Aortic Valve Rheumatoid Nodules Producing Clinical Aortic Regurgitation and A Review of the Literature

Chand, Eric M.; Freant, Lawrence J.; Rubin, Joseph W.

doi:10.1016/s1054-8807(99)00024-1

Cited by 24 publications

(14 citation statements)

References 13 publications

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“…Although cardiac involvement of RA is high in autopsy case studies (often reported 30% range), clinical manifestations are uncommon (<3% of cases), most frequently pericarditis. 31,32 As with pulmonary lesions, the histopathology of cardiac nodules mimics the description of subcutaneous nodules. It is defined by a central zone of necrosis, surrounded by palisading histiocytes, and an outer layer of inflammatory infiltrate.…”

Section: Systemic Location Of Rheumatoid Nodulesmentioning

confidence: 99%

“…It is defined by a central zone of necrosis, surrounded by palisading histiocytes, and an outer layer of inflammatory infiltrate. 32 A study of 37 patients suggests that valvular nodules occur in the following order: mitral 57%, aortic 48%, tricuspid 13%, and pulmonic 11%. 32 Another series of 22 patients with aortic valve lesions found that two-thirds of these patients had concomitant mitral valve nodular involvement and both were associated with subcutaneous nodules (75%).…”

Section: Systemic Location Of Rheumatoid Nodulesmentioning

confidence: 99%

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Rheumatoid Nodules

Tilstra

Lienesch

2015

Dermatologic Clinics

102

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Rheumatoid nodules are a common manifestation of rheumatoid arthritis. These lesions are often easily identified based on typical diagnostic features and characteristic locations. When biopsied, nodules have a characteristic histologic appearance. Uncommonly, rheumatoid nodules can occur in systemic locations. There is no evidence that systemic therapy treats underlying rheumatoid nodules. Paradoxically, methotrexate and possibly tumor necrosis factor inhibitors can increase nodule development. Treatment of rheumatoid nodules is often not necessary, unless patients are experiencing pain or there is interference of mechanical function. This review outlines the available data on and associations of rheumatoid nodules.

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Section: Systemic Location Of Rheumatoid Nodulesmentioning

confidence: 99%

Section: Systemic Location Of Rheumatoid Nodulesmentioning

confidence: 99%

Rheumatoid Nodules

Tilstra

Lienesch

2015

Dermatologic Clinics

102

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“…Rheumatoid valve affection by rheumatoid nodules is characterised by fibrinoid necrosis surrounded by epithelioid histiocytes and lymphocytes 21. The basis for this process is an immunological disorder involving inflammation.…”

Section: Discussionmentioning

confidence: 99%

Effect of high-intensity statin treatment in rheumatoid arthritis: a case with possible coronary atheroma regression and progression of rheumatoid valve degeneration

Semb

Provan²,

Kvien³

et al. 2009

Case Reports

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Rheumatoid arthritis (RA) is complicated by high mortality from cardiovascular disease. Statins have been shown to reduce cardiovascular disease events by approximately 30% and to induce coronary atheroma regression. There is no such documentation in patients with RA. This report describes a 49-year-old patient with RA who developed coronary atherosclerosis and rheumatoid valve disease. She underwent coronary artery bypass graft operation with two bypasses and a biological aortic valve replacement. Simultaneously, she was started on atorvastatin 80 mg, and low-density lipoprotein cholesterol reached 1.79 mmol/l and high-density lipoprotein cholesterol reached 1.59 mmol/l. One year after the heart surgery, she developed rheumatoid disease of the mitral valve. Coronary angiography revealed no signs of filling defect in her native coronary arteries. This case indicates that high-dose statin treatment may induce coronary atheroma regression in RA patients and that the rheumatoid valve disease process is not modulated by statins.

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“…Cardiac involvement is common and occurs in up to 50% of the affected patients. 5 Guedes et al 6 showed an increased incidence of mitral, aortic, and tricuspid valve dysfunction, involving up to 83% of RA patients. RA valve disease is almost always mild and asymptomatic, and is less likely than SLE to result in clinically significant valve dysfunction.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Cardiac Valve Involvement in Systemic Diseases: A Review

Grimaldi

Vermi

Pappalardo

et al. 2013

Clinical Cardiology

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Increasing age and new trends of mixed populations have newly aroused interest in valvular heart disease in the developed countries still in need of new clinical insights. In the clinical setting of systemic diseases, the proper assessment of cardiovascular abnormalities may be challenging, and the characterization of valvular involvement might help to recognize the underlying disease and cardiac sequelae. Prompt identification of valvular lesions may, therefore, also be useful for differential diagnosis. This article reviews the cardiac involvement in systemic diseases from etiology and background definition to echocardiographic assessment and clinical interpretation.The authors have no funding, financial relationships, or conflicts of interest to disclose.

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Aortic Valve Rheumatoid Nodules Producing Clinical Aortic Regurgitation and A Review of the Literature

Cited by 24 publications

References 13 publications

Rheumatoid Nodules

Rheumatoid Nodules

Effect of high-intensity statin treatment in rheumatoid arthritis: a case with possible coronary atheroma regression and progression of rheumatoid valve degeneration

Cardiac Valve Involvement in Systemic Diseases: A Review

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