Antiproliferative and Apoptotic Potential of Methotrexate Lipid Nanoparticles in A Murine Breast Cancer Model

Surve, Chaitali; Banerjee, Ananya; Chakraborty, Rajasree; Kumar, Dhiraj; Butti, Ramesh; Gorain, Mahadeo; Parida, Sabyasachi; Kundu, Gopal C.; Shidhaye, Supriya; Patnaik, Srinivas

doi:10.2217/nnm-2021-0446

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…Unfortunately, SLNs have limitations in drug loading efficiency and drug release controllability, and further optimization is needed. 39 In brief, SLNs are natural delivery platforms for various anticancer drugs (paclitaxel, methotrexate, and doxorubicin), [40][41][42] antimicrobials (lacticin 3147, antimicrobial peptides, and tea tree oil), [43][44][45] and central nervous system drugs (ivermectin, campthotecin, and clozapine), 46,47 and other drugs, with fantastic development prospects.…”

Section: The Family Of Lipid Nanoparticlesmentioning

confidence: 99%

Looking back, moving forward: protein corona of lipid nanoparticles

Gao,

Huang,

Ren

et al. 2024

J. Mater. Chem. B

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Section: The Family Of Lipid Nanoparticlesmentioning

confidence: 99%

Looking back, moving forward: protein corona of lipid nanoparticles

Gao,

Huang,

Ren

et al. 2024

J. Mater. Chem. B

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“…Currently, polymer and lipid-based hybrid NPs are being explored for their potential to deliver MTX in various disorders. Such hybrid NPs have high (Kumar et al, 2022) biocompatibility with improved blood circulation time (Surve et al, 2022). Also, these systems can further be modified in response to specific stimuli, including redox potential, pH, and temperature (Teixeira et al, 2017;Kumar et al, 2022;Chang et al, 2023).…”

Section: Stimuli-responsive Lipid-based Nanoparticlesmentioning

confidence: 99%

Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review

Mukhtar,

Ezra Manicum,

Shojaei Barjouei

et al. 2023

Front. Biomater. Sci.

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Cancer is one of the most life-threatening family of diseases that cause death worldwide. As a highly researched and successful therapeutic agent, methotrexate (MTX) treats many solid tumours, hematologic malignancies, and autoimmune illnesses. Despite many benefits, methotrexate induces drug resistance and limits plasma half-life due to its poor pharmacokinetics. The variable biological availability have prompted researchers to investigate innovative delivery strategies for enhancing its therapeutic qualities. To develop more suitable methotrexate formulations, nanoparticles (NPs) have recently gained a significant interest. A wide range of nanoparticles, including polymer-based nanoparticles, carbon-based nanoparticles, lipid-based nanoparticles, as well as inorganic nanoparticles, can be deliver cancer chemotherapeutics such as methotrexate. Loading methotrexate into NPs can provide a delivery system that has shown great promise to carcinoma therapy. In this review, we will describe the feasibility of NP-based strategies to deliver methotrexate in cancer therapy, outlining the current state of the art and the challenges/promises for the future.

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“…However, significant disadvantages limiting the effectiveness of methotrexate are poor solubility, a short half-life, and rapid diffusion throughout the body [12]. To solve these problems and improve clinical application of the drug, conjugation of methotrexate with nanoparticles was proposed, which showed beneficial effects [13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Evolution of Gold and Iron Oxide Nanoparticles in Conjugates with Methotrexate: Synthesis and Anticancer Effects

et al. 2023

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Au and Fe nanoparticles and their conjugates with the drug methotrexate were obtained by an environmentally safe method of metal–vapor synthesis (MVS). The materials were characterized by transmission and scanning electron microscopy (TEM, SEM), X-ray photoelectron spectroscopy (XPS), and small-angle X-ray scattering using synchrotron radiation (SAXS). The use of acetone as an organic reagent in the MVS makes it possible to obtain Au and Fe particles with an average size of 8.3 and 1.8 nm, respectively, which was established by TEM. It was found that Au, both in the NPs and the composite with methotrexate, was in the Au0, Au+ and Au3+ states. The Au 4f spectra for Au-containing systems are very close. The effect of methotrexate was manifested in a slight decrease in the proportion of the Au0 state—from 0.81 to 0.76. In the Fe NPs, the main state is the Fe3+ state, and the Fe2+ state is also present in a small amount. The analysis of samples by SAXS registered highly heterogeneous populations of metal nanoparticles coexisting with a wide proportion of large aggregates, the number of which increased significantly in the presence of methotrexate. For Au conjugates with methotrexate, a very wide asymmetric fraction with sizes up to 60 nm and a maximum of ~4 nm has been registered. In the case of Fe, the main fraction consists of particles with a radius of 4.6 nm. The main fraction consists of aggregates up to 10 nm. The size of the aggregates varies in the range of 20–50 nm. In the presence of methotrexate, the number of aggregates increases. The cytotoxicity and anticancer activity of the obtained nanomaterials were determined by MTT and NR assays. Fe conjugates with methotrexate showed the highest toxicity against the lung adenocarcinoma cell line and Au nanoparticles loaded with methotrexate affected the human colon adenocarcinoma cell line. Both conjugates displayed lysosome-specific toxicity against the A549 cancer cell line after 120 h of culture. The obtained materials may be promising for the creation of improved agents for cancer treatment.

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Antiproliferative and Apoptotic Potential of Methotrexate Lipid Nanoparticles in A Murine Breast Cancer Model

Cited by 4 publications

References 36 publications

Looking back, moving forward: protein corona of lipid nanoparticles

Looking back, moving forward: protein corona of lipid nanoparticles

Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review

Evolution of Gold and Iron Oxide Nanoparticles in Conjugates with Methotrexate: Synthesis and Anticancer Effects

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