aPDT associated with sequestrectomy in the treatment of osteonecrosis in cancer patients with metastasis: Case report

A wide range of adjuvant treatments have been studied to treat osteonecrosis. Photobiomodulation and photodynamic therapy are commonly used. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic review was conducted to evaluate photobiomodulation and photodynamic therapy for the treatment of osteonecrosis related to the use of medications or related to ionising radiation. After searching PubMed, EMBASE, LILACS and Livivo Database, 2 systematic reviews, 4 prospective comparative studies, 10 comparative studies and 23 retrospective case reports were selected. Photobiomodulation-positive outcomes were observed in pain management and healing linked to osteonecrosis of the jaw due to antiresorptive drugs. Limited studies exist on photodynamic therapy and osteoradionecrosis. No adverse effects were reported. Despite the low quality of evidence, findings suggest that photobiomodulation may serve as an adjuvant therapy for osteoporotic patients, particularly those ineligible for surgery. Similar benefits were noted for oncological patients, but controlled trials evaluating cancer-related outcomes are lacking, emphasising the need for further research.

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Surgical and laser treatment for juvenile psammomatoid ossifying fibroma in an oncological patient: a rare case report

Pacheco

Tholt

Molena

et al. 2023

Bull Natl Res Cent

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Background Juvenile psammomatoid ossifying fibroma is a rare variant of conventional ossifying fibroma that affects the maxillofacial complex in children and adolescents. It is a benign fibro-osseous neoplasm with aggressive clinical behavior and high recurrence rates, confirming the importance of early diagnosis and intervention to minimize undesirable aesthetic and functional possibilities resulting from surgical management, and added to the use of laser therapy, it can bring a better postoperative prognosis. Aim To present the surgical removal of a juvenile psammomatoid ossifying fibroma, with the associated use of low-intensity laser and photodynamic therapy in a oncological patient. Case presentation This case describes a senile cancer patient diagnosed with rapidly progressive and painful juvenile ossifying fibroma involving the inter-radicular region of the right maxilla. The treatment was excision with total tumor resection, photodynamic therapy and low-intensity laser follow-up of 48 months. Conclusions Juvenile psammomatoid ossifying fibroma is a lesion with a high rate of recurrence and aggressive growth. Thus, early detection and treatment are essential. In this case, the use of photodynamic therapy after surgery and long-term follow-up with low-intensity laser brought a favorable prognosis in an oncology patient.

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aPDT associated with sequestrectomy in the treatment of osteonecrosis in cancer patients with metastasis: Case report

Cited by 4 publications

References 7 publications

Chlorhexidine/metronidazole/zoledronic acid

Chlorhexidine/metronidazole/zoledronic acid

Osteonecrosis: photobiomodulation and photodynamic therapy – a systematic review

Surgical and laser treatment for juvenile psammomatoid ossifying fibroma in an oncological patient: a rare case report

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