Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs

Ohno, Shino; Yakabi, Koji; Ro, Shoki; Ochiai, Mitsuko; Onouchi, Tsuneko; Sakurada, Tomoya; Takabayashi, Hidehiko; Ishida, Shinya; Takayama, Kiyoshige

doi:10.1016/j.regpep.2011.12.002

Cited by 22 publications

(19 citation statements)

References 22 publications

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“…In the gastrointestinal system, apelin/APJ may be regulators of hormone (Wang et al 2004) and gastric acid (Ohno et al 2012) secretion. Apelin/APJ may also have a direct effect on vascular smooth muscle, including vasoconstriction, which may affect renal glomerular hemodynamic function in the rat kidney (Hus-Citharel et al 2008).…”

Section: Other Functions Of the Apelinergic Systemmentioning

confidence: 99%

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

O’Carroll

Lolait

Harris

et al. 2013

Journal of Endocrinology

292

216

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The apelin receptor (APJ; gene symbol APLNR) is a member of the G protein-coupled receptor gene family. Neural gene expression patterns of APJ, and its cognate ligand apelin, in the brain implicate the apelinergic system in the regulation of a number of physiological processes. APJ and apelin are highly expressed in the hypothalamo-neurohypophysial system, which regulates fluid homeostasis, in the hypothalamic-pituitary-adrenal axis, which controls the neuroendocrine response to stress, and in the forebrain and lower brainstem regions, which are involved in cardiovascular function. Recently, apelin, synthesised and secreted by adipocytes, has been described as a beneficial adipokine related to obesity, and there is growing awareness of a potential role for apelin and APJ in glucose and energy metabolism. In this review we provide a comprehensive overview of the structure, expression pattern and regulation of apelin and its receptor, as well as the main second messengers and signalling proteins activated by apelin. We also highlight the physiological and pathological roles that support this system as a novel therapeutic target for pharmacological intervention in treating conditions related to altered water balance, stress-induced disorders such as anxiety and depression, and cardiovascular and metabolic disorders.

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Section: Other Functions Of the Apelinergic Systemmentioning

confidence: 99%

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

O’Carroll

Lolait

Harris

et al. 2013

Journal of Endocrinology

292

216

View full text Add to dashboard Cite

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“…Wang et al showed that apelin stimulates the gastric cell proliferation and also stimulates CCK secretion by mitogen-activated protein kinase (10). Another study demostrated that intravenous apelin administrations stimulate and elevate gastric acid secretion in rats (18). The studies show that apelin interacts with orexigenic and/ or anorexigenic factors of the gastrointestinal tract considering energy metabolism and feeding regulation.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Flemström et al showed that intra-arterial apelin-13 infusion stimulates bicarbonate secretion in duodenum (17). In addition, apelin-12 elevates gastric acid secretion by stimulating histamine release in gastric mucosa in rats (18).…”

Section: Introductionmentioning

confidence: 92%

Apelin-13 increased food intake with serum ghrelin and leptin levels in male rats

Saral¹,

Alkanat²,

Sümer³

et al. 2018

BLL

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In this study, we aimed to explain the role of apelin-13 on body weight, food and water intake with serum leptin, ghrelin, neuropeptid Y (NPY) and peptid YY (PYY) levels in male rat. Thirty-two Sprague-Dawley male rats were used for the study. The rats were injected SP (0.9 %) intraperitoneally (i.p) in the control group and 30 (AP30), 100 (AP100) and 300 (AP300) μg/kg apelin-13 in the study groups, respectively, 10 min before the transition to dark period, for 10 days. During the experimental period, with light and dark periods of food and water intake, body weights were recorded in rats. Rats were euthanized and serum samples were obtained. In serum samples leptin, ghrelin, NPY and PYY levels were measured with specifi c ELISA kit. Apelin-13 was increased body weights in all three (AP30, AP100 and AP300) groups compared with the control group. AP100 and AP300 groups had increased food intake in the dark and the cumulative period, but in the light period food intake values were not signifi cantly increased (p > 0.05). As for the value of water intake, compared with the control group, all dose of apelin-13 increased water intake during the dark and the cumulative period. There was no signifi cant change in water intake in the light period. On the other hand, compared with the control group, serum leptin levels were found to increase in the groups administered 100 and 300 μg/kg of apelin-13 (p < 0.05). Ghrelin levels were found high in all groups treated with apelin-13. Serum levels of NPY decreased only in the 300 μg/kg apelin-13 treated group (p < 0.05). There was no statistically signifi cant change in levels of PYY (p > 0.05). Apelin-13 increases body weight in rats as well as food and water intake (dark and cumulative period). Additionally, ghrelin can mediate the orexigenic effect of apelin-13 in the regulation of food intake (Fig. 4, Ref. 37). Text in PDF www.elis.sk.

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“…Apelin, a peptide isolated from stomach, stimulates acid secretion in lumen-perfused rats [28]. The effect was accompanied by an increase in histamine secretion and blocked by famotidine, implying that it was mediated by release of histamine from ECL cells.…”

Section: Apelinmentioning

confidence: 99%

Gastric secretion

Chu

Schubert

2012

Current Opinion in Gastroenterology

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Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs

Cited by 22 publications

References 22 publications

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

Apelin-13 increased food intake with serum ghrelin and leptin levels in male rats

Gastric secretion

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