Antiproliferative and Anti-Inflammatory Activity From Aerial Parts of Psychotria Cupularis (Rubiaceae) / Atividade Antiproliferativa E Anti-Inflamatória Das Partes Aéreas De Psychotria Cupularis (Rubiaceae)

Abstract

The crude extract and fractions of aerial parts from Psychotria cupularis, collected at Camacan (Brazil), were tested for anti-inflammatory and antiproliferative activity. A phytochemical screening indicated the presence of tannins, anthraquinones, triterpenes, steroids and flavonoids. The crude extract and fractions inhibited the ear oedema in mice between 50.2 to 87.2% and the myeloperoxidase enzyme activity between 51.6 to 97.1%. The butanolic and ethyl acetate fractions was active against glioma, breast, ovary, kidney, colon and leukaemia cell line (IG50 = 4.3 to 16.9 μg/mL).