Anton’s syndrome as a presentation of Trousseau syndrome involving the bilateral optic radiation

Abstract

Anton’s syndrome is a rare neuropsychiatric syndrome that is characterized by cortical blindness and anosognosia with visual confabulation, but without global cognitive impairment. We herein report a rare case of Anton’s syndrome as a presentation of Trousseau syndrome involving the bilateral optic radiation. The patient had been diagnosed with gallbladder cancer 2 months previously, and he was admitted to the hospital with confusion and quadriplegia. He was found to be blind, but denied any visual impairment and demonstrated visual confabulation despite evidence of his blindness. These signs were consistent with a diagnosis of Anton’s syndrome. Brain computed tomography (CT) and magnetic resonance imaging revealed infarcts in the bilateral temporo-parieto-occipital junction with hemorrhagic transformation, mainly involving the bilateral optic radiation. The presence of gallbladder cancer with peripheral metastasis on abdominal CT, as well as markedly increased tumor markers and D-dimer levels, supported the presence of cancer-related hypercoagulability and the diagnosis of Trousseau syndrome.

Network Localization of Awareness in Visual and Motor Anosognosia

“…We identified 24 cases of visual deficits without awareness 2,21–41 (visual anosognosia, see Fig 1, Tables S1, S2), 69 cases of visual deficits with awareness, 11 95 cases of motor deficits without awareness (motor anosognosia), and 79 cases of motor deficits with awareness 1 from several sources. The network of voxels connected to each lesion location was computed and the resulting 267 lesion networks were entered into a single voxelwise ANOVA (see Fig 2).…”