Aortic wall inflammation: a more accurate predictor of aneurysm expansion and aneurysm rupture risk than aortic diameter?

Paraskevas, Kosmas I.

doi:10.21037/jtd.2018.09.36

Cited by 1 publication

(2 citation statements)

References 7 publications

(5 reference statements)

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“…Oxidative stress has been suggested to play a key role in the pathogenesis of AAA [ 20 , 21 ]. In our study Cu/Zn ratio was significantly higher only in AAA patients in comparison with the control group which indicates a greater role of oxidative stress thusly indicating inflammatory process in this type of aneurysm, than in TAA.…”

Section: Discussionmentioning

confidence: 57%

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Estimation of Selected Minerals in Aortic Aneurysms—Impaired Ratio of Zinc to Lead May Predispose?

Socha

Karwowska

Kurianiuk

et al. 2020

Biol Trace Elem Res

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The objective of this study was to estimate the content of copper, zinc, selenium, cadmium, and lead in the tissue of patients with aortic aneurysms. Molar ratio of Cu/Zn and antioxidant micronutrients to toxic elements was also calculated. A total of 108 patients: 47 with abdominal aortic aneurysm (AAA), 61 patients with thoracic aortic aneurysm (TAA), and a control group of 20 abdominal aortic (AA) and 20 thoracic aortic (TA) wall samples from the deceased were studied. The concentrations of mineral components in the tissue samples were determined by the AAS method. The average concentration of Cu in the aortic wall of patients with TAA was significantly lower than in the aortic wall samples of healthy people. The mean concentration of Zn in the aortic wall of patients with AAA and TAA was significantly lower than in the control group samples. Cu/Zn ratio was significantly higher in AAA patients than in control group which indicates a greater role of oxidative stress and inflammatory process in this type of aneurysm. The concentration of Se was significantly decreased in TAA patients compared with the control group; in turn, the concentration of Pb was increased in this group of patients. We observed significantly lower Cu/Pb ratio in TAA patients than in control group, whereas Zn/Pb ratio was significantly lower comparing with control samples in both types of aneurysms. In the examined aneurysms, we have shown the differences in concentrations of mineral components compared with the control tissues. The Zn concentration was decreased in both AAA and TAA samples. Impaired ratio of Zn to Pb may predispose to aortic aneurysms.

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Section: Discussionmentioning

confidence: 57%

“…Pb may induce oxidative stress and is considered as a potential immunotoxic factor [ 19 ]. Oxidative stress has been suggested to play a key role in the pathogenesis of AAA [ 20 , 21 ]. However, only few studies have been conducted to evaluate the oxidative stress status of AAA patients.…”

Section: Introductionmentioning

confidence: 99%

Estimation of Selected Minerals in Aortic Aneurysms—Impaired Ratio of Zinc to Lead May Predispose?

Socha

Karwowska

Kurianiuk

et al. 2020

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

Aortic wall inflammation: a more accurate predictor of aneurysm expansion and aneurysm rupture risk than aortic diameter?

Abstract: Paraskevas. Aortic wall inflammation and aneurysm rupture risk Cite this article as: Paraskevas KI. Aortic wall inflammation: a more accurate predictor of aneurysm expansion and aneurysm rupture risk than aortic diameter?

Cited by 1 publication

References 7 publications

Estimation of Selected Minerals in Aortic Aneurysms—Impaired Ratio of Zinc to Lead May Predispose?

Estimation of Selected Minerals in Aortic Aneurysms—Impaired Ratio of Zinc to Lead May Predispose?

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