Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes from<i>Pimpinella anisum</i>

Lee, Jung‐Bum; Yamagishi, Chihiro; Hayashi, Kyoko; Hayashi, Toshimitsu

doi:10.1271/bbb.100645

Cited by 94 publications

(41 citation statements)

References 21 publications

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“…In addition, LCC contains hydrophobic rigid lignin blocks and hydrophilic flexible polysaccharide blocks, making lignin-carbohydrate complexes have good amphipathy, biocompatibility, and mechanical strength [12]. The lignin and carbohydrate blocks in the LCC copolymer not only have an ideal structure for biomaterials, but also have good compatibility with animal cells [13]. The rigid lignin blocks can form lignin-protein complexes with membrane bound proteins in animal cells, enabling cells to grow [14].…”

Section: Introductionmentioning

confidence: 99%

Lignin-Carbohydrate Complexes Based Spherical Biocarriers: Preparation, Characterization, and Biocompatibility

Zhao

Wang

et al. 2017

International Journal of Polymer Science

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Spherical biocarriers were prepared with lignin-carbohydrate complexes isolated from ginkgo (Ginkgo biloba L.) xylem. The specific surface and average pore size of the biocarriers were 17.15 m 2 g −1 and 21.59 nm, respectively. The carriers were stable in solution at pH 4.0∼9.5. Fourier transform infrared (FT-IR) spectrum indicated that the spherical carrier was composed of lignin and polysaccharides and had a typical lignin-carbohydrate complex (LCC) structure. The contents of galactose, lignin, and total sugar were 3.30%, 23.9%, and 64.62%, respectively, making the spherical biocarriers have good physical strength and compatible with hepatocytes. It was observed using a scanning electron microscopy (SEM) that liver cells adhered to the spherical biocarriers during culture. Cell counting indicated that the proliferation of liver cells in the experimental group was significantly higher than that of the control group. The albumin secretion (ALB) value and glucose consumption of the human hepatocytes were increased by 51.7% and 38.6%, respectively, by the fourth day when cultivated on the biocarriers. The results indicate that ginkgo LCC is very biocompatible and shows promise for the use as a biomaterial in the culture of human hepatocytes.

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Section: Introductionmentioning

confidence: 99%

Lignin-Carbohydrate Complexes Based Spherical Biocarriers: Preparation, Characterization, and Biocompatibility

Zhao

Wang

et al. 2017

International Journal of Polymer Science

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“…More recent work suggested that LCCs from P. anisum show antiviral activities against the herpes simplex virus, human cytomegalovirus and the measles virus [35]. …”

Section: Pharmacological Activities Of Lignins and Their Derivativesmentioning

confidence: 99%

Lignins and Their Derivatives with Beneficial Effects on Human Health

Vinardell

Mitjans

2017

IJMS

197

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A review of the pharmacological applications of lignins provides evidence of their protective role against the development of different diseases. In many cases, the effects of lignins could be explained by their antioxidant capacity. Here, we present a systematic review of the literature from the period 2010–2016 which provides information concerning new applications of lignins derived from recent research. The most promising findings are reported, including the methodologies employed and results obtained with lignins or their derivatives which may improve human health. We highlight potential applications in the treatment of obesity, diabetes, thrombosis, viral infections and cancer. Moreover, we report both that lignins can be used in the preparation of nanoparticles to deliver different drugs and also their use in photoprotection.

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“…Подтверждена эффективность лигнина при инфекционных заболеваниях, вызванных вирусами простого герпеса 1 и 2-го типов, цитомегаловируса, кори и гриппа. В эксперименте на мышах лигнины способство-вали увеличению выработки оксида азота и блокировали синтез провоспалительных цитокинов (IL 1␤, IL 10, TNF ␣) [29,30]. Японские и китайские исследователи сообща-ют о высокой анти-ВИЧ активности лигнин-углеводных комплексов, обусловленной подавлением клеточной адсорбции ВИЧ, ингибированием обратной транскрипта-зы и протеазы [31][32][33].…”

Section: педиатрическая фармакология /2012/ том 9/ №unclassified

Application of Enterosorbents in Clinical Practice

Панфилова¹,

Таранушенко²

2012

Pediatr. farmakol.

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Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes fromPimpinella anisum

Cited by 94 publications

References 21 publications

Lignin-Carbohydrate Complexes Based Spherical Biocarriers: Preparation, Characterization, and Biocompatibility

Lignin-Carbohydrate Complexes Based Spherical Biocarriers: Preparation, Characterization, and Biocompatibility

Lignins and Their Derivatives with Beneficial Effects on Human Health

Application of Enterosorbents in Clinical Practice

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