Antitumor Polysaccharide Lentinan—A T Cell Adjuvant2

Dennert, Günther; Tucker, D. F.

doi:10.1093/jnci/51.5.1727

Cited by 61 publications

(15 citation statements)

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“…Together with reported results, the antitumor effect mechanism of C. militaris polysaccharides could be immuno-enhancing activity. Polysaccharides exert their antitumor effects primarily by activating various immune system responses in the host, such as complement system activation (Dennert and Tucker, 1973), macrophage-dependent immune system responses Lee et al, 2010), and upregulation of interferon expression (Hamuro and Chihara, 1985).…”

Section: Discussionmentioning

confidence: 99%

Cordyceps militaris polysaccharide triggers apoptosis and G0/G1 cell arrest in cancer cells

Cheng

Wang

Jin

et al. 2015

Journal of Asia-Pacific Entomology

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Section: Discussionmentioning

confidence: 99%

Cordyceps militaris polysaccharide triggers apoptosis and G0/G1 cell arrest in cancer cells

Cheng

Wang

Jin

et al. 2015

Journal of Asia-Pacific Entomology

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“…There is a significant amount of experimental evidence suggesting that polysaccharides from mushrooms enhance the host immune system by stimulating natural killer cells, T-cells, B-cells, and macrophage-dependent immune system response (Dalmo & Boqwald, 2008;Dennert & Tucker, 1973). Polysaccharides obtained from different natural sources represent a structurally diverse class of macromolecules and exert their antitumor action mostly by activating various immune system responses (Schepetkin & Quinn, 2006).…”

Section: Discussionmentioning

confidence: 99%

Structural characterization of immunostimulating polysaccharide from cultured mycelia of Cordyceps militaris

Lee

Kwon

Yun

et al. 2010

Carbohydrate Polymers

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“…In 1969, Suzuki et al (29,30) revealed that the growth-inhibitory activity of yeast mannan and glucan against sarcoma 180 solid tumor was an immunological event involving stimulation of lymph nodes and spleen cells. Thereafter, lentinan, an antitumor polysaccharide (4), was shown to be a T-cell adjuvant (7,16), inducing a humoral antitumor factor (17). Recently, we reported that A-mannan was found to inhibit the growth ofsolid forms ofsarcoma 180 and Ehrlich carcinoma transplanted in mice, and the growth-inhibition ratio was nearly identical to that of W-mannan (18).…”

Section: Discussionmentioning

confidence: 99%

Mitogenic Effect of the Mannans from Saccharomyces cerevisiae on Mouse Spleen Lymphocytes

Mikami

Nagase

Matsumoto

et al. 1982

Microbiology and Immunology

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The DNA synthetic activities of mannans isolated from two Saccharomyces cerevisiae strains were examined in vitro using spleen cells obtained from normal or nude BALB/c strain mice. A highly branched mannan isolated from the S. cerevisiae wild type strain induced a greater increase in mitogenic activity than those displayed by the mannan of the S. cerevisiae X2l80-IA-5 mutant strain which possessed fewer branching moieties. Acid-hydrolyzed wild type strain mannan with two-thirds of the molecular weight of the parent intact mannan showed weak mitogenicity.Increases in the DNA synthetic activities of nude and normal spleen cells were almost the same as that of wild type strain mannan, while nylon wool column-passed spleen cells obtained from both normal and nude mice did not show mitogenicity with this mannan. The results indicated that the mitogenic activity was responsible for the highly branched structure of the wild type strain mannan, and that this mannan is a B-cell mitogen.It has been shown that several bacterial constituents such as lipopolysaccharides (10), purified protein derivative (28), polymerized ftagerin (5), and dextran sulfate (25), are mitogenic against B cells. There is disagreement, however, in the previous findings concerning the mitogenic potency of dextran, a non-anionic polysaccharide. A few papers reported that dextran had no effect on DNA synthesis (2, 8), but another paper showed that dextrans displayed mitogenic activity (6, 20).We have recently reported that two mannans isolated from Saccharomyces cerevisiae wild type strain (commercially available bakers' yeast) and X2180-lA-5 mutant strain had strong antitumor activities against solid forms of sarcoma 180 and Ehrlich carcinoma (18), and also demonstrated that these mannans were not contaminated with bacterial lipopolysaccharides (19). Results obtained in the preceding study which indicated that the intensity of antitumor activity evoked by the mutant strain mannan (abbreviated as A-mannan) containing very small 913

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Antitumor Polysaccharide Lentinan—A T Cell Adjuvant2

Cited by 61 publications

References 0 publications

Cordyceps militaris polysaccharide triggers apoptosis and G0/G1 cell arrest in cancer cells

Cordyceps militaris polysaccharide triggers apoptosis and G0/G1 cell arrest in cancer cells

Structural characterization of immunostimulating polysaccharide from cultured mycelia of Cordyceps militaris

Mitogenic Effect of the Mannans from Saccharomyces cerevisiae on Mouse Spleen Lymphocytes

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