Antitumor agents. Schiff bases from benzaldehyde nitrogen mustards and 2-phenyl-4-[(3-amino-4-methoxy)phenyl]thiazole

“…With (T/ C) values of 150 or above, the median survival time of the control group is 30 days. [13] The urea containing thiazole and its compound associated with ethyl Thendry ethyl-p-isocyanato-benzoate 5 was added in anhydrous benzene, and the mixture was refluxed for 2 h to get the desired product 6. "A suspension of 6, in aqueous Na 2 CO 3 , and 10 mL of EtOH was stirred overnight to get compound 7 (Scheme 2).…”

Section: The First Decade (1970-1980)mentioning

confidence: 99%

Thiazole as an Indispensable Scaffold in Anti‐Leukemic Agents: A Semicentennial Review

Sharma,

Das,

Jadhav

et al. 2024

ChemistrySelect

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Leukemia affects the body‘s blood‐forming tissues, especially the bone marrow and lymphatic system. Leukemia incidence varies between communities and between pathological kinds. Many treatment modalities exist for leukemia, such as chemotherapy, targeted therapy, radiation therapy, bone marrow transplantation, immunotherapy, and the engineering of immune cells to fight leukemia. Leukemia might be treated with a variety of pharmaceuticals, the most popular of which are imatinib (Gleevec), dasatinib (Sprycel), nilotinib (Tasigna), obinutuzumab (Gazyva), venetoclax (Venclexta), and so on. Thiazole is one of the scaffolds that are actively explored in leukemia. Derivatives having the thiazole nucleus have been surfacing as potent candidates in the treatment of leukemia for quite sometime now, but a consolidated report accumulating all these ventures is absent. Numerous naturally occurring substances, including flavones, alkaloids, anabolic steroids, and vitamin B1 (thiamine), include the basic thiazole molecule. Thiazole derivatives have been researched for their possible therapeutic effects in the treatment of leukemia. Thus, this review comprising reports regarding the effect of different thiazole‐based species in leukemia is a timely effort to the best of our knowledge. This review covers the chronological development of antileukemic thiazole‐based molecules, their synthesis, biological activity, and structure–activity relationships.

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“…In the last few decades, extensive work has been done on synthesis and biological studies of Schiff bases and their metal-based derivatives Schiff base ligands are excellent coordinating molecules and can exhibit variety in the structure of their metal complexes. Literature survey reveals that Schiff bases have assumed importance in various fields such as coordination chemistry [1], analytical chemistry [2] and pigments, dyes [3] and polymer [4,5] industries; in biochemical researches, especially as model compounds of several vitamins and enzymes [6,7] and in agriculture as fungicides, pesticides and bactericides [8,9]. It has been reported that certain Schiff bases exhibit antitubercular activities [10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Metal Complexes of a N-(Furan-2-Ylmethylidene)- Pyrazine-2-Carboxamide Schiff Base

Mallikarjunaswamy¹,

Sekhar²

2018

Int Res J Pharm

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The Fe(III), Ru(III), Co(II), Ni(II), Cu(II), Pd(II), Zn(II), Cd(II) and Hg(II) complexes of a Schiff base derived from pyrazine-2-carboxamide and furan-2-carbaldehyde (FMPCA: 1) have been synthesized and structurally characterized by various physico-chemical data. The ligand acts as a neutral, bidentate one towards the metal ions coordinating through azomethine nitrogen and furan oxygen. The geometry and the bonding characteristics associated with the complexes have been deduced from relevant spectral data. Consolidating all the data obtained Fe, Ru, Co, Ni and Cu Complexes have been assigned to octahedral geometry, Pd complex, a square planar geometry and the Zn, Cd and Hg complexes tetrahedral in geometry. Further, the ligand and the metal complexes have been screened for their antimicrobial activity, the Hg complex exerting the highest activity.

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Antitumor agents. Schiff bases from benzaldehyde nitrogen mustards and 2-phenyl-4-[(3-amino-4-methoxy)phenyl]thiazole

Abstract: We have already reported several Schiff bases from p-aminophenylthiazoles and benzaldehyde nitrogen mustards as possessing good antitumor activity.2•3

Cited by 11 publications

References 0 publications

Microwave Assisted Synthesis and Spectral Analysis of Schiff Bases Derived from 2-Amino-5-Aryl-1,3,4-Oxadiazoles

Microwave Assisted Synthesis and Spectral Analysis of Schiff Bases Derived from 2-Amino-5-Aryl-1,3,4-Oxadiazoles

Thiazole as an Indispensable Scaffold in Anti‐Leukemic Agents: A Semicentennial Review

Synthesis and Characterization of Metal Complexes of a N-(Furan-2-Ylmethylidene)- Pyrazine-2-Carboxamide Schiff Base

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