Antiulcerative properties and acute toxicity profile of some African medicinal plant extracts

Noamesi, B. K.; Mensah, Joseph Frank; Bogale, M.; Dagne, Ermias; Adotey, Joseph

doi:10.1016/0378-8741(94)90017-5

Cited by 25 publications

(13 citation statements)

References 7 publications

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“…The brine shrimp assay has been employed widely and found useful in identifying biologically active compounds (Thompson et al 1985;Labbe et al 1989;Konig et al 1990;McLaughlin et al 1991;Aiello et al 1992;Albrizio et al 1992;Anderson et al 1992;Cunsolo et al 1993;Noamesi et al 1994). Given the widespread use, ease and low cost, the brine shrimp assay was also employed in this study.…”

Section: Discussionmentioning

confidence: 99%

Interactions among plant defense compounds: a method for analysis

Nelson

Kursar

1999

Chemoecology

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Plants contain an enormous diversity and quantity of secondary metabolites, some of which are toxic and deterrent to herbivores and pathogens. This impressive diversity of plant compounds suggests a high probability of interactions among them. Synergistic interactions are those in which the combined activity of two or more chemicals is greater than that expected given their individual activities. On the other hand, antagonistic interactions are those in which the combined activity of two or more chemicals is less than that expected given their individual activities. Synergistic interactions could increase plant fitness whereas antagonistic interactions could decrease plant fitness. Interactions are thus potentially very important, not only in explaining the diversity of defense compounds within individual plants, but also in providing insight into plant defense strategies. Although synergistic interactions have received increased attention in the ecological literature in the last decade, the number of documented cases of synergy remains small and antagonistic interactions are rarely considered. The primary reason for this scarcity may be the difficulty of detecting, analyzing and displaying such interactions. Analysis by ANOVA, though sometimes used, often is not appropriate. We introduce a simple technique, isobolographic analysis, that is used in pharmacology for detecting and rigorously quantifying synergy and antagonism and provide an example using the brine shrimp toxicity assay. More statistically sophisticated approaches, such as isobolographic analysis, will allow ecologists to effectively document the role of chemical synergy and antagonism in interactions between species. Such chemical interactions may ultimately provide insight into longstanding, ecological questions.

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Section: Discussionmentioning

confidence: 99%

Interactions among plant defense compounds: a method for analysis

Nelson

Kursar

1999

Chemoecology

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“…Noamesi et al [81] reported that acute cytotoxic concentrations of prekese (438 µg/mL) extracts killed 50% (LC 50 ) of brine shrimp within 24 h. The extract was still effective when applied in conjunction with other extracts Guibourtia ehie and Taverniera abyssinica; however, G. ehie alone did not kill the shrimps even at 2 mg/mL, indicating that prekese contributed significantly to the potent bioactivity. When two species of fish, Tilapia nilotica and T. galilaea, were treated with prekese, both fishes died after 24 h; however, the former showed an LC 50 at 0.35 whereas the latter was 0.44 ppm, indicating differences in the susceptibility to the extract among the fish species [82].…”

Section: Toxicological Aspectmentioning

confidence: 99%

Potential Application of Tetrapleura tetraptera and Hibiscus sabdariffa (Malvaceae) in Designing Highly Flavoured and Bioactive Pito with Functional Properties

Adadi

Kanwugu

2020

Beverages

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Sorghum beer (pito) is an indigenous alcoholic beverage peculiar to northern Ghana and parts of other West African countries. It is overwhelmed with calories, essential amino acids (such as lysine, etc.), B-group vitamins, and minerals. In recent years, there has been a growing demand for highly flavoured yet functional pito in Ghana; however, the local producers lack the prerequisite scientific expertise in designing such products. We propose the utilization of Tetrapleura tetraptera (TT) and Hibiscus sabdariffa (HS) as cheap and readily available materials in designing functional flavoured pito. The addition of TT and HS would not alter the fermentation profile but rather augment the starter with nutrients, thus improving the fermentation performance and shelf life of the final pito. In vitro and in vivo studies provide substantive evidence of antioxidant, nephro-and hepato-protective, renal/diuretic effect, anticholesterol, antidiabetic, and antihypertensive effects among others of the TT and HS, hence enriching the pito with health-promoting factors and consequently boosting the health of the consumer. Herein, we summarise the phytochemical, biological, pharmacological, and toxicological aspects of TT and HS as well as the technology involved in brewing the novel bioactive-flavoured pito. In addition, we also report the incidence of heavy metal in conventional pito.

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“…The hydra and tadpoles were sensitive to the molluscicides except aridanin but the shrimps and anopheline mosquito larvae were resistant to all the molluscicides. Noamesi et al (1994) worked on the aqueous extract of the stem bark of Tetrapleura tetraptera, Guibourtia ehie and the root extract of Taverniera abyssinica used for the treatment of gastrointestinal related clinical proplems in Africa ethnomedicine. An Hcl/EtOH-induced ulceration was used in fasted rat stomach to investigate the antiulcertative properties of the extracts and an acute cytoxoxicity of the extracts using brine shrimp larvae was also investigated.…”

Section: Control Of Schistosomiasis and Fascioliasismentioning

confidence: 99%

<i>Tetrapleura tetraptera</i>: Molluscicidal activity and chemical constituents

Aladesanmi

2007

Afr. J. Trad. Compl. Alt. Med.

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Tetrapleura tetraptera (Schumach. And Thonn) Taub, Mimosaceae, commonly known as Aridan (fruit), A single stemmed, robust, perennial tree of about 30m.It has a grey/brown, smooth/rough bark with glabrous yound branchlets. The flower is yellow/pink and racemes white the fruit has dark brown, four winged pods 12-25 x 3.5-6.5cm.It is generally found in the lowland forest of tropical Africa. The fruit consists of a fleshy pulp with small, brownish-black seeds. The fruit possesses a fragrants, characteristically pungent aromatic odour, which is attributed to its insect repellent property. It is used as spices and aroma (exotic tropical scents) and fish poisoning. It is one of the molluscicidal medicinal plants of Nigeria, also useful in the management of convulsions, leprosy, inflammation and/or rheumatoid pains. The documented biological and-or pharmacological activities are found to be molluscicidal, cardio-vascular, neuromuscular, hypotensive, anti-convulsant, molluscicidal, trypanocidal, hirudinicidal, schistomiasis control, anti-ulcerative, ectoxicity, anti-inflammatory, hypoglycaemic, anti-microbial, emulsifying property, birth control, food value and the control of intestinal parasites. Activity-guided fractionation of the methanol extract of the fruits of T. Tetraptera led to the isolation of a saponin glycoside with an oleanolic acid aglycone, a monodesmosidic diglycoside of the rare sapogenin 27-hydroxyolean-12 (13)-en-28-oic acid; echinocystic acid-3-0-sodium sulfate from the stembark, umbelliferone and ferulic acid from the leaves and branches respectively. Also isolated from the fruits were aridanin and three of its olean-12-en-28-oic acid derivatives. All the compounds isolated either from the fruits or other parts were found to exhibit strong molluscicidal properties against the schistosomiasis-transmitting snails Biomphalaria glabrata.

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Antiulcerative properties and acute toxicity profile of some African medicinal plant extracts

Cited by 25 publications

References 7 publications

Interactions among plant defense compounds: a method for analysis

Interactions among plant defense compounds: a method for analysis

Potential Application of Tetrapleura tetraptera and Hibiscus sabdariffa (Malvaceae) in Designing Highly Flavoured and Bioactive Pito with Functional Properties

<i>Tetrapleura tetraptera</i>: Molluscicidal activity and chemical constituents

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