Aortic Intima Media Thickness is an Early Marker of Atherosclerosis in Children with Type 1 Diabetes Mellitus

Harrington, Jennifer; Peña, Alexia S; Gent, Roger; Hirte, Craig; Couper, Jennifer

doi:10.1016/j.jpeds.2009.08.036

Cited by 109 publications

(144 citation statements)

References 21 publications

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“…STZ injection significantly increased thickness of tunica media in this study. In human studies tunica media thickness of aorta increased significantly in diabetes compared with the healthy people (25)(26)(27).…”

Section: Discussionmentioning

confidence: 92%

Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of α-SMA expression

Elbe¹,

Vardı²,

Orman³

et al. 2014

Anadolu Kardiyol Derg

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Objective: Diabetes mellitus is one of the chronic metabolic diseases which is characterized by microvascular and macrovascular complications. This study was designed to investigate the improving the effects of amnioguanidine on aortic damage in a streptozotocin (STZ) induced diabetic rat model. Methods: Thirty-two male Sprague-Dawley rats divided into four groups as follows: Control, Aminoguanidine, Diabetes, and Diabetes+Aminoguanidine. Experimental diabetes was induced by single dose STZ (45 mg/kg) intraperitoneally. After administration of STZ, the DM+AMG group began to receive AMG (1 g/L) was prepared by dissolving in tap water during 10 weeks. At the end of the study, blood glucose levels were determined and rats were sacrified by ketamine anesthesia. Following routine tissue process, aortas were embedded in paraffin. Histochemical (H-E and Orcein) and immunohistochemical α-smooth muscle actin (α-SMA) stains were applied and the sections examined by light microscope. Statistical analysis was carried out using the SPSS 13.0 statistical program. Results: The rats in diabetes group had significantly higher blood glucose levels than the rats of control. The main histological alterations were detected in tunica media such as extensive thickening (414.32±9.62 μm), irregular of elastic fibers and intensive α-SMA staining in diabetic rats. The thickness of tunica media was statistically increased in DM group, when compared with the control group (p<0.001). On the other hand, AMG prevented disorganization of elastic fibers and overexpression of α-SMA. The mean thickness of tunica media was decreased significantly in DM+AMG (319.16±6.53 μm) compared with the DM group (p<0.001).Conclusion: Our results demonstrate that AMG treatment may protect the impairment of aort structure at histological level.

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Section: Discussionmentioning

confidence: 92%

Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of α-SMA expression

Elbe¹,

Vardı²,

Orman³

et al. 2014

Anadolu Kardiyol Derg

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“…The metabolic disorders resulting from chronic hyperglycaemia leading to atherosclerosis and increased arterial stiffness are also involved in the development of hypertension in diabetic patients [106][107][108][109]. Although, renal failure in diabetic kidney disease usually occurs after many years of disease, the early stages of diabetic kidney disease characterized by increased albuminuria are observed also in the paediatric population [110][111][112][113]. In adolescents kidney damage in T1DM is directly related to elevated BP values, and effective antihypertensive treatment slows the progression of kidney damage [114].…”

Section: Pathogenesis Of Hypertension In Children With Diabetesmentioning

confidence: 99%

Zalecenia Sekcji Pediatrycznej Polskiego Towarzystwa Nadciśnienia Tętniczego dotyczące postępowania diagnostycznego i terapeutycznego w nadciśnieniu tętniczym u dzieci i młodzieży

Litwin

Niemirska

Obrycki

et al. 2018

Arterial Hypertension

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Presented recommendations are an extended and actualized version of paediatric recommendations of Polish Society of Hypertension published in 2015. Since then, new studies have appeared on this subject, introducing a new classification of hypertension, newly described principles of management in risk groups and methods of assessing hypertensive target organ damage. The presented updated recommendations included changes introduced in the 2016 European Society of Hypertension recommendations and Recommendations of Children's Memorial Health Institute in Warsaw. Recently published guidelines of American Academy of Pediatrics have been discussed. In the presented issue of guidelines, epidemiological information on the occurrence and incidence of hypertension in developmental age was added and classification of blood pressure values was updated. Subchapters on diagnosis and organ damage assessment, principles of diagnosis and treatment of hypertension in children with diabetes, chronic kidney disease and a subsection discussing diagnostic and therapeutic difficulties with setting blood pressure targets were revised. In addition, the principles of early diagnosis of arterial hypertension in post-hospital care in children born before 33 weeks of gestation published in 2018 as recommendations of the Polish Neonatal Society have been also taken into account.

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“…In addition, the increased thickness of the tunica media may be partly due to the increased medial smooth muscle cells observed in the hyperthyroid group. It was reported that aortic intima-media thickness was an earlier marker of preclinical atherosclerosis [11], which had been observed in the hyperthyroid group.…”

Section: Discussionmentioning

confidence: 88%

Thyroid hormone dysfunctions affect the structure of rat thoracic aorta: a histological and morphometric study

Zaki

Youssef

2013

Folia Morphol

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Aortic Intima Media Thickness is an Early Marker of Atherosclerosis in Children with Type 1 Diabetes Mellitus

Cited by 109 publications

References 21 publications

Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of α-SMA expression

Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of α-SMA expression

Zalecenia Sekcji Pediatrycznej Polskiego Towarzystwa Nadciśnienia Tętniczego dotyczące postępowania diagnostycznego i terapeutycznego w nadciśnieniu tętniczym u dzieci i młodzieży

Thyroid hormone dysfunctions affect the structure of rat thoracic aorta: a histological and morphometric study

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