Antispasmodic effects of a new kaurene diterpene isolated from Croton argyrophylloides on rat airway smooth muscle

Aguiar, Liza Araújo; Porto, Romulo Sousa; Lahlou, Saad; Ceccatto, Vânia Marilande; Barbosa, Roseli; Lemos, Telma L. G.; Santos, Hélcio Silva dos; Coelho‐de‐Souza, Andrelina Noronha; Magalhães, Pedro Jorge Caldas; Zin, Walter A.; Leal-Cardoso, José Henrique

doi:10.1111/j.2042-7158.2012.01494.x

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Regardless of the detailed mechanism of their inhibitory actions, there is likely to be a relevant link between the effects of these croton derivatives on electrically excitable cells and their inhibitory effects on HCN channel activity, though croton-03-mediated effect on HCN channels might not be isoform-specific. It is tempting to speculate that the blocking by these ent-kaurane-type diterpenoids of I h plays an important role in modulating the functional activities of neurons and neuroendocrine or endocrine cells [5,6]. Therefore, croton derivatives and other structurally related ent-kaurane-type diterpenoids would be the harbinger of intriguing compounds that use the open/activated state of the HCN channels as a substrate.…”

Section: Discussionmentioning

confidence: 99%

“…The essential oil of C. nepetaefolius was reported to reverse histamine-induced firing in guinea-pig celiac ganglion [5]. The diterpene isolated from C. argyrophylloides was demonstrated to exert antispasmodic effects in airway smooth muscle [6].…”

Section: Introductionmentioning

confidence: 99%

“…For example, either crofelemer or SP-300, a purified proanthocyanidine oligomer extracted from the South American medicinal plant C. lechleri (dragon's blood), has been demonstrated to depress Clcurrents in colonic epithelial cells [7,8]. The diterpene isolated from C. argyrophylloides could block voltage-gated Ca 2+ channels in airway smooth muscle cells [6].…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Inhibitory Effectiveness in Hyperpolarization-Activated Cation Currents by a Group of ent-Kaurane-Type Diterpenoids from Croton tonkinensis

Kuo

Liu

et al. 2020

IJMS

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Croton is an extensive flowering plant genus in the spurge family, Euphorbiaceae. Three croton compounds with the common ent-kaurane skeleton have been purified from Croton tonkinensis. Methods: We examined any modifications of croton components (i.e., croton-01 [ent-18-acetoxy-7α-hydroxykaur-16-en-15-one], croton-02 [ent-7α,14β-dihydroxykaur-16-en-15-one] and croton-03 [ent-1β-acetoxy-7α,14β-dihydroxykaur-16-en-15-one] on either hyperpolarization-activated cation current (Ih) or erg-mediated K+ current identified in pituitary tumor (GH3) cells and in rat insulin-secreting (INS-1) cells via patch-clamp methods. Results: Addition of croton-01, croton-02, or croton-03 effectively and differentially depressed Ih amplitude. Croton-03 (3 μM) shifted the activation curve of Ih to a more negative potential by approximately 11 mV. The voltage-dependent hysteresis of Ih was also diminished by croton-03 administration. Croton-03-induced depression of Ih could not be attenuated by SQ-22536 (10 μM), an inhibitor of adenylate cyclase, but indeed reversed by oxaliplatin (10 μM). The Ih in INS-1 cells was also depressed effectively by croton-03. Conclusion: Our study highlights the evidence that these ent-kaurane diterpenoids might conceivably perturb these ionic currents through which they have high influence on the functional activities of endocrine or neuroendocrine cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of Inhibitory Effectiveness in Hyperpolarization-Activated Cation Currents by a Group of ent-Kaurane-Type Diterpenoids from Croton tonkinensis

Kuo

Liu

et al. 2020

IJMS

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“…The biological properties of various Croton species have been investigated in laboratory studies involving murine models [3,4,5,6,7,8,9,10]. The chemical composition of Croton is somewhat diverse, although alkaloids [11,12], diterpenoids [13,14] and volatile oils comprising mono- and sesquiterpenoids [15,16,17,18], have been commonly reported.…”

Section: Introductionmentioning

confidence: 99%

Effects of Croton rhamnifolioides Essential Oil on Aedes aegypti Oviposition, Larval Toxicity and Trypsin Activity

et al. 2014

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Although numerous reports are available concerning the larvicidal potential of essential oils, very few investigations have focused on their mechanisms of action. In the present study, we have investigated the chemical composition of the leaf oil of Croton rhamnifolioides during storage and its effects on oviposition and survival of larvae of the dengue fever mosquito Aedes aegypti. In addition, we have established a possible mechanism of action for the larvicidal activity of the essential oil. GC-MS analyses revealed marked differences in the composition of oil that had been freshly isolated and that of a sample that had been stored in a sealed amber-glass vial under refrigeration for three years. However, both fresh and stored oil exhibited substantial larvicidal activities with LC50 values of 122.35 and 89.03 ppm, respectively, and oviposition deterrent effects against gravid females at concentrations of 50 and 100 µg·mL . These results demonstrate that the larvicidal effect of the essential oil was unchanged during three years of storage even though its chemical composition altered. Hence, the essential oil could be used in the preparation of commercial products. In addition, we observed that the trypsin-like activity of mosquito larvae was OPEN ACCESSMolecules 2014, 19 16574 inhibited in vitro by the essential oil of C. rhamnifolioides, suggesting that the larvicidal effect may be associated with inhibition of this enzyme.

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A New 1,6-Seco-Norisoprenoid from the Leaves and Twigs of Croton yanhuii

Li,

Guo,

et al. 2024

Chem Nat Compd

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Antispasmodic effects of a new kaurene diterpene isolated from Croton argyrophylloides on rat airway smooth muscle

Cited by 7 publications

References 35 publications

Characterization of Inhibitory Effectiveness in Hyperpolarization-Activated Cation Currents by a Group of ent-Kaurane-Type Diterpenoids from Croton tonkinensis

Characterization of Inhibitory Effectiveness in Hyperpolarization-Activated Cation Currents by a Group of ent-Kaurane-Type Diterpenoids from Croton tonkinensis

Effects of Croton rhamnifolioides Essential Oil on Aedes aegypti Oviposition, Larval Toxicity and Trypsin Activity

A New 1,6-Seco-Norisoprenoid from the Leaves and Twigs of Croton yanhuii

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