Antiproliferative and antimitotic effect, S phase accumulation and induction of apoptosis and necrosis after treatment of extract from Rhodiola rosea rhizomes on HL-60 cells

Aqueous extract of Rhodiola imbricata rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro

“…The chemotherapeutic drug adriamycin is known to induce pronounced liver dysfunction, adding R. rosea extract to a protocol with adriamycin resulted in an improved inhibition of tumor dissemination and the combined protocol prevented liver toxicity (Udintsev et al, 1992). Majewska et al (2006) have also reported that extract of R. rosea rhizomes inhibits cell division, induction of apoptosis and necrosis, and showed a cytostatic, antiproliferative effect in HL-60 cells. In our previous studies, we reported that RAE has immunostimulatory potential and anti-cancer activity (Mishra et al 2006(Mishra et al , 2008.…”

Aqueous extract of Rhodiola imbricata rhizome inhibits proliferation of an erythroleukemic cell line K-562 by inducing apoptosis and cell cycle arrest at G2/M phase

“…The chemotherapeutic drug adriamycin is known to induce pronounced liver dysfunction, adding R. rosea extract to a protocol with adriamycin resulted in an improved inhibition of tumor dissemination and the combined protocol prevented liver toxicity (Udintsev et al, 1992). Majewska et al (2006) have also reported that extract of R. rosea rhizome inhibits cell division, induction of apoptosis and necrosis, and showed cytostatic and anti-proliferative effects in HL-60 cells. In our previous study, we reported that Rhodiola aqueous extract (RAE) treatment of human peripheral blood mononuclear cells (PBMCs) caused increased production of IL-6 and tumor necrosis factor-a (TNF-a) via phosphorylated IkB and transcription factor NF-kB showing its immunostimulatory potential .…”

Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention

“…Thus a better understanding of the diverse modes of cell death in cancer therapy will provide a molecular basis for new strategies targeting death pathways. A wide range of putative cancer-chemopreventive plant extracts in particular Glycyrrhiza uralensis, Sologrum nigrum, Pereskia bleo, Cratoxylum cochinchinense, Rhodiola rosea, Physalis peruviana, Betulla platyphylla (Jo et al, 2005;Ju et al, 2004;Majewska et al, 2006;Tan et al, 2005;Tang et al, 2004;Wu et al, 2004) has been suggested to induce apoptosis in neoplastic cells (Table 3). The apoptotic effect of the ethanolic extract of P. peruviana in human HepG2 cells resulted from the collapse of the mitochondrial membrane permeability and depletion of glutathione .…”

“…Literature data has indicated that apoptosis can be induced by the multitude of bioactive constituents in the herbal extracts. Organosulfur compounds, phenolic acids, resveratrol, flavonoids have been shown to induce apoptosis in a number of cancer cell lines (Majewska et al, 2006;Son et al, 2003;Tan et al, 2005;Tang et al, 2004). Resveratrol produced a significant induction of p21 expression that resulted in cell cycle blockade at the S phase and apoptosis induction in MCF-7 breast cancer cells (Pozo-Guisado et al, 2002).…”