Apigenin: A Promising Molecule for Cancer Prevention

Shukla, Sanjeev; Gupta, Sanjay

doi:10.1007/s11095-010-0089-7

Cited by 685 publications

(469 citation statements)

References 135 publications

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“…However, a number of other candidates emerged from the screen that warranted further investigation. Among these candidates was apigenin (4′,5,7,-trihydroxyflavone; MW, 270.24), a naturally occurring flavonoid present in several plants and having little or no toxicity when obtained from the diet (Ross andKasum 2002, Shukla andGupta 2010).…”

Section: Introductionmentioning

confidence: 99%

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells

et al. 2017

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Apigenin (4′,5,7,-trihydroxyflavone) is a flavonoid found in certain herbs, fruits, and vegetables. Apigenin can attenuate inflammation, which is associated with many chronic diseases of aging. Senescent cellsstressed cells that accumulate with age in mammalsdisplay a pro-inflammatory senescence-associated secretory phenotype (SASP) that can drive or exacerbate several age-related pathologies, including cancer. Flavonoids, including apigenin, were recently shown to reduce the SASP of a human fibroblast strain induced to senesce by bleomycin. Here, we confirm that apigenin suppresses the SASP in three human fibroblast strains induced to senesce by ionizing radiation, constitutive MAPK (mitogen-activated protein kinase) signaling, oncogenic RAS, or replicative exhaustion. Apigenin suppressed the SASP in part by suppressing IL-1α signaling through IRAK1 and IRAK4, p38-MAPK, and NF-κB. Apigenin was particularly potent at suppressing the expression and secretion of CXCL10 (IP10), a newly identified SASP factor. Further, apigenin-mediated suppression of the SASP substantially reduced the aggressive phenotype of human breast cancer cells, as determined by cell proliferation, extracellular matrix invasion, and epithelialmesenchymal transition. Our results support the idea that apigenin is a promising natural product for reducing the impact of senescent cells on age-related diseases such as cancer.

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Section: Introductionmentioning

confidence: 99%

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells

et al. 2017

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“…Flavonoids are a group of polyphenols that share similar chemical features and are abundant in vegetables, fruits and tea, amongst other products (2). Humans absorb a large amount of flavonoids orally, and epidemiological studies have revealed that the risk of certain types of cancer, particularly cancers of the breast, digestive tract, skin, prostate and certain hematological malignancies, is inversely correlated with intake of flavonoids (3,4). Flavonoids possess antioxidative, anti-inflammatory and antitumor properties (5).…”

Section: Introductionmentioning

confidence: 99%

“…Apigenin (4' ,5,7-trihydroxyflavone) is a promising chemopreventive agent that is abundantly present in fruits, vegetables, and teas (3). This compound has anticarcinogenic properties via diverse mechanisms and is suggested to have a tumor preventative effect (3,9).…”

Section: Introductionmentioning

confidence: 99%

Apigenin enhances the cisplatin cytotoxic effect through p53-modulated apoptosis

Liu

et al. 2016

Oncology Letters

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Abstract. Epidemiological and experimental evidence suggests that dietary flavonoids, including apigenin, have anticancer roles. Apigenin has been reported to elevate p53, a critical molecule in the induction of apoptosis. The present study aimed to investigate whether apigenin, a dietary flavonoid, improves the cytotoxic effect of cisplatin in a cancer cell culture system, and to elucidate the mechanism of this effect. Multiple tumor cell types were treated with apigenin, cisplatin or both drugs. Cell viability was evaluated, and the cytotoxic effect was determined biochemically and microscopically. Treatment with apigenin increased cisplatin-induced DNA damage and the apoptosis of tumor cells in a p53-dependent manner. Apigenin, when used with cisplatin, inhibited cell proliferation and promoted mitogen-activated protein kinase activation and subsequent p53 phosphorylation, leading to p53 accumulation and upregulation of proapoptotic proteins. Cisplatin is one of the most commonly used chemotherapeutic drugs for malignant tumors, but resistance to this drug occurs. The current results therefore demonstrate that dietary flavonoids may diminish the resistance of cancers to cisplatin.

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“…For example, 2015 research found apigenin to inhibit the growth of breast cancer cells, including HER2-positive ones [24]. 2006 research published in Molecular Cancer found that apigenin inhibits growth of pancreatic cancer cells through suppression of cyclin B-associated cdc2 activity and G2/M cell cycle arrest [25].…”

Section: Parsleymentioning

confidence: 99%

Potential Therapeutic Effects of Phytochemicals and Medicinal Herbs for Cancer Prevention and Treatment

Jacobs¹

2018

Arch Gen Intern Med

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Cancer has a major impact on society across the world. It is one of the major causes of death, with approximately 1.7 million new cases expected to be diagnosed in the United States and 600,000 people will die from the disease. Worldwide statistics in 2012 reported over 14 million new cases and 8.2 million cancer-related deaths. New cases are expected to rise by about 70% over the next 20 years. The current standard of care, surgery, chemotherapy, and radiation has not proved to be highly effective and comes with significant side effects and costs. Although conventional cancer therapy can target certain cancer cells and sometimes prevent relapse of the illness, complementary and alternative therapies are required due to disadvantages of the current therapies such as low effectiveness, adverse effects, or availability. Moreover, a number of studies have found adjunctive therapeutic approaches to improve outcomes for cancer patients. One potential complementary method with conventional cancer drugs involves the use of medicinal herbs and phytochemicals. The possible therapeutic benefits include, but are not limited to antiproliferative, apoptotic, anti-metastatic, and anti-angiogenic effects, of which have been demonstrated in in vitro experiments and some clinical trials; more clinical trials need to be done. This review summarizes some plant sources exhibiting anti-cancer and chemoprevention activity. An overview of how phytochemicals and medicinal herbs permit the prevention and ultimate removal of cancer cells with minimal trauma to the host will be presented.

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Apigenin: A Promising Molecule for Cancer Prevention

Cited by 685 publications

References 135 publications

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells

Apigenin enhances the cisplatin cytotoxic effect through p53-modulated apoptosis

Potential Therapeutic Effects of Phytochemicals and Medicinal Herbs for Cancer Prevention and Treatment

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