Aortic and coronary calcifications in Takayasu arteritis

Seyahi, Emire; Ucgul, Ayca; Olgun, Deniz Çebi; Uğurlu, Serdal; Akman, Canan; Tutar, Onur; Yurdakul, Sebahattin; Yazıcı, Hasan

doi:10.1016/j.semarthrit.2012.11.001

Cited by 38 publications

(33 citation statements)

References 49 publications

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“…15 Seyahi et al 53 evaluated the presence of TAC in 47 patients with TA, 43 patients with SLE, and 70 healthy control subjects using multidetector CT. TAC was present in 21 patients with TA (45%). In 8 patients, it was diffuse and extended from the ascending to the descending aorta.…”

Section: Systemic Inflammatory Diseasesmentioning

confidence: 99%

Porcelain Aorta

et al. 2015

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Section: Systemic Inflammatory Diseasesmentioning

confidence: 99%

Porcelain Aorta

et al. 2015

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“…A high rate of atherosclerotic plaques was shown previously with Carotid US in TAK [62]. Recently, Seyahi et al combined US with multi-detector CT and detected a high prevalence of thoracic aorta calcifications [63]. Carotid contrast-enhanced US is also suggested as a better method for the visualization of the carotid lumen border, and may allow a dynamic assessment of carotid wall vascularization and intima-media thickening [64,65].…”

Section: Imaging In Takmentioning

confidence: 90%

Update on Takayasu's arteritis

Alıbaz-Öner

Direşkeneli

2015

La Presse Médicale

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“…Coronary wall in ammation can lead to myocardial ischemia, which further accelerates early coronary atherosclerosis. Secondary myocardial ischemia caused by stenosis and occlusion of coronary arteries is also a signi cant cause for death of TAK [20].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for the adverse cardiac outcomes in the patients with Takayasu’s arteritis.

Wang

Yan

et al. 2020

Preprint

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Background : This study was aimed to investigate the long-term cardiac outcomes and find out risk factors for the deterioration of cardiac structure and function in patients with Takayasu’s arteritis (TAK).Methods : One hundred and ninety-eight TAK patients were recruited in the Department of Rheumatology, Zhongshan Hospital, Fudan University from January 2012 to December 2017. The endpoint of observation was December 31, 2019. Patients were divided into normal, mild-moderate and severe subgroups based on the severity of structural and functional impairment of heart. Comparison of baseline characteristics and treatment among these three subgroups was conducted to identify the risk factors for adverse cardiac outcomes.Results : A total of 60.1% (119/198) of TAK patients exhibited heart involvement on echocardiography at baseline. 70.6% (84/119) and 79.8% (95/119) cases showed pathological valvular and atrioventricular abnormalities, respectively. 68.7% (136/198) of patients were followed up and the median follow-up duration was 28.6 (12.3-43.4) months. 42.7% (58/136) and 22.8% (31/136) of patients had progress in heart’s structure and function. Cox regression showed that serum TNF-α level (HR=1.028, p= 0.021), aortic regurgitation (HR=3.109, p<0.001) and ventricular hypertrophy (HR=2.090, p= 0.006) at baseline were risk factors for the deterioration of cardiac structure. The cases with serum TNF-α levels (≥8.1pg/ml), mild aortic regurgitation and ventricular hypertrophy at baseline had highest risk of structural progression at 83.4%. Using normal subgroup as a control, the deterioration of cardiac structure and function was the most severe in the severe subgroup, with hazard ratios of 16.2 (95% CI, 6.0-44.1, p < 0.001) and 9.0 (95% CI, 3.3-24.5, p<0.001), respectively. The deteriorating events typically occurred within 2 years after diagnosis.Conclusions : To find out if there is heart involvement and progress, it’s indispensable to regularly monitor the serum TNF-α level and cardiac structure in TAK patients during the long-term follow-up.

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Aortic and coronary calcifications in Takayasu arteritis

Cited by 38 publications

References 49 publications

Porcelain Aorta

Porcelain Aorta

Update on Takayasu's arteritis

Risk factors for the adverse cardiac outcomes in the patients with Takayasu’s arteritis.

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