Antiviral agents

Swallow, D. L.

doi:10.1007/978-3-0348-7102-0_6

Cited by 6 publications

(14 citation statements)

References 262 publications

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“…Lycorine, one of the principal alkaloids of the Amaryllidacea, exerts an antiviral effect on several RNA and DNA viruses; isolated from Clivia miniata (Amaryllidacea) (Leven et al, 1983). Is a secondary metabolite of Streptomyces species S-885 and is toxic to HeLa cells; has anti-polio activity at 0.02 mg/ml (Swallow et al, 1975).…”

Section: Lycorinementioning

confidence: 99%

“…Found in Olea europaea L. (Oleaceae); exhibit in vitro antiviral activiy against viruses (Swallow et al, 1975). Castelanone is a nortriterpenoid with a quassinoid skeletal type occurs in the root bark of Castela tweediei (Simaroubaceae); exhibits in vitro antiviral activiy against the oncogenic Rous sarcoma virus (Rembold, 1989).…”

Section: Miscellaneous Compoundsmentioning

confidence: 99%

“…Found in the rhizomes of Woodwardia orientalis SW reduces the plaque forming ability of Herpes simplex virus type 1 (HSV-1) and poliovirus (Xu et al, 1993). Two compounds have been used in treatment of acute viral hepatitis; isolated from Silybum marianum (Compositae) (Swallow et al, 1975).…”

Section: Phenolicmentioning

confidence: 99%

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Antiviral Activity of Compounds Isolated From Plants

Pérez¹

2003

Pharmaceutical Biology

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Section: Lycorinementioning

confidence: 99%

Section: Miscellaneous Compoundsmentioning

confidence: 99%

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Antiviral Activity of Compounds Isolated From Plants

Pérez¹

2003

Pharmaceutical Biology

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“…During the last two decades, nucleoside analogues have been explored extensively as antiviral agents [3,6,20,23,24], A nov el approach which evolved from this earli er work was the use of an aliphatic or acyclic side chain to replace the cyclic carbohydrate moiety of the nucleoside. The earliest successful attempts at devel oping antiviral nucleosides with aliphatic side chains are represented by two pu rines; 9-(2' -hydroxyethoxymethyl)-guanine (acyclovir) [7,17] and S-9-(2',3'-dihydroxypropyl)-adenine (DHPA) [4].…”

Section: Introductionmentioning

confidence: 99%

“…Little or no antiherpesvirus activity has been found for several l-(2'-hydroxyethoxymethyl) derivatives of cytosine, or uracil [2,8,9,18] or for l-(2'-aminoethoxymethyl)-uracils [10], We have explored the activity of a number of uracil and cytosine derivatives with one of the following acyclic side chains: 2-hydroxyethoxymethyl, 2-aminoethoxymethyl, or 1,3-dihydroxypropoxymethyl. We primarily concentrated on 5-substitutions as have other investigators [2,9,24], Therefore, a number of ana logues of pyrimidine acyclic nucleosides have been synthesized and analyzed for cell growth inhibitor potency and for anti herpes activity.…”

Section: Introductionmentioning

confidence: 99%

Acyclic Pyrimidine Nucleoside Analogues: Influence on Growth of L5178y Mouse Lymphoma Cells and Antiherpes Activity in KB Cells

et al. 1985

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Several uracil and cytosine nucleoside analogues with 2-hydroxyethoxy-methyl, 2-aminoethoxymethyl or 1,3-dihydroxypropoxymethyl side chains were synthesized and evaluated for cytostatic (L5178y mouse lymphoma cells) and antiviral (herpes simplex virus type 1 infected KB cells) activity. Two compounds exhibited anti-herpesvirus activity. These were 1-(2’-hydroxyethoxymethyl)-5-aza-cytosine and 1-(1’,3’-dihydroxypropoxymethyl)-5-iodouracil. The MIC values were 25.8 and 325.7 μg/ml, respectively.

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Alkaloids as potential antivirals. A comprehensive review

Faisal

Badshah

Kubra

et al. 2023

Nat. Prod. Bioprospect.

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Alkaloids are a diverse group of natural phytochemicals. These phytochemicals in plants provide them protection against pests, and herbivorous organisms and also control their development. Numerous of these alkaloids have a variety of biological effects, and some have even been developed into medications with different medicinal properties. This review aims to provide a broad overview of the numerous naturally occurring alkaloids (isolated from both terrestrial and aquatic species) along with synthetically produced alkaloid compounds having prominent antiviral properties. Previous reviews on this subject have focused on the biological actions of both natural and synthetic alkaloids, but they have not gone into comprehensive detail about their antiviral properties. We reviewed here several antiviral alkaloids that have been described in the literature in different investigational environments i.e. (in-vivo, in-ovo, in-vitro, and in-silico), and found that these alkaloid compounds have significant antiviral properties against several infectious viruses. These alkaloids repressed and targeted various important stages of viral infection at non-toxic doses while some of the alkaloids reported here also exhibited comparable inhibitory activities to commercially used drugs. Overall, these anti-viral effects of alkaloids point to a high degree of specificity, implying that they could serve as effective and safe antiviral medicines if further pursued in medicinal and pharmacological investigations.

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Antiviral agents

Cited by 6 publications

References 262 publications

Antiviral Activity of Compounds Isolated From Plants

Antiviral Activity of Compounds Isolated From Plants

Acyclic Pyrimidine Nucleoside Analogues: Influence on Growth of L5178y Mouse Lymphoma Cells and Antiherpes Activity in KB Cells

Alkaloids as potential antivirals. A comprehensive review

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