Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report

Abstract

Background There have been no reports on the effectiveness of the administration of antithrombin III (AT III) for post-transplant portal vein thrombosis (PVT). We herein report a case of post-transplant PVT that was resolved by AT III treatment after living donor liver transplantation (LDLT). Case presentation The patient was a 57-year-old man who had been diagnosed with decompensate liver cirrhosis by hepatitis C virus infection. He presented with repeated hepatic coma and refractory ascites. Computed tomography (CT) revealed PVT of Yerdel classification grade II before LDLT. He underwent ABO-identical LDLT using a right lobe graft. A liver function test revealed elevated liver enzyme levels on post-operative day (POD) 14. The CT examination on POD 15 revealed PVT in the left side of the main portal vein at the side of left gastric vein ligation. AT III treatment from POD 15 to POD 24 was performed. Magnetic resonance imaging revealed that the PVT had decreased 10% on POD 27. Furthermore, AT III treatment from POD 28 to POD 32 was performed. The CT examination demonstrated the disappearance of PVT on POD 69 and thereafter, he had no recurrence of PVT on 10 post-operative month (POM). Conclusions The present case suggests that the administration of AT III is safe and suitable for the treatment of post-transplant PVT.

Protein C in a patient with portal vein thrombosis in liver transplantation

“…Профилактика как первичных, так и рецидивных тромбозов при ортотопической трансплантации печени (ОТП) является наиболее эффективным средством предупреждения потери трансплантата и смерти пациентов [6]. Несмотря на проводимую терапию нефракционированным или низкомолекулярным гепарином, антитромбином (АТ) III, распространенность ТВВ, ТПВ, ТПА у пациентов, перенесших трансплантацию печени, составляет от 3 до 7% [7][8][9].…”