Apatite deposition on titanium surfaces — the role of albumin adsorption

Serro, Ana Paula; Fernandes, Anabela C.; Saramago, Benilde; Lima, J. J. G.; Barbosa, Mário A.

doi:10.1016/s0142-9612(97)00031-8

Cited by 106 publications

(87 citation statements)

References 19 publications

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“…Enhancement of the interface between the implants and cells has been attempted by creating open pores on the implant surface [38], making fiber metal composites [39], and treating the surface of the implants with calcium phosphates [40][41] by varying thermal conditions [42]. The interface was evaluated by cell adhesion, proliferation, and differentiation [35,43], as well as by cell morphology and cytoskeleton by scanning or confocal microscopy by synthesis of the proteins of the extracellular matrix and proteoglycans [36]. In vivo, the biocompatibility has been evaluated histologically [7,44].…”

Section: Discussionmentioning

confidence: 99%

Porous composite prosthetic pylon for integration with skin and bone

Pitkin¹,

Raykhtsaum²,

Pilling³

et al. 2007

JRRD

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Abstract-This article presents results of the further development and testing of the "skin and bone integrated pylon" (SBIP-1) for percutaneous (through skin) connection of the residual bone with an external limb prosthesis. We investigated a composite structure (called the SBIP-2) made of titanium particles and fine wires using mathematical modeling and mechanical testing. Results showed that the strength of the pylon was comparable with that of anatomical bone. In vitro and in vivo animal studies on 30 rats showed that the reinforcement of the composite pylon did not compromise its previously shown capacity for inviting skin and bone cell ingrowth through the device. These findings provide evidence for the safe and reliable long-term percutaneous transfer of vital and therapeutic substances, signals, and necessary forces and moments from a prosthetic device to the body.

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Section: Discussionmentioning

confidence: 99%

Porous composite prosthetic pylon for integration with skin and bone

Pitkin¹,

Raykhtsaum²,

Pilling³

et al. 2007

JRRD

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“…36 In this work, BSA was successfully codeposited in high concentration into a Ca-P coating on cpTi from an SCS containing BSA. The presence of BSA reduced the deposition rate of Ca-P coating to some extent, but led to the formation of a denser coating than that deposited from the blank SCS.…”

Section: Discussionmentioning

confidence: 99%

“…36 Scanning electron microscopy (SEM) equipped with energy-dispersive X-ray (EDX) analysis, X-ray diffraction (XRD), infrared (IR) spectrophotometry, and total organic carbon (TOC) measurement were employed to investigate microstructural features of the produced Ca-P and Ca-P/BSA coatings and release features of BSA from Ca-P/BSA coatings into neutral and acidic phosphate-buffered saline (PBS).…”

Section: Introductionmentioning

confidence: 99%

Incorporation of bovine serum albumin in calcium phosphate coating on titanium

Wen

Wijn

Blitterswijk

et al. 1999

J. Biomed. Mater. Res.

125

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Calcium phosphate (Ca-P) and bovine serum albumin (BSA) were coprecipitated as a coating on commercially pure titanium (cpTi) with a high protein loading (15 wt %) by employing a recently developed wet-chemistry technique. It was observed that the incorporation of BSA significantly modified the morphology, composition, and crystallinity of the Ca-P coating. The Ca-P coating without BSA is a mixture of hydroxyapatite (HA) and octacalcium phosphate (OCP) with sharp-edged thin OCP crystal plates on the top layer, whereas only an HA phase was detected in the Ca-P/BSA coating. The crystal plates in the latter had a more rounded appearance. The Ca-P/BSA coatings were immersed respectively in neutral (pH 7.4) and acidic (starting pH 4.0) phosphate-buffered saline (PBS) at 37 degrees C over a 14-day period. No protein release was detected in the neutral PBS during the immersion; however, a continuous release of BSA was measured in the acidic PBS, subsequently leading to the formation of a very dense and well-adherent composite coating of BSA and Ca-P on cpTi. The present study provides the possibility to achieve a long-term effective release of biologically active proteins from a Ca-P-coated metallic implant.

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“…Titanium readily adsorbs proteins from biological fluids. For instance, some specific proteins including albumin [43,44], laminin V [45], glycosaminoglycans [46], collagenase [47], fibronectin [48], complement proteins [49], and fibrinogen [50] have been found to adsorb onto titanium surface. Titanium surfaces can also support cell growth and differentiation.…”

Section: Biological Propertiesmentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,077

1,477

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Titanium and titanium alloys are widely used in biomedical devices and components, especially as hard tissue replacements as well as in cardiac and cardiovascular applications, because of their desirable properties, such as relatively low modulus, good fatigue strength, formability, machinability, corrosion resistance, and biocompatibility. However, titanium and its alloys cannot meet all of the clinical requirements. Therefore, in order to improve the biological, chemical, and mechanical properties, surface modification is often performed. This article reviews the various surface modification technologies pertaining to titanium and titanium alloys including mechanical treatment, thermal spraying, sol-gel, chemical and electrochemical treatment, and ion implantation from the perspective of biomedical engineering. Recent work has shown that the wear resistance, corrosion resistance, and biological properties of titanium and titanium alloys can be improved selectively using the appropriate surface treatment techniques while the desirable bulk attributes of the materials are retained. The proper surface treatment expands the use of titanium and titanium alloys in the biomedical fields. Some of the recent applications are also discussed in this paper. #

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Apatite deposition on titanium surfaces — the role of albumin adsorption

Cited by 106 publications

References 19 publications

Porous composite prosthetic pylon for integration with skin and bone

Porous composite prosthetic pylon for integration with skin and bone

Incorporation of bovine serum albumin in calcium phosphate coating on titanium

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

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