Antitumour bioactive peptides isolated from marine organisms

Xing, Haibo; Tong, Mengting; Jiang, Nanyu; Zhang, Xiaomin; Hu, Hanping; Pan, Hongming; Li, Da

doi:10.1111/1440-1681.12808

Cited by 11 publications

(7 citation statements)

References 46 publications

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“…Cancer is a disease with high morbidity and mortality, which constitutes a serious health burden and a global economic burden. 104,105 Conventional cancer chemotherapy, radiotherapy, and surgery can cause serious side effects. 106 The quality of life of cancer patients declines.…”

Section: Anticancer Peptidesmentioning

confidence: 99%

Recent research progress of biologically active peptides

et al. 2022

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With the rapid development of molecular biology and biochemical technology, great progress has been made in the study of peptides. Peptides are easy to digest and absorb, with lowering of blood pressure and cholesterol, improving immunity, regulating hormones, antibacterial, and antiviral effects. Peptides also have physiological regulation and biological metabolism functions with applications in the fields of feed production and biomedical research. In the future, the research focus of bioactive peptides will focus on their efficient preparation and application. This article introduces a comprehensive review of the types, synthesis, functionalization, and bio‐related applications of bioactive peptides. For this aim, we introduced in detail various biopeptides and then presented the production methods of bioactive peptides, such as enzymatic synthesis, microbial fermentation, chemical synthesis, and others. The applications of bioactive peptides for anticancers, immune therapy, antibacterial, and other applications have been introduced and discussed. And discussed the development prospects of biologically active peptides.

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Section: Anticancer Peptidesmentioning

confidence: 99%

Recent research progress of biologically active peptides

et al. 2022

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“…In fact, the marine environment though somehow mysterious, promotes the fruitful development of a great number of natural products, which may possess novel structures, chemical properties and biological effects [27]. The marine-derived cyclopeptides have received great attention due to their high potency in anti-microbial, anti-inflammatory and anticancer activities [28][29][30][31]. This section mainly discusses the discovery of marine-derived cyclopeptides with anticancer properties in the last 20 years.…”

Section: Marine-derived Anticancer Cyclopeptidesmentioning

confidence: 99%

“…Jaspamide is an early-discovered cyclic depsipeptide from the sponge Jaspis splendens, which delivered pronounced inhibitory activities against breast and prostate cancer cells [31]. Pipestelide A (20), a cyclodepsipeptide derived from the marine sponge Pipestela candelabra, was biosynthetically related to jaspamide.…”

Section: Anticancer Cyclopeptides Derived From Spongementioning

confidence: 99%

Natural Cyclopeptides as Anticancer Agents in the Last 20 Years

Zhang

Xia

Zhang

2021

IJMS

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Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino acids. A large number of natural cyclopeptides have been reported to be highly effective against different cancer cells, some of which are renowned for their clinical uses. Compared to linear peptides, cyclopeptides have absolute advantages of structural rigidity, biochemical stability, binding affinity as well as membrane permeability, which contribute greatly to their anticancer potency. Therefore, the discovery and development of natural cyclopeptides as anticancer agents remains attractive to academic researchers and pharmaceutical companies. Herein, we provide an overview of anticancer cyclopeptides that were discovered in the past 20 years. The present review mainly focuses on the anticancer efficacies, mechanisms of action and chemical structures of cyclopeptides with natural origins. Additionally, studies of the structure–activity relationship, total synthetic strategies as well as bioactivities of natural cyclopeptides are also included in this article. In conclusion, due to their characteristic structural features, natural cyclopeptides have great potential to be developed as anticancer agents. Indeed, they can also serve as excellent scaffolds for the synthesis of novel derivatives for combating cancerous pathologies.

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“…It is a hydrophobic cyclic depsipeptide (solubilized using Cremophor ® ) isolated from the Mediterranean tunicate Aplidium albicans (Fig. ) and marketed by PharmaMar ® under the trade name Aplidin ® . Plitidepsin showed potent pleiotropic actions against a broad spectrum of cancer cell lines and xenograft animal models .…”

Section: Targeting the Tumor Vasculature By Natural Compounds: Perspementioning

confidence: 99%

Starvation tactics using natural compounds for advanced cancers: pharmacodynamics, clinical efficacy, and predictive biomarkers

2018

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The high mortality associated with oncological diseases is mostly due to tumors in advanced stages, and their management is a major challenge in modern oncology. Angiogenesis is a defined hallmark of cancer and predisposes to metastatic invasion and dissemination and is therefore an important druggable target for cancer drug discovery. Recently, because of drug resistance and poor prognosis, new anticancer drugs from natural sources targeting tumor vessels have attracted more attention and have been used in several randomized and controlled clinical trials as therapeutic options. Here, we outline and discuss potential natural compounds as salvage treatment for advanced cancers from recent and ongoing clinical trials and real‐world studies. We also discuss predictive biomarkers for patients' selection to optimize the use of these potential anticancer drugs.

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Antitumour bioactive peptides isolated from marine organisms

Cited by 11 publications

References 46 publications

Recent research progress of biologically active peptides

Recent research progress of biologically active peptides

Natural Cyclopeptides as Anticancer Agents in the Last 20 Years

Starvation tactics using natural compounds for advanced cancers: pharmacodynamics, clinical efficacy, and predictive biomarkers

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