Anxiety and depression propensities in patients with acute toxic liver injury

Suh, Jeong Ill; Sakong, Jeong Kyu; Lee, Kwan; Lee, Yong Kook; Park, Jeong Bae; Kim, Dong Joon; Seo, Yeon Seok; Lee, Jae Dong; Ko, Soon Young; Lee, Byung Seok; Kim, Seok Hyun; Kim, Byung Seok; Kim, Young Seok; Lee, Heon Ju; Kim, In Hee; Sohn, Joo Hyun; Kim, Tae Yeob; Ahn, Byung Min

doi:10.3748/wjg.v19.i47.9069

Cited by 20 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…idiosyncratic DILI the analysis of the impact of the disease in terms of the QOL of patients 814 remains a neglected area of research. In a study conducted in South Korea in patients suffering 815 from a DILI episode, the authors found greater indexes of anxiety and depression in patients 816 with liver injury induced by herb and dietary supplements compared with healthy population 817 and patients with liver disease from other etiologies 174 . Interestingly, the DILIN group 818…”

mentioning

confidence: 97%

Drug-induced liver injury

Andrade

Chalasani

Bjõrnsson

et al. 2019

Nat Rev Dis Primers

534

338

View full text Add to dashboard Cite

Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when the subject is exposed to toxic doses of some compounds (acetaminophen overdose) or in an unpredictable way with many drugs in common use. Drugs can be harmful to the liver in a susceptible subject on the background of genetic and environmental factors. This accounts for modifications in the hepatic metabolism and excretion of the agent leading to cellular stress, direct cell death, activation of an adaptive immune response and a failure to adapt with progression to overt liver injury. Idiosyncratic DILI is a relative rare liver disorder but can be severe and even fatal, presenting with a variety of phenotypes, which mimic almost every other liver disease. Diagnosis of DILI relies on the exclusion of other etiologies of liver disease as specific biomarkers are still lacking. Clinical scales such as CIOMS/RUCAM can support the diagnostic process but need a refinement. A number of clinical variables, validated in prospective cohorts, can be used to predict a more severe DILI outcome. Although no pharmacological therapy has yet been adequately tested in randomized clinical trials, corticosteroids can be useful, particularly in the emergent form of DILI related to immune checkpoint inhibitors.

show abstract

mentioning

confidence: 97%

Drug-induced liver injury

Andrade

Chalasani

Bjõrnsson

et al. 2019

Nat Rev Dis Primers

534

338

View full text Add to dashboard Cite

show abstract

“…It plays diverse biological roles and impacts other systems of the body. Patients afflicted with chronic liver disease 8 , acute toxic hepatic injury 9 , non alcoholic fatty liver 10 and liver cirrhosis 11 manifest different degrees of depression and anxiety. However, no studies are available correlating central nervous system mental illnesses such as depression with hepatic pathology, though Traditional Chinese Medicine relates the harmful effects of rage on liver function 12 .…”

mentioning

confidence: 99%

Chronic unpredictive mild stress leads to altered hepatic metabolic profile and gene expression

Jia

Zhou

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Depression is a complex disease characterized by a series of pathological changes. Research on depression is mainly focused on the changes in brain, but not on liver. Therefore, we initially explored the metabolic profiles of hepatic extracts from rats treated with chronic unpredictive mild stress (CUMS) by UPLC-Q-TOF/MS. Using multivariate statistical analysis, a total of 26 altered metabolites distinguishing CUMS-induced depression from normal control were identified. Using two-stage receiver operating characteristic (ROC) analysis, 18 metabolites were recognized as potential biomarkers related to CUMS-induced depression via 12 metabolic pathways. Subsequently, we detected the mRNA expressions levels of apoptosis-associated genes such as Bax and Bcl-2 and four key enzymes including Pla2g15, Pnpla6, Baat and Gad1 involved in phospholipid and primary bile acid biosynthesis in liver tissues of CUMS rats by real-time qRT-PCR assay. The expression levels of Bax, Bcl-2, Pla2g15, Pnpla6 and Gad1 mRNA were 1.43,1.68, 1.74, 1.67 and 1.42-fold higher, and those of Baat, Bax/Bcl-2 ratio mRNA were 0.83, 0.85-fold lower in CUMS rats compared with normal control. Results of liver-targeted metabonomics and mRNA expression demonstrated that CUMS-induced depression leads to variations in hepatic metabolic profile and gene expression, and ultimately results in liver injury.

show abstract

“…Interestingly, Suh et al [41] showed that psychological factors that present vulnerability to the temptation to use alternative medicines such as herbs and plant preparations are important for understanding toxic liver injury. Therefore, the treatment of toxic liver injury itself is important.…”

Section: Herbal and Dietary Supplement Hepatotoxicitymentioning

confidence: 99%

Drug-induced liver injury

Suh

2020

Yeungnam Univ J Med

Self Cite

View full text Add to dashboard Cite

Drug-induced liver injury (DILI), including herbal and dietary supplement hepatotoxicity, is often passed lightly; however, it can lead to the requirement of a liver transplant or may even cause death because of liver failure. Recently, the American College of Gastroenterology, Chinese Society of Hepatology and European Association for the Study of the Liver guidelines for the diagnosis and treatment of DILI have been established, and they will be helpful for guiding clinical treatment decisions. Roussel Uclaf Causality Assessment Method scoring is the most commonly used method to diagnose DILI; however, it has some limitations, such as poor validity and reproducibility. Recently, studies on new biomarkers have been actively carried out, which will help diagnose DILI and predict the prognosis of DILI. It is expected that the development of new therapies such as autophagy inducers and various other technologies of the fourth industrial revolution will be applicable to DILI research.

show abstract

Anxiety and depression propensities in patients with acute toxic liver injury

Abstract: Psychological factors that present vulnerability to the temptation to use alternative medicines, such as herbs and plant preparations, are important for understanding toxic liver injury.

Cited by 20 publications

References 27 publications

Drug-induced liver injury

Drug-induced liver injury

Chronic unpredictive mild stress leads to altered hepatic metabolic profile and gene expression

Drug-induced liver injury

Contact Info

Product

Resources

About