Anwendung der Hochdruck-Flüssigkeits-Chromatographie zur Analyse von Penicillinen und Cephalosporinen

Degradation of Mecillinam in Aqueous Solution

“…The only exception is penicillamine solely derived from the nucleus. The scheme differs from those of previous investigators (27,28) mainly by the incorporation of the 5-epimerization of penicilloic acid. (5s)-Penicilloic acid was not included among their reference compounds.…”

“…Among the schemes found in the literature (2,19,(21)(22)(23)(24)(25)(26)(27)(28)(29), only those of Blaha et al (27) and Hartmann et af. (28) are exclusively based on accurate analyses.…”

“…Among the schemes found in the literature (2,19,(21)(22)(23)(24)(25)(26)(27)(28)(29), only those of Blaha et al (27) and Hartmann et af. (28) are exclusively based on accurate analyses. They followed the formation of a selection of known degradation products of penicillins G and V in aqueous solution as a function of pH, until most of the penicillins were destroyed, by high-pressure liquid chromatography (HPLC) and UV spectroscopy.…”

The quantitative determination of cephalexin by proton magnetic resonance spectroscopy

“…Other assays include i.r. spectroscopy (Wahbi & Unterhalt 1977), fluorometry (Yu et al 1977), high performance liquid chromatography (Hartmann & Rodiger 1976;Carroll et al 1977), and gas-chromatography (Nakagawa et al 1978). spectroscopy (Wahbi & Unterhalt 1977), fluorometry (Yu et al 1977), high performance liquid chromatography (Hartmann & Rodiger 1976;Carroll et al 1977), and gas-chromatography (Nakagawa et al 1978).…”