Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives

Salmani, Jumah Masoud Mohammad; Zhang, Xiaoping; Jacob, Joe Antony; Chen, Baoan

doi:10.1016/s1875-5364(17)30052-3

Cited by 60 publications

(44 citation statements)

References 44 publications

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“…The most sensible were treated leukemia cells K562, whose growth was significantly reduced (up to 80%) after 48 h of exposure. Observed results correlate with published data based on the cytotoxic effect of apigenin on leukemia cells 33,34 described significant influence of apigenin on the growth of myeloid (HL-60 and K562) com- pared to the erythroid (TF1) leukemia cells. Lower tested concentrations (0.01, 0.001 and 0.0001 mg/mL) only slightly affected the growth of treated cells (data not shown).…”

Section: The Antiproliferative Activity Of the Clf Extractssupporting

confidence: 89%

Autofermentation of Chamomile Ligulate Flowers Promote Antitumor Effects in vitro

Jukić

Cvetanović

Špoljarić

et al. 2019

ACSi

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In the frame of this paper, the enzyme-assisted hydrolysis coupled with ultrasound and Soxhlet extraction was applied in order to get extracts of chamomile ligulate flowers (CLF). Obtained extracts were characterized in terms to their apigenin and apigenin glucoside composition, as well as antiproliferative potential against tumour cells. Antioxidant activity was determined by two different assays based on different mechanisms showing that autofermented extracts have higher reduction potential. Autofermented extracts prepared by ultrasound and Soxhlet extraction had a stronger impact on the treated carcinoma (HeLa and NCI-H358) and leukemia (K562) cells' growth reduction in comparison to the native extracts, 30-35% greater inhibition at the lowest concentration (0.01 mg/mL), in two observed time points (48 and 72 h). Leukemia cells are more sensitive to all tested extracts. The autofermented CLF extracts with highest antiproliferative efficacy induced morphological changes and apoptosis in the HeLa cells. Obtained results clearly showed that the combination of enzymatic hydrolysis with cavitation phenomenon results in extracts with higher apigenin content and increased biological potential.

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Section: The Antiproliferative Activity Of the Clf Extractssupporting

confidence: 89%

Autofermentation of Chamomile Ligulate Flowers Promote Antitumor Effects in vitro

Jukić

Cvetanović

Špoljarić

et al. 2019

ACSi

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“…Furthermore, kaempferol exerted cytotoxic effects on rat hepatocellular carcinoma cells via ROS-mediated mitochondrial targeting [81]. The anticancer activities of flavones apigenin and luteolin in ovarian cancer cell lines (A2780, OVCAR-3 and SKOV-3) were also related to the changes in ROS signaling, as well as to the promotion of apoptosis [82,83]. Moreover, apigenin activated apoptosis also in human cervical cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16 and HPV 18-positive), and C33A (HPV-negative) cells due to increased ROS generation and launched mitochondrial apoptotic pathways [84].…”

Section: Flavonoids In Oxidative Stressmentioning

confidence: 99%

Flavonoids as Anticancer Agents

et al. 2020

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Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis—they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. This article reviews the biochemical properties and bioavailability of flavonoids, their anticancer activity and its mechanisms of action.

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“…Antioxidant properties of rutin were reported by Yang (Yang, Guo, & Yuan, ). In addition, anticancer effect of some compounds was demonstrated from earlier works: apigenin (Bao, Zhou, Fan, & Wang, ; Salmani, Zhang, Jacob, & Chen, ) and ferulic acid (Kumar et al, ). The results of compound analysis helped to confirm that the EH had higher levels of antioxidant capacities compared to MH, which could be because the structure activity of antioxidative property of the phenolic compounds in the EH is stronger than that in the MH.…”

Section: Resultsmentioning

confidence: 91%

Antioxidant activities and HepG2 cells growth inhibitory capacity of whole plant ethanol extracts (Eclipta alba Hassk and Mesona procumbens Hemsl)

Lay

2017

J Food Biochem

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This study investigated in vitro antioxidant and hepatocellular carcinoma (HepG2) cells growth inhibitory effect of Eclipta alba Hassk (EH) and Mesona procumbens Hemsl (MH). Extracts from ethanol 50% (E50) were chosen for the assays. Total phenolic and flavonoid content and the antioxidant activities including ABTS 1 and DPPH radical-scavenging system were determined. The identification of phenolic compounds was analyzed by high performance liquid chromatography (HPLC). It was found that higher levels of DPPH and ABTS 1 radical-scavenging activity were detected from the EH extract with IC 50 of 41.91 6 0.08 and 75.49 6 1.15 mg/mL, respectively. The rate of DPPH radical-scavenging activity was significantly influenced by the reaction time. The 4hydroxybenzoic acid, caffeic acid, p-coumaric acid, and rosmarinic acid were the identified compounds in the EH. The 7-hydroxycoumarin, ferulic acid, and rutin being new compounds and two known compounds were identified in the MH. Lactate dehydrogenase released in medium was also evaluated. Extracts of the EH and MH stimulated the apoptotic factors bcl-2, bax, caspase-3, caspase-9 in HepG2. Overall, the EH extract was higher in total phenolic and flavonoid content, antioxidant potential and more effective in inhibiting cancer cell growth.

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Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives

Cited by 60 publications

References 44 publications

Autofermentation of Chamomile Ligulate Flowers Promote Antitumor Effects in vitro

Autofermentation of Chamomile Ligulate Flowers Promote Antitumor Effects in vitro

Flavonoids as Anticancer Agents

Antioxidant activities and HepG2 cells growth inhibitory capacity of whole plant ethanol extracts (Eclipta alba Hassk and Mesona procumbens Hemsl)

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