Aorto-right ventricular fistula: a rare complication of Abiotrophia Endocarditis

Bhattacharya, Priyanka; Mohammed, Aasim; Mizrahi, Eddy

doi:10.1093/omcr/omx035

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…Since 2015, 17 cases (including our case) of A. defectiva en-docarditis have been reported in the English literature (Table 1) [1,4,[9][10][11][12][13][14][15][16][17][18][19][20][21], and these cases show a male predominance (11:6) and a mean age of 48.5±18.1 years. Approximately 2/3 had a pre-existing heart disease and of 15 with other medical conditions, eight had a history of some specific event like tooth extraction or pregnancy.…”

Section: Discussionmentioning

confidence: 97%

Bacterial Endocarditis Caused byAbiotrophia defectivain a Healthy Adult: A Case Report with Literature Review

Song

Chang

2019

Ann Clin Microbiol

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Infective endocarditis caused by Abiotrophia defectiva is rarely encountered. A 67-year-old male transferred from a local hospital presented with severe dyspnea and pulmonary edema. Preoperative transthoracic echocardiography revealed severe mitral regurgitation with large vegetation. Blood cultures grew A. defectiva, a gram positive, nutritionally deficient streptococcus variant. Emergent mitral valve replacement through right thoracotomy was performed, and after completing six weeks of antibiotic combination therapy (vancomycin, ampicillin, and gentamicin), the pa-tient recovered fully. Because of the need for prompt surgical treatment and long-term antibiotic therapy and lack of laboratory experience with the organism, physicians and laboratory workers should pay close attention to the possibility of A. defectiva infective endocarditis when gram positive cocci are detected in blood cultures.

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Section: Discussionmentioning

confidence: 97%

Bacterial Endocarditis Caused byAbiotrophia defectivain a Healthy Adult: A Case Report with Literature Review

Song

Chang

2019

Ann Clin Microbiol

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“…Compared to IE caused by other pathogens, A. defectiva -associated IE is more likely to form valvular vegetation and produce extracardiac organ embolic complications ( 21 , 22 ), with poor prognosis and high mortality. The most common complication of the heart in IE is the formation of valvular redundancy, with mitral valve involvement being the most common, followed by aortic valve, and in rare patients, aortic, tricuspid, and pulmonary valves ( 8 , 12 , 14 , 23 ), which can even be complicated by valve perforation in some cases ( 24 ). Extracardiac organ embolism can cause cerebral infarction, intracranial aneurysms, splenic infarction, infectious pneumonia, limb arterial embolism, aneurysms, etc.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Report of Infective Endocarditis Caused by Abiotrophia defectiva and Literature Review

Zhang

Chen

et al. 2022

Front. Pediatr.

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ObjectiveTo report the clinical features of the first child with infective endocarditis (IE) caused by Abiotrophia defectiva in mainland China and to raise awareness of the disease.MethodsThe clinical data of a child with IE caused by A. defectiva admitted to Xi’an Children’s Hospital in July 2021 were collected, and the relevant literature was reviewed.ResultsThe child was a female, 8 years old, admitted with fever for 4 days and right-sided limb weakness for 3 days. The illness started with suppurative tonsillitis, followed by headache, fatigue, right-sided mouth, slurred speech, right limb weakness, and unstable holding. Transthoracic echocardiography showed that the mitral valve vegetation was formed and vegetation could also be seen at the entrance of the pulmonary vein at the posterior wall of the left atrium. Cranial contrast-enhanced MRI + magnetic resonance angiography showed multiple intracranial pseudoaneurysm formation and pontine infarction. After A. defectiva was detected by metagenomic next-generation sequencing (mNGS) in cerebrospinal fluid and blood detected, the infection was controlled by anti-infective treatment with meropenem and vancomycin. On the 36th day after admission, due to severe headache and slurred speech, the head CT showed hemorrhage of right parietal pseudoaneurysm and cerebral sickle hernia, and right temporo-occipital hematoma evacuation, cerebrovascular malformation resection, and cranial decompression were performed immediately. After the surgery, her speech ability gradually recovered, the muscle strength of her left upper limb was about grade III, while the muscle strength of the rest of the limbs was normal. After a total of 60 days of hospitalization, her family requested to be discharged.ConclusionThis pediatric patient is the first case of childhood IE caused by A. defectiva in mainland China, and the first time in the world that A. defectiva was detected by mNGS in patients with IE.

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“…El aislamiento se envió a un centro especializado (Laboratorio de Bacteriología del Hospital de Clínicas José de San Martín de CABA) para confirmar el género y especie, resultando Abiotrophia defectiva mediante espectrometría de masas (MALDI-TOF) (7,10,11).…”

Section: Discussionunclassified

Primer caso de endocarditis por Abiotrophia defectiva en paciente adulto con coartación aórtica en hospital de Santa Fe

Valletto

Mollerach²,

Nagel³

et al. 2019

FABICIB

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Abiotrophia defectiva, previamente conocida como variante nutricional de estreptococos forma parte de la microbiota normal de la cavidad oral, urogenital y tracto gastrointestinal. Se asocia con infecciones severas como bacteriemia, endocarditis, abscesos cerebrales, osteomielitis, artritis séptica y queratopatía del cristalino. Es un microorganismo difícil de diagnosticar y las tasas de morbimortalidad, son altas.Se presenta el caso de un paciente adulto joven con coartación aórtica, con antecedentes de miocardio no compacto y comunicación ventricular pequeña, que consulta por cuadro de 16 días de evolución, caracterizado por dolor en la región glútea y fiebre.Se solicitan tres muestras de hemocultivos que se procesaron por método automatizado BACTEC (Phoenix). Las tres muestras de hemocultivos resultaron positivas a las 48 h para cocobacilos grampositivos en cadena. La identificación del aislamiento se realizó con autoanalizador BD PhoenixTM System dando como resultado Abiotrophia/Granulicatella, confirmándose por espectrometría de masas (MALDI-TOF) como Abiotrophia defectiva.Se realizó tratamiento antibiótico inicial con ampicilina, gentamicina y vancomicina por 7 días, continuando con ceftriaxona más gentamicina durante 22 días, evolucionando favorablemente.Debido a este hallazgo es importante alertar a los infectólogos y microbiólogos, considerar a Abiotrophia defectiva como posible agente causal de endocarditis.

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Aorto-right ventricular fistula: a rare complication of Abiotrophia Endocarditis

Cited by 6 publications

References 9 publications

Bacterial Endocarditis Caused byAbiotrophia defectivain a Healthy Adult: A Case Report with Literature Review

Bacterial Endocarditis Caused byAbiotrophia defectivain a Healthy Adult: A Case Report with Literature Review

Case Report: Report of Infective Endocarditis Caused by Abiotrophia defectiva and Literature Review

Primer caso de endocarditis por Abiotrophia defectiva en paciente adulto con coartación aórtica en hospital de Santa Fe

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