Aortic and Iliac Involvement in Brucellosis – A Rare but Life Threatening Manifestation: A Review of the Literature

Willems, Siem A.; Brouwers, Jeroen J.W.M.; Eefting, D.

doi:10.1016/j.ejvs.2022.02.004

Cited by 15 publications

(21 citation statements)

References 60 publications

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“…In a review published in 2022, Siem et al reported that aortoiliac artery disease involving brucellosis is an underdiagnosed and underreported disease. [ 9 ] Brucellosis involving large arteries has occult and nonspecific manifestations and requires high suspicion. Any acute chest or abdominal pain should be suspected of aortic involvement, and a routine aortic examination should be performed to confirm aortic involvement.…”

Section: Discussionmentioning

confidence: 99%

Human descending aorta injury caused by brucellosis: A case report

Sun

Zhang

et al. 2023

Medicine

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Background: Brucellosis is one of the most common zoonotic diseases in the world. Although cardiovascular complications of human brucellosis account for only 3% of morbidity, they are the leading cause of death. Peripheral vascular disease due to brucellosis is rare and under-reported in the literature. Case presentation: Two patients with previous brucellosis, both of whom had been treated with anti-brucellosis, were admitted to vascular surgery for thoracic aortic ulcer and abdominal aortic pseudoaneurysm, respectively, with positive IgG antibody to brucellosis and negative IgM antibody to brucellosis, tube agglutination test, and blood culture. These 2 patients were successfully treated with aortic stent-graft implantation and followed up for 8 and 10 weeks without complications. Conclusions: Chronic damage to human blood vessels by brucellosis may not disappear with brucellosis treatment, and peripheral blood vessels should be examined annually in people previously diagnosed with brucellosis. Clinicians in related departments should pay attention to peripheral vascular complications of brucellosis.

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Section: Discussionmentioning

confidence: 99%

Human descending aorta injury caused by brucellosis: A case report

Sun

Zhang

et al. 2023

Medicine

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“… 3 Infected aortic aneurysm (IAAA) is much rarer in brucellosis, 4 and the risk of death from arterial dissection is extremely high, with 71 cases identified in the last 70 years and a global mortality rate of 22%. 5 Open surgery and long-term antibiotics are usually required to complete treatment and monitor postoperative complications such as graft infection, recurrent (pseudo) aneurysms, and abscess formation. 6 The early symptoms of this disease are similar to those of many other diseases and lack specificity, especially in noninfected areas where the disease is disseminated.…”

Section: Introductionmentioning

confidence: 99%

Brucella Infectious Aneurysm: A Retrospective Study of 14 Cases and Review of the Literature – Case Report and Literature Review

Wang¹,

Wang²,

Ma³

et al. 2023

IDR

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Objective To analyze the clinical characteristics and treatment process of 14 patients with aneurysm due to brucellosis, summarize the morbidity characteristics, and improve the knowledge and diagnosis of the disease. Methods The clinical data of patients with aneurysms who were diagnosed to have brucellosis through Rose Bengal Test (RBT), Serum Agglutination Test (SAT), blood culture, and computed tomography angiography from January 2012 to November 2022 in Bethune Hospital, Shanxi Province, China, were retrospectively analyzed, and their clinical characteristics and disease regression findings were summarized. Results Of the 14 patients, 13 were men, and 1 was a woman; the youngest patient was 48-year-old, and the oldest patient was of 74 years. All had a history of smoking. The sites of lesion occurrence included the abdominal aorta (5 patients), abdominal aorta +iliac artery (5 patients), iliac artery (2 patients), thoracic aorta and brachial artery were less common (1 case each). Symptoms in the patients mostly began with abdominal pain, which was accompanied by fever, nausea, and vomiting. Six patients had a clear history of livestock exposure. Fourteen patients showed elevated D-dimer and C-reactive protein levels and decreased hemoglobin and albumin levels. Thirteen of the 14 cases were treated surgically, there were no complications of surgery, and 3 patients were readmitted with recurrence of brucellosis, it is related to the treatment that did not reach the early stage, combination, full dose and full course of treatment, with a mean recurrence time of 8 months. In the telephone follow-up, the patient’s recovery proceeded well. Conclusion The present study revealed that the recurrence in male gender, advanced age, smoking and irregular treatment is higher. On the contrast, early intervention, a combination of adequate course of anti-infection treatment and timely surgery can improve the prognosis.

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“…The incidence of brucellosis is increasing yearly due to the successful development of animal husbandry in China, which increases the chance of human infection ( Jiang et al, 2020 ). Brucellosis has a wide range of clinical manifestations, ranging from acute indistinguishable febrile illness to chronic infectious disease that most often affects the central nervous, cardiovascular, or skeletal systems ( Willems et al, 2022 ). Although cardiovascular involvement in brucellosis is rare, complications due to cardiovascular involvement are a common cause of death from brucellosis.…”

Section: Introductionmentioning

confidence: 99%

“…We had a 6-month follow-up, and the patient was healthy and asymptomatic. A recently published review showed that in the peripheral vasculature, brucellosis most frequently affects the abdominal and thoracic aorta, with iliac and other peripheral arteries more rarely involved ( Willems et al, 2022 ). Here, we report four cases of abdominal aortic pseudoaneurysm caused by brucellosis: one patient was previously diagnosed with brucellosis before admission, the other three patients were diagnosed at examination after abdominal aortic pseudoaneurysm was detected, and all four patients were treated with an EVAR technique.…”

Section: Introductionmentioning

confidence: 99%

Treatment of abdominal aortic pseudoaneurysm caused by brucellosis with endovascular aneurysm repair

Wang²,

Zhang³

et al. 2023

Front. Bioeng. Biotechnol.

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Peripheral vascular disease caused by brucellosis is rarely seen around the world; thus, it is easily ignored by patients and doctors, leading to a lack of corresponding screening and delayed comprehensive treatment. Currently, there is no standard or guideline for diagnosing and treating peripheral arterial disease caused by brucellosis. From June 2021 to December 2022, four cases of abdominal aortic pseudoaneurysm caused by brucellosis disease were treated with endovascular aneurysm repair This study reported treatment results as follows and reviewed the incidence, treatment, and prognosis of abdominal aortic pseudoaneurysm caused by brucellosis.

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Aortic and Iliac Involvement in Brucellosis – A Rare but Life Threatening Manifestation: A Review of the Literature

Cited by 15 publications

References 60 publications

Human descending aorta injury caused by brucellosis: A case report

Human descending aorta injury caused by brucellosis: A case report

Brucella Infectious Aneurysm: A Retrospective Study of 14 Cases and Review of the Literature – Case Report and Literature Review

Treatment of abdominal aortic pseudoaneurysm caused by brucellosis with endovascular aneurysm repair

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