Aortic arch thrombosis in the neonate

Conti, Vincent R.; Bilfinger, Thomas V.; Wolf, Wendy J.

doi:10.1016/s0022-5223(19)35398-x

Cited by 15 publications

(11 citation statements)

References 9 publications

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“…Homocystinuria and hypercoagulable states, such as protein C deficiency, have also been associated with thrombosis of major vessels. 4 These conditions were all ruled out in the cases reported.…”

Section: Discussionmentioning

confidence: 98%

Idiopathic Cerebral Infarction and Upper Limb Ischemia in Neonates

Guajardo

Strauss²,

Amster³

1994

Amer J Perinatol

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Section: Discussionmentioning

confidence: 98%

Idiopathic Cerebral Infarction and Upper Limb Ischemia in Neonates

Guajardo

Strauss²,

Amster³

1994

Amer J Perinatol

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“…Medline search of English literature over the last 20 years detected only 12 cases, similar to the one we have described (see the table). [7][8][9][10][11][12][13][14][15][16][17] This clinical entity usually manifests within the first hours to days of life with severe heart failure and symptoms mimicking coarctation or interruption of the aorta. Other more frequently suggested diagnoses include cyanotic congenital heart disease and hypoplastic left heart.…”

Section: Discussionmentioning

confidence: 99%

“…11,16 Both surgery and thrombolysis have been advocated as possible primary treatment options. 9,[13][14][15]28 Surgery offers the advantage of immediate relief of the life-threatening obstruction and has been successfully used in the treatment of organized, partially calcified thrombi in the aortic arch, without the involvement of other major vessels. [13][14][15] Rethrombosis may occur, necessitating postoperative anticoagulation.…”

Section: Discussionmentioning

confidence: 99%

“…9,[13][14][15]28 Surgery offers the advantage of immediate relief of the life-threatening obstruction and has been successfully used in the treatment of organized, partially calcified thrombi in the aortic arch, without the involvement of other major vessels. [13][14][15] Rethrombosis may occur, necessitating postoperative anticoagulation. 9 The feasibility of surgical treatment in thrombosis, starting proximal to the origin of the innominate artery, has been questioned.…”

Section: Discussionmentioning

confidence: 99%

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Aortic Arch Thrombosis in a Neonate With Heterozygous Carrier Status of Factor V Leiden Mutation

Metsvaht

Hermlin

Kern

et al. 2006

Congenital Heart Disease

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Neonatal spontaneous aortic arch thrombosis without an anatomical correlate is an extremely rare disorder of unknown etiology. A 1-day-old newborn was admitted with suspicion of the coarctation of the aorta. Angiography revealed congenital occluding thrombosis of the ascending aorta and the aortic arch. Surgery was considered impossible because of concomitant thrombosis of the inferior vena cava and the right renal vein. Thrombolysis with streptokinase and tissue plasminogen activator was attempted unsuccessfully. Heterozygous carrier status of the factor V Leiden mutation was diagnosed as a single prothrombotic risk factor. Congenital prothrombotic conditions including factor V Leiden carrier status may serve as risk factors for the development of spontaneous aortic arch thrombosis in neonates. In chronic organized thrombi thrombolytic therapy is likely to fail.

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“…Die Folgen dieser Komplikation können schwerwiegend sein; es wurde über Störungen des Wachstums und der motorischen Entwicklung der unteren Extremitäten, das Auftreten einer renalen Hypertonie, eines Nierenversagens, einer nekrotisierenden Enterokolitis sowie sogar tödlichen Ausgang berichtet (4,10,14,21). Ein spontaner Verschluß der Aorta -häufiger abdominal als thorakal (6) -wurde verschiedentlich in Einzelbeschreibungen erwähnt; zumeist bleibt die Ursache ungeklärt (2,6,12).…”

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Thrombotischer Verschluß der Aorta abdominalis im Neugeborenenalter - erfolgreiche Lysebehandlung

et al. 1992

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Aortic thrombosis during neonatal period is rare and usually related to an umbilical artery catheter. In an infant (birth weight 3110 gm) with complete thrombosis of the abdominal aorta distal to the renal arteries of unknown etiology we started a fibrinolytic therapy with streptokinase at the age of 12 days (streptokinase intravenously with an initial loading dose of 3000 U/kg, maintenance 1000 U/kg/hr for 2 days). This was followed by a heparinisation (10,000 U/m2/d, 24 hours later 200 U/kg/d). 72 hours after onset of therapy there was no blood pressure difference between upper and lower limbs. Side-effects of therapy did not occur; the success of medical treatment continued after termination of the heparinisation.

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Aortic arch thrombosis in the neonate

Cited by 15 publications

References 9 publications

Idiopathic Cerebral Infarction and Upper Limb Ischemia in Neonates

Idiopathic Cerebral Infarction and Upper Limb Ischemia in Neonates

Aortic Arch Thrombosis in a Neonate With Heterozygous Carrier Status of Factor V Leiden Mutation

Thrombotischer Verschluß der Aorta abdominalis im Neugeborenenalter - erfolgreiche Lysebehandlung

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