Aplastic Crisis Caused by Human Parvovirus in Two Patients WJTH Hereditary Stomatocytosis

Mabin, D; Chowdhury, Vijay

doi:10.1111/j.1365-2141.1990.tb07855.x

Cited by 17 publications

(7 citation statements)

References 6 publications

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“…Case 2. This case has already been reported in this journal (Mabin & Chowdhury, 1990), but bears repeating. In essence, a child with hereditary stomatocytosis (the daughter of the patient V first described in 1962: Lock et al , 1962) was admitted with a haemoglobin of 2·7 g/dl, and was both pyrexial and jaundiced.…”

supporting

confidence: 81%

Hereditary haemolytic anaemias and parvovirus infections in jehovah's witnesses

Barton¹,

Chowdhury

Mabin³

2003

Br J Haematol

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supporting

confidence: 81%

Hereditary haemolytic anaemias and parvovirus infections in jehovah's witnesses

Barton¹,

Chowdhury

Mabin³

2003

Br J Haematol

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“…Her second pregnancy was uneventful. This patient later died from a parvovirus infection (Mabin & Chowdhury, 1990). She had an affected son and daughter.…”

Section: Case Reportsmentioning

confidence: 94%

Thrombo‐embolic Disease After Splenectomy for Hereditary Stomatocytosis

et al. 1996

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Nine cases of hereditary stomatocytosis (HSt) are presented which show documented thrombotic complications after splenectomy. In three cases, patients became severely ill with pulmonary hypertension and a fourth developed portal hypertension. One unsplenectomized affected adult relative had suspected but unconfirmed thrombotic pathology; the six other affected unsplenectomized adults did not. Since splenectomy is of only limited therapeutic benefit in stomatocytosis, it should not be performed without careful consideration. A tendency to iron overload, even without hypertransfusion and irrespective of splenectomy, is evident in many of these patients.

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“…Although the erythrocytes are predominantly affected, with presentation often of a pure red cell aplasia, concurrent thrombocytopenia, neutropenia, or pancytopenia is found infrequently (179,187,210,264,279). While the anemia may be lethal, the aplastic crisis itself is usually terminated by the appearance of specific antibodies and thus rarely lasts for more than 2 weeks.…”

Section: Infection In Patients With Increased Red Cell Turnovermentioning

confidence: 99%

Human Parvovirus B19

2002

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Parvovirus B19 (B19) was discovered in 1974 and is the only member of the family Parvoviridae known to be pathogenic in humans. Despite the inability to propagate the virus in cell cultures, much has been learned about the pathophysiology of this virus, including the identification of the cellular receptor (P antigen), and the control of the virus by the immune system. B19 is widespread, and manifestations of infection vary with the immunologic and hematologic status of the host. In healthy immunocompetent individuals B19 is the cause of erythema infectiosum and, particularly in adults, acute symmetric polyarthropathy. Due to the tropism of B19 to erythroid progenitor cells, infection in individuals with an underlying hemolytic disorder causes transient aplastic crisis. In the immunocompromised host persistent B19 infection is manifested as pure red cell aplasia and chronic anemia. Likewise, the immature immune response of the fetus may render it susceptible to infection, leading to fetal death in utero, hydrops fetalis, or development of congenital anemia. B19 has also been suggested as the causative agent in a variety of clinical syndromes, but given the common nature, causality is often difficult to infer. Diagnosis is primarily based on detection of specific antibodies by enzyme-linked immunosorbent assay or detection of viral DNA by dot blot hybridization or PCR. Treatment of persistent infection with immunoglobulin reduces the viral load and results in a marked resolution of anemia. Vaccine phase I trials show promising results

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Aplastic Crisis Caused by Human Parvovirus in Two Patients WJTH Hereditary Stomatocytosis

Cited by 17 publications

References 6 publications

Hereditary haemolytic anaemias and parvovirus infections in jehovah's witnesses

Hereditary haemolytic anaemias and parvovirus infections in jehovah's witnesses

Thrombo‐embolic Disease After Splenectomy for Hereditary Stomatocytosis

Human Parvovirus B19

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