Antiurease activity of plants growing in the Czech Republic

Hřibová, Petra; Khazneh, Elian; Žemlička, Milan; Švajdlenka, Emil; Ghoneim, Mohammed M.; Elokely, Khaled M.; Ross, Samir A.

doi:10.1080/14786419.2014.888553

Cited by 14 publications

(6 citation statements)

References 21 publications

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“…Urease, an enzyme catalyzing the decomposition of urea into carbon dioxide and ammonia, is one of the virulence factors of many bacteria, among them Helicobacter pylori . As was observed in computational studies (Hřibová et al., ), tiliroside can be a strong inhibitor of urease, with a docking score equal to ‐8.9 kcal/M. However promising, this outcome should be confirmed by further studies.…”

Section: Biological Activities Of Tilirosidementioning

confidence: 72%

A Review on the Dietary Flavonoid Tiliroside

Grochowski

Locatelli

Granica

et al. 2018

Comp Rev Food Sci Food Safe

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Among flavonoid derivatives, tiliroside is a flavonoid contained in several edible plants or specific plant parts (fruits, leaves, or roots). These parts are often widely used as both food and medicines, in the treatment of various ailments and, in some cases, as food supplements. Considering the easy access to many publications concerning tiliroside and the lack of a review that summarizes the current progress in studies on its safety, efficacy, and presence in the plant kingdom, we present here a review paper on tiliroside and its principal derivatives. The paper also highlights the basic knowledge regarding this molecule, its derivatives, and the analytical approaches used for extraction and quantification, as well as reports on the biological activities against different key enzymes linked to various human diseases. The reported information is also devoted to highlighting the concept "learn from nature to discover new products," particularly in the development of new drugs, food supplements, and nutraceuticals, starting from a natural lead compound such as tiliroside and improving its biological activities (and selectivities) against a specific target for therapeutic purposes.

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Section: Biological Activities Of Tilirosidementioning

confidence: 72%

A Review on the Dietary Flavonoid Tiliroside

Grochowski

Locatelli

Granica

et al. 2018

Comp Rev Food Sci Food Safe

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“…Such studies, for example, revealed that B-type PCs (catechin dimers) inhibit urease because, according to their docking scores (−6.9 kcal/mol), they fit the binding pocket of the bacterial enzyme, being these interactions energetically favorable (48). Then, molecular docking could contribute to elucidate the interactions between PCs and other cellular or bacterial targets of interest for the protection of the gastric mucosa against H. pylori .…”

Section: Pacs In the Stomachmentioning

confidence: 99%

The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

et al. 2017

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Proanthocyanidins (PACs) are polymers of flavan-3-ols abundant in many vegetable foods and beverages widely consumed in the human diet. There is increasing evidence supporting the beneficial impact of dietary PACs in the prevention and nutritional management of non-communicable chronic diseases. It is considered that PACs with a degree of polymerization >3 remain unabsorbed in the gastrointestinal (GI) tract and accumulate in the colonic lumen. Accordingly, the GI tract may be considered as a key organ for the healthy-promoting effects of dietary PACs. PACs form non-specific complexes with salivary proteins in mouth, originating the sensation of astringency, and with dietary proteins, pancreatic enzymes, and nutrient transporters in the intestinal lumen, decreasing the digestion and absorption of carbohydrates, proteins, and lipids. They also exert antimicrobial activities, interfering with cariogenic or ulcerogenic pathogens in the mouth (Streptococcus mutans) and stomach (Helicobacter pylori), respectively. Through their antioxidant and antiinflammatory properties, PACs decrease inflammatory processes in animal model of gastric and colonic inflammation. Interestingly, they exert prebiotic activities, stimulating the growth of Lactobacillus spp. and Bifidobacterium spp. as well as some butyrate-producing bacteria in the colon. Finally, PACs are also metabolized by the gut microbiota, producing metabolites, mainly aromatic acids and valerolactones, which accumulate in the colon and/or are absorbed into the bloodstream. Accordingly, these compounds could display biological activities on the colonic epithelium or in extra-intestinal tissues and, therefore, contribute to part of the beneficial effects of dietary PACs.

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“…mechanism-based directed, they affect the catalysis that leads to enzymatic inactivation; several plant-derived urease inhibitors have been described. 8,9 Screening and confirmation studies have demonstrated urease inhibitory activity in gastrointestinal and urinary tract by traditional medicinal plants from China, 10 Pakistan, 11 Iran, 12 Czech Republic, 13 India, 14 and other countries.…”

Section: Introductionmentioning

confidence: 99%

Anti-urease activity of native species of genus Piper from Guatemala with potential application in infection control

Cáceres¹,

Almeda²,

Astorga³

et al. 2018

Int J Phytocos Nat Ingred

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Introduction: Urease is an enzyme that catalyzes the hydrolysis of urea in the gastrointestinal and urinary systems, related with chronic bacterial infection. Piper is a basal angiosperm genus with ethnobotanical application. The aim of this study was to determine urease inhibitory activity of extracts from ten Guatemalan Piper species. Methods: Leaves from 7 species were collected in Suchitepequez (P. amalago, P. auritum, P. hispidum, P. jacquemontianum, P. oradendron, P. retalhuleuense, and P. umbellatum), and 3 in Alta Verapaz (P. psilorhachis, P. sempervirens, and P. variabile), shade-dried and milled. Dichloromethane (DCM) and methanol (MeOH) extracts were prepared by percolation and concentrated by rotavapor. The inhibitory effect was determined by enzymatic assays, qualitative by thin layer chromatography developed by phenol red; and quantitative by spectrophotometric kinetic method evaluated by microcolorimetry at 630 nm with phenol red. Results: Seventeen extracts out of 20 demonstrated anti-urease activity by TLC, showing one discoloration band with Rf 1.4-5.8; P. psilorhachis showed 2 discolorations bands at Rf 5.3 and 5.8, and the best activity (IC 50 MeOH 1.9 ± 0.08 μg/mL and DCM 2.1 ± 06 μg/mL), similar to positive control (hydrocyclohexanone IC 50 1.4 ± 0.05 µg/mL). Two other species, P. umbellatum (IC 50 MeOH 2.5 ± 0.06 µg/mL) and P. retalhuleunse (IC 50 MeOH 4.1 ± 0.7 µg/mL, DCM 4.8 ± 0.06 µg/mL) showed a moderate activity. Conclusion: Three species showed interesting anti-urease activity that deserves future studies by bioguided fractionation. Literature review demonstrated that this is the first report about the urease activity of these Piper species.

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Antiurease activity of plants growing in the Czech Republic

Cited by 14 publications

References 21 publications

A Review on the Dietary Flavonoid Tiliroside

A Review on the Dietary Flavonoid Tiliroside

The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

Anti-urease activity of native species of genus Piper from Guatemala with potential application in infection control

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