg infestation ranged from 3.5 ± 1.5 to 4.5 ± 2.5 EGF. In the European fallow deer, a coprological examination of collected faecal samples revealed helminth eggs of Ostertagia leptospicularis in 80.0 % of animals with an average infestation intensity of 7.3 ± 2.6 EGF. As part of a two-component associative infestation, the helminth species Ostertagia leptospicularis ran together with the Tricostrongylus axei (20.0 %). The intensity of infestation with eggs of the helminth Trichostrongylus axei averaged 2.5 ± 0.5 EGF. However, in this study, the helminthic infestation was observed in most wild ruminants, but the average infestation intensity was low. In contrast to our previous study on the species distribution of parasites of red deer (Cervus elaphus), the relative abundance and prevalence of nematode eggs: Trichostrongylus, Ostertagia, Coperia, Habertia, Haemonchus, Aonchotheca (capillaria), Strongyloides and Mulleria larvae were generally much higher before deworming in animals on a deer farm. Our findings indicate that the potential for transmission of helminthic infestations is relatively low if monitoring studies on parasite infestation of wild ruminants and their planned deworming are carried out periodically.

show abstract

“…Furthermore, the prevalence of ear mite infestations is highest in young individuals owing to transmission from the queen to the kitten. 15,20,47,48 However, feline cystadenomatosis is more commonly found in cats that are middle-aged and older and could support a possible senile or degenerative change in the tissue or its associated structures, and be less supportive of a congenital etiology. 22 The finding of neoplastic conditions in 17% of the cases is in line with what has previously been reported in the literature, where the mean age of onset for malignant ear tumors (such as ceruminous adenocarcinoma and squamous cell carcinoma) is 11 years.…”

Section: Discussionmentioning

confidence: 99%

Feline cystadenomatosis affecting the ears and skin of 57 cats (2011–2019)

Loft

Soohoo²,

Simon

et al. 2021

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Objectives This study aimed to understand epidemiological factors associated with feline cystadenomatosis, including signalment and papillomavirus PCR status. Cystadenomatosis is an uncommon condition primarily involving the ceruminous and apocrine skin and ear glands. Methods This was a retrospective case series. Clinical records from 2011 to 2019 from a tertiary referral hospital in Boston, MA, USA were screened for cases, and case data were re-evaluated and analyzed. The total patient pool contained 65,385 individual cats, of which 797 were referred to the dermatology service. Medical records and biopsy specimens were reviewed; the information collected included signalment, clinical signs, physical examination and diagnostic tests, comorbidities and histopathologic findings. PCR was performed on biopsy specimens to test for papillomavirus DNA. Results The cystadenomatosis population consisted of 57 cases (7.1% of total cases referred to the dermatology service) with 105 affected ears. Twenty-seven cases (48 ears) were confirmed via histopathology; four cats (7%) exhibited clinically cystic lesions on the periocular, periorbital and perianal regions; only one cat did not have pinnal lesions. Domestic shorthair cats were most often affected. Relative risk for cystadenomatosis was 2.24 times higher in male cats. In 48 cats (84.2%), ears were bilaterally affected. Seven cats (12.3%) had malignant neoplasia, which included: inflamed adenocarcinoma (n = 5); mast cell tumor (n = 1); or squamous cell carcinoma (n = 1). PCR testing on biopsy specimens from 24 cats revealed feline papillomavirus type 2 DNA in only four cats. Conclusions and relevance Cystadenomatosis was more prevalent in senior non-purebred cats, over-represented in male cats and did not appear to be associated with papillomavirus, feline infectious peritonitis, feline immunodeficiency virus/feline leukemia virus status or other identifiable illnesses. Further studies are needed to investigate the causes of cystadenomatosis.

show abstract

Antiparasitic drugs

Cited by 8 publications

References 330 publications

Efficacy of levamisole against nematode infestations in dogs

Efficacy of levamisole against nematode infestations in dogs

Helminthоfauna of red deer (Cervus elaphus) and fallow deer (Dama dama) in the farm of the Western Polissia of Ukraine

Feline cystadenomatosis affecting the ears and skin of 57 cats (2011–2019)

Contact Info

Product

Resources

About