Antiperoxidative properties of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats

Melo, Radamés Bezerra; Guimarães, Sérgio Botelho; Silva, Paulo Goberlânio de Barros; Oriá, Reinaldo B.; Melo, José Ulisses de Souza; Vasconcelos, Paulo Roberto Leitão de

doi:10.1590/s0102-86502014000600004

Cited by 8 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reaction was halted after 5 min by adding sulfuric acid, and the plates were then read in a spectrophotometer (450 nm). Changes in absorbance were plotted on a neutrophil standard curve and expressed as neutrophils/mg of tissue [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial

et al. 2022

View full text Add to dashboard Cite

Objective The aim of this study is to compare the effect of photobiomodulation with low-level laser therapy (LLLT) and nimesulide on inflammatory parameters, biomarkers of oxidative stress and inflammation, and quality of life after lower third molar (L3M) surgery. Material and methods A randomized, two-factor, triple-blind, controlled, split-mouth clinical trial was performed with 40 volunteers who required bilateral L3M removal. Patients were allocated depending on the use or not of 100 mg nimesulide 1 hbefore surgery, as well as the use or not of LLLT in the preoperative period. Results Pain peaks occurred after 6 h (nimesulide-placebo [N-P] group) and 8 h (nimesulide group). In the N-P group, LLLT resulted in significantly lower mean pain scores than the subgroup without LLLT after 4 h ( p = 0.009) and 6 h ( p = 0.048). As for edema, a shorter distance between the mandibular angle and the outer canthus of the eyes after 7 days ( p = 0.037) and a smaller cumulative effect ( p = 0.036) were observed in the N-P group associated with LLLT. A direct effect between LLLT ( p = 0.047) and a reduction in the mean scores of overall dissatisfaction with quality of life was detected. Conclusions Preemptive use of nimesulide only delayed peak pain. LLLT reduced edema, trismus, and contributed to a better perception of quality of life. Nimesulide inhibits peroxidation by increasing GSH and stopping neutrophil migration. The benefit of the association of both strategies was not superior to the use of LLLT alone. Clinical relevance Translational study with impact on clinical-surgical protocols involving L3M surgery related to pharmacological and non-pharmacological methods.

show abstract

Section: Methodsmentioning

confidence: 99%

Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial

et al. 2022

View full text Add to dashboard Cite

show abstract

“…15,16 After anaesthesia (ketamine 90 mg/kg and xylazine 10 mg/ kg, intraperitoneally), dissection of the first left lower molar was performed with a conventional dental explorer, using a Hollenback 3S extraction spatula and a LeCron Zalle spatula as the-moving lever. [15][16][17][18] All surgical procedures were performed blinded by a single, previously trained operator. From the beginning of the protocol animals were randomly chosen and and stomach (p = 0.0168) in a dose-dependent manner, and the animals treated with ZA showed a lower rate of weight gain (p < 0.0001).…”

Section: Experimental Protocol and Analysis Of Surgical Difficultymentioning

confidence: 99%

Effect of different doses of zoledronic acid in establishing of bisphosphonate-related osteonecrosis

Silva

Ferreira

Teófilo

et al. 2015

Archives of Oral Biology

Self Cite

View full text Add to dashboard Cite

“…Currently, there is solid evidence supporting the concept that the intake of nutrients with a specific focus may improve the final results by modulating the immune, metabolic and oxidative stress response [33][34][35][36] .…”

Section: Discussionmentioning

confidence: 99%

Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating NF-kB and Ki-67

Campelo

Brito³

et al. 2015

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE:To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury. METHODS:Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 (ALA + DHA from seaweed). The thermal injury was involving total thickness of skin. After the burns animals received the oil mixes for seven days. The lesions were evaluated by immunohistochemistry.RESULTS: Animals receiving mix 3 showed a smaller extension of the thermal injury as compared to those that were supplemented with other oils mixes. Expression of Ki-67 in the receiving Mix 3 increased as compared to all the other groups. Animals supplemented with mix 3 were able to inhibit NF-κB in injured tissue. CONCLUSION:Rats received oil mix in which the source of ω3 (ALA+DHA of seaweed) showed inhibition of NF-κB, increase in cell proliferation, and reduction the extension of thermal lesion.Key words: Burn. Fatty Acids. Seaweed. Docosahexenoic Acid. alpha-Linolenic Acid. Rats.Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating

show abstract

Antiperoxidative properties of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats

Cited by 8 publications

References 23 publications

Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial

Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial

Effect of different doses of zoledronic acid in establishing of bisphosphonate-related osteonecrosis

Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating NF-kB and Ki-67

Contact Info

Product

Resources

About