Aortic Stiffness and Disease

Chowienczyk, Phil

doi:10.1161/circulationaha.115.016377

Cited by 6 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stiffening processes may not uniformly affect the arterial tree 41 and segmental arterial stiffening may be critical for arterial pathologies, such as AAA formation; 42 therefore, local assessment of arterial stiffness is desirable. This can be achieved by quantification of the fractional change in arterial diameter produced by cyclic systolic-diastolic pressure change.…”

Section: Physiological Arterial Compliance and Assessment Of Arterialmentioning

confidence: 99%

Killing Me Unsoftly

Lyle

Raaz

2017

ATVB

113

View full text Add to dashboard Cite

The aorta is a blood vessel that provides a low resistance path for blood flow directed from the heart to peripheral organs and tissues. However, the aorta has another central hemodynamic function whereby the elastic nature of the aortic wall provides a significant biomechanical buffering capacity complementing the pulsatile cardiac blood flow and this is often referred to as Windkessel function. Stiffening of the arterial wall leads to fundamental alterations in central hemodynamics with widespread detrimental implications for organ function. In this review article, we aim to provide a short general overview of some of the most common mechanisms that contribute to increased arterial stiffness, the consequences of arterial stiffening, and the clinical conditions in which arterial stiffness occurs with a focus on recent advancements in the field.

show abstract

Section: Physiological Arterial Compliance and Assessment Of Arterialmentioning

confidence: 99%

Killing Me Unsoftly

Lyle

Raaz

2017

ATVB

113

View full text Add to dashboard Cite

show abstract

“…Previous research on the development of an alternative aortic anastomotic device has been significant, but none of the suggested devices have been finally adopted in everyday clinical practice. Devices such as ringed grafts, stents, staplers, couplers, and adhesives [24][25][26][27][28][29][30][31][32][33] have been considered in an effort to improve aortic anastomosis, and their use under experimental conditions has been examined. Through an elaborate meta-analysis [14], our team assessed the efficacy of these experimental devices in comparison with hand sewn anastomosis for the outcomes of anastomosis time and point of anastomosis rupture.…”

Section: Discussionmentioning

confidence: 99%

“…A cantilever beam weighing scale force sensor was combined with an HX711-24-bit A/D and a microcontroller to measure the load applied on the PDMS when the needle was inserted into it with a resolution of 5 mg. The force sensor was placed on the backside of the PDMS In patients requiring aortic reconstruction, the aortic tissue is often stiff due to inflammatory aneurysmal tissue or extensive aortic calcification [28,29]. Therefore, a hardening step of the needle is imperative to increase the needle's durability when inserted multiple times into the aortic tissue during surgery.…”

mentioning

confidence: 99%

Precision Medicine in Aortic Anastomosis: A Numerical and Experimental Study of a Novel Double-Sided Needle

Manolesou

Korompili

Davazoglou

et al. 2021

JPM

View full text Add to dashboard Cite

Background: Hand-sewn anastomosis is a crucial part of aortic reconstruction surgery and significantly affects its outcome. The present study presents a novel, bidirectional surgical needle aimed to improve aortic anastomosis in terms of speed and ease of use. Our objective was to assess the efficacy of the new design in comparison with the conventional needle. Methods: A series of simulations were conducted with COMSOL software in order to perform a fatigue comparative analysis between the new and the conventional needle design. Ease of penetration into a piece of polydimethylsiloxane was evaluated. Lastly, the prototype was tested under in-vitro conditions in comparison with the conventional needle. Results: Based on fatigue analysis, the new needle design improves durability, provided the two tips are equally used. The polytetrafluoroethylene coating improves penetration into the tissue by 7% to 17%, while electropolishing improves penetration up to 19%. When using the novel needle design, the average anastomotic task completion time was significantly reduced by 22% and the overall distance of hand movements was significantly reduced by 20%. Conclusions: The proposed design exhibited a shorter anastomotic time and seems promising in relation to ease of use and simplicity of the anastomotic technique it introduces.

show abstract

“…[7] Reversing AC has been proposed as a potential therapeutic target for aortic diseases. [17, 18] Both coronary artery calcification (CAC) and aortic arch calcification (AAC) have been demonstrated to be predictors of future cardiovascular events. [19–22] Risk stratification by the presence of AAC provides important information for the management of atherosclerotic disease.…”

Section: Discussionmentioning

confidence: 99%

Association between acute aortic dissection and the distribution of aortic calcification

et al. 2019

View full text Add to dashboard Cite

Objective Aortic calcification (AC) is associated with increased risks of cardiovascular events and mortality. Numerous studies have explored the association between calcification and abdominal artery aneurysm. However, evidence regarding the association between AC and acute aortic dissection (AAD) is limited. We aimed to evaluate the association between AC-related variables and the development of intimal tear (IT) in patients with AAD. Methods We conducted a retrospective observational study involving 64 patients with type A AAD and 32 patients with type B AAD from February, 2011 to January, 2017 at a tertiary referral medical center in Taiwan. We used the default analysis module “calcification score analysis” to calculate all the calcification variables, including AC scores and volume. Results We identified an association between AC and AAD. Patients with AAD had a greater AC volume in the aortic arch and greater AC scores for both the ascending aorta and the aortic arch than did patients without AAD. However, hypertension and coronary artery disease, rather than AC remained to be the independent risk factor for AAD in multivariate analysis. Patients with type A AAD had greater mean and cumulative AC volumes in the aortic arch, greater cumulative AC volumes in the whole aorta and higher cumulative AC scores in the aortic arch than did patients with type B AAD. ACs were superimposed on ITs in nearly half of the patients with AAD. In patients with type A AAD, AC was more commonly located distal to the IT and farther from the IT. Conclusions We identified the associations between AC-related variables and the location of IT in patients with AAD. However, AC was not an independent risk factor for AAD. The distribution of AC was different between patients with type A and type B AAD.

show abstract

Aortic Stiffness and Disease

Cited by 6 publications

References 16 publications

Killing Me Unsoftly

Killing Me Unsoftly

Precision Medicine in Aortic Anastomosis: A Numerical and Experimental Study of a Novel Double-Sided Needle

Association between acute aortic dissection and the distribution of aortic calcification

Contact Info

Product

Resources

About