Apigenin Induced Apoptosis by Downregulating Sulfiredoxin Expression in Cutaneous Squamous Cell Carcinoma

Wang, Wenhua; Liu, Xin; Zhang, Zhibao; Yin, Mingzhu; Chen, Xiang; Wu, Lisha

doi:10.1155/2022/8172866

Cited by 7 publications

(9 citation statements)

References 37 publications

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“…Apigenin has a noteworthy role in apoptosis induction. It increased apoptosis through the activation of the MAPK signaling pathway, as well as through the reduction in sulfiredoxin expression [ 68 ]. Apigenin was demonstrated to increase poly-(ADP-ribose) polymerase (PARP) proteolytic cleavage and to trigger a rapid enhancement of caspase-3 activity.…”

Section: Molecular Mechanisms Of Apigenin and Isovitexin Involved In ...mentioning

confidence: 99%

Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells

et al. 2023

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It has been demonstrated that cancer stem cells (CSCs) go through metabolic changes that differentiate them from non-CSCs. The altered metabolism of CSCs plays a vital role in tumor initiation, progression, immunosuppression, and resistance to conventional therapy. Therefore, defining the role of CSC metabolism in carcinogenesis has emerged as a main focus in cancer research. Two natural flavonoids, apigenin and isovitexin, have been shown to act synergistically with conventional chemotherapeutic drugs by sensitizing CSCs, ultimately leading to improved therapeutic efficacy. The aim of this study is to present a critical and broad evaluation of the anti-CSC capability of apigenin and isovitexin in different cancers as novel and untapped natural compounds for developing drugs. A thorough review of the included literature supports a strong association between anti-CSC activity and treatment with apigenin or isovitexin. Additionally, it has been shown that apigenin or isovitexin affected CSC metabolism and reduced CSCs through various mechanisms, including the suppression of the Wnt/β-catenin signaling pathway, the inhibition of nuclear factor-κB protein expression, and the downregulation of the cell cycle via upregulation of p21 and cyclin-dependent kinases. The findings of this study demonstrate that apigenin and isovitexin are potent candidates for treating cancer due to their antagonistic effects on CSC metabolism.

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Section: Molecular Mechanisms Of Apigenin and Isovitexin Involved In ...mentioning

confidence: 99%

Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells

et al. 2023

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“…Another target of apigenin in SCC is Sulfiredoxin (Srx), a protein with an oncogenic role in skin tumorigenesis. A study by Wang et al showed that apigenin induces apoptosis by downregulating Srx through the MAPK pathway in SCC cells [ 86 ]. Regarding the regulation of oxidative stress, Paredes-Gonzalez et al found that apigenin can reverse the hypermethylation of 15 CpG sites in the Nrf2 promoter in skin epidermal JB6 P+ cells.…”

Section: Discussionmentioning

confidence: 99%

“…Zhang et al observed that the use of resveratrol as an adjuvant for PDT potentiates the effect of tumor growth inhibition in cells with SCC; the pathway involved would appear to be that of p38/MAPK [ 86 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Nutraceuticals and Functional Foods in Skin Cancer: Mechanisms and Therapeutic Potential

Peterle

Sanfilippo

Borgia

et al. 2023

Foods

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Skin cancer is a prevalent type of cancer worldwide and has a high growth rate compared to other diseases. Although modern targeted therapies have improved the management of cutaneous neoplasms, there is an urgent requirement for a safer, more affordable, and effective chemoprevention and treatment strategy for skin cancer. Nutraceuticals, which are natural substances derived from food, have emerged as a potential alternative or adjunctive treatment option. In this review, we explore the current evidence on the use of omega-3 fatty acids and polyphenols (curcumin, epigallocatechin gallate, apigenin, resveratrol, and genistein) for the treatment of melanoma and non-melanoma skin cancer (NMSC), as well as in their prevention. We discuss the mechanisms of action of the aforementioned nutraceuticals and their probable therapeutic benefits in skin cancer. Omega-3 fatty acids, curcumin, epigallocatechin gallate, apigenin, resveratrol, and genistein have several properties, among which are anti-inflammatory and anti-tumor, which can help to prevent and treat skin cancer. However, their effectiveness is limited due to poor bioavailability. Nanoparticles and other delivery systems can improve their absorption and targeting. More research is needed to evaluate their safety and effectiveness as a natural approach to skin cancer prevention and treatment. These compounds should not replace conventional cancer treatments, but may be used as complementary therapy under the guidance of a healthcare professional.

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“…Apigenin has been shown to have a significant part in causing apoptosis. This is accomplished by triggering the MAPK signaling pathway and reducing sulfiredoxin expression (Wang et al, 2022 ). Studies have demonstrated that apigenin increases the cleavage of poly‐(ADP‐ribose) polymerase (PARP) and rapidly enhances caspase‐3 activity, resulting in DNA fragmentation and apoptosis (Ghanbari‐Movahed et al, 2023 ; Gupta et al, 2002 ).…”

Section: Overview Of Apigeninmentioning

confidence: 99%

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

Daneshvar,

Zamanian,

Ivraghi

et al. 2023

Food Science & Nutrition

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Colon cancer (CC) is one of the most common and deadly cancers worldwide. Oncologists are facing challenges such as development of drug resistance and lack of suitable drug options for CC treatment. Flavonoids are a group of natural compounds found in fruits, vegetables, and other plant‐based foods. According to research, they have a potential role in the prevention and treatment of cancer. Apigenin is a flavonoid that is present in many fruits and vegetables. It has been used as a natural antioxidant for a long time and has been considered due to its anticancer effects and low toxicity. The results of this review study show that apigenin has potential anticancer effects on CC cells through various mechanisms. In this comprehensive review, we present the cellular targets and signaling pathways of apigenin indicated to date in in vivo and in vitro CC models. Among the most important modulated pathways, Wnt/β‐catenin, PI3K/AKT/mTOR, MAPK/ERK, JNK, STAT3, Bcl‐xL and Mcl‐1, PKM2, and NF‐kB have been described. Furthermore, apigenin suppresses the cell cycle in G2/M phase in CC cells. In CC cells, apigenin‐induced apoptosis is increased by inhibiting the formation of autophagy. According to the results of this study, apigenin appears to have the potential to be a promising agent for CC therapy, but more research is required in the field of pharmacology and pharmacokinetics to establish the apigenin effects and its dosage for clinical studies.

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Apigenin Induced Apoptosis by Downregulating Sulfiredoxin Expression in Cutaneous Squamous Cell Carcinoma

Cited by 7 publications

References 37 publications

Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells

Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells

The Role of Nutraceuticals and Functional Foods in Skin Cancer: Mechanisms and Therapeutic Potential

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

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