Antitumor Activities of<i>O</i>-Sulfonated Derivatives of (1→3)-α-<scp>D</scp>-Glucan from Different<i>Lentinus edodes</i>

Surenjav, Unursaikhan; Xu, Xiaojuan; Zeng, Fanbo; Zhang, Lina

doi:10.1271/bbb.70.38

Cited by 34 publications

(15 citation statements)

References 17 publications

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“…When applied to the Sarcoma 180 cell culture, their significant anti-tumor activity was observed. Similar results concerning increased biological activity were shown in relation to modified ␣-d-glucans from Lentinus edodes [38] and Agrocybe cylindracea [36]. Therefore, to achieve higher biological activity, in our study, we used carboxymethylated derivatives of (1 → 3)-␣-d-glucans isolated from the G. lucidum species.…”

Section: Discussionsupporting

confidence: 76%

Biological study on carboxymethylated (1→3)-α-d-glucans from fruiting bodies of Ganoderma lucidum

Wiater

Paduch

Choma

et al. 2012

International Journal of Biological Macromolecules

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Section: Discussionsupporting

confidence: 76%

Biological study on carboxymethylated (1→3)-α-d-glucans from fruiting bodies of Ganoderma lucidum

Wiater

Paduch

Choma

et al. 2012

International Journal of Biological Macromolecules

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“…Despite β-glucan polysaccharide has been regarded as the responsible agent for this effect, most of the related studies have used either crude extracts (Lee et al , 2003; Wong et al , 2007; Harhaji et al , 2008) or a fraction of extracts (Ohno et al , 2001; Nakamura et al , 2004; Sarangi et al , 2006; Unursaikhan et al , 2006). …”

Section: Resultsmentioning

confidence: 99%

Extracellular polysaccharide production by a strain of Pleurotus djamor isolated in the south of Brazil and antitumor activity on Sarcoma 180

Borges¹,

Barba²,

Schiebelbein³

et al. 2013

Braz. J. Microbiol.

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Polysaccharides with medicinal properties can be obtained from fruiting bodies, mycelium and culture broth of several fungus species. This work was carried out in batch culture using a stirred tank reactor with two different initial glucose concentrations (40–50 g/L) and pH values (3.0–4.0) to enhance extracellular polysaccharides production by Pleurotus djamor UNIVILLE 001 and evaluate antitumor effect of intraperitonial administration of Pleurotus djamor extract on sarcoma 180 animal model. According to factorial design, the low pH value (pH 3.0) led to a gain of 1.6 g/L on the extracellular polysaccharide concentration, while glucose concentration in the tested range had no significant effect on the concentration of polysaccharide. With 40 g/L initial glucose concentration and pH 3.0, it was observed that yield factor of extracellular polysaccharide on substrate (YP/S = 0.072) and maximum extracellular polysaccharide productivity (QPmax = 11.26 mg/L.h) were about 188% and 321% respectively higher than those obtained in the experiment performed at pH 4.0. Under these conditions, the highest values of the yield factor of biomass on substrate (YX/S = 0.24) and maximal biomass productivity (QXmax = 32.2 mg/L.h) were also reached. In tumor response study, mean tumor volume on the 21th day was 35.3 cm3 in untreated group and 1.6 cm3 in treated group (p = 0.05) with a tumor inhibition rate of 94%. These impressive results suggests an inhibitory effect of P.djamor extract on cancer cells.

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“…The water solubility of polysaccharide was increased and its pharmacological activity was also improved accordingly. Therefore, it is possible to enhance the antitumor activity of water soluble polysaccharides by proper chemical modification of increasing solubility 38 , 39 . It is reported that after partial carboxymethylation, both the water solubility and the anti tumor activity of the water insoluble β - (1→3)-D dextran increased.…”

Section: Discussionmentioning

confidence: 99%

Structure elucidation and antitumor activity of a new polysaccharide from Maerkang Tricholoma matsutake

Hou¹,

Ding²,

Hou³

et al. 2017

Int. J. Biol. Sci.

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A new heteropolysaccharide was isolated from the fruiting bodies of Tricholoma matsutake which had a molecular weight of 12078 Da. The results of structural features analysis showed that T. matsutake polysaccharide, here named TMP-B, was mainly composed of α - D - glucose and α - D - galactose which ratios were 7:2 and had a backbone of 1, 4 - linked α - D - glucose which branches were mainly composed of two 6 - linked α - D - galactose residue, and the α - D - galactose was 1, 6 - linked. Antitumor activity results showed that heteropolysaccharide TMP-B could inhibit the growth of S180 tumor in vivo and promote the apoptosis of L929 cells in vitro. Immunoregulatory activity results showed that TMP-B could promote the proliferation of macrophages by affecting G0/G1 phase, S phases and G2/M phases and promote cytokines release and gene expression. The result of this study introduced Maerkang T. matsutake as a possible valuable source which helped to exhibit unique antitumor and immunoregulatory properties.

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Antitumor Activities ofO-Sulfonated Derivatives of (1→3)-α-D-Glucan from DifferentLentinus edodes

Cited by 34 publications

References 17 publications

Biological study on carboxymethylated (1→3)-α-d-glucans from fruiting bodies of Ganoderma lucidum

Biological study on carboxymethylated (1→3)-α-d-glucans from fruiting bodies of Ganoderma lucidum

Extracellular polysaccharide production by a strain of Pleurotus djamor isolated in the south of Brazil and antitumor activity on Sarcoma 180

Structure elucidation and antitumor activity of a new polysaccharide from Maerkang Tricholoma matsutake

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